가역적인 전두엽 기능 이상을 보인 교뇌외 수초융해증
Reversible Frontal Lobe Dysfunction in a Patient with Extrapontine Myelinolysis
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Extrapontine myelinolysis (EPM) is an acute demyelinating disease caused by rapidly fluctuating serum osmolality. EPM mainly affects the bilateral basal ganglia, such as the caudate nucleus, putamen, and globus pallidus. Its major clinical symptoms are movement disorders such as parkinsonism, dystonia, and catatonia. However, frontal lobe dysfunction, such as executive dysfunction, personality changes, and apathy, is rare. We report a patient with EPM with reversible frontal lobe dysfunction without any definite movement symptoms. EPM should be included in the differential diagnosis when a patient shows acute behavioral changes following correction of electrolyte imbalance.
Abstract
Extrapontine myelinolysis (EPM) is an acute demyelinating disease caused by rapidly fluctuating serum osmolality. EPM mainly affects the bilateral basal ganglia, such as the caudate nucleus, putamen, and globus pallidus. Its major clinical symptoms are movement disorders such as parkinsonism, dystonia, and catatonia. However, frontal lobe dysfunction, such as executive dysfunction, personality changes, and apathy, is rare. We report a patient with EPM with reversible frontal lobe dysfunction without any definite movement symptoms. EPM should be included in the differential diagnosis when a patient shows acute behavioral changes following correction of electrolyte imbalance.