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Central Pontine Myelinolysis Presenting With Cerebellar Ataxia

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초록

Central pontine myelinolysis (CPM) is a neurologic disorder that is usually related to rapid correction of hyponatremia and chronic alcoholism. CPM involves concentrated, symmetric, noninflammatory demyelination within the central pons; this pathology also occurs in extrapontine regions. Frequently observed clinical manifestations are sudden weakness, dysphagia, dysarthria, loss of consciousness, and locked-in syndrome. We describe herein a case of CPM predominated by cerebellar signs without typical symptoms, but with involvement of the cerebellum or cerebellar peduncle.

Abstract

Central pontine myelinolysis (CPM) is a neurologic disorder that is usually related to rapid correction of hyponatremia and chronic alcoholism. CPM involves concentrated, symmetric, noninflammatory demyelination within the central pons; this pathology also occurs in extrapontine regions. Frequently observed clinical manifestations are sudden weakness, dysphagia, dysarthria, loss of consciousness, and locked-in syndrome. We describe herein a case of CPM predominated by cerebellar signs without typical symptoms, but with involvement of the cerebellum or cerebellar peduncle.

참고문헌 (8)

  1. Adams RD, "Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients", AMA Arch Neurol Psychiatry, 81, pp.154~172 (1959)
  2. Wright DG, "Pontine and extra-pontine myelinolysis", Brain, 102, pp.361~385 (1979)
  3. Maraganore DM, "Movement disorders as sequelae of central pontine myelinolysis: report of three cases", Mov Disord, 7, pp.142~148 (1992)
  4. Garzon T, "Ataxic form of central pontine myelinolysis", Lancet Neurol, 1, pp.517~518 (2002)
  5. Rajbhandari SM, "Ward JD. Central pontine myelinolysis and ataxia: an unnusual manifestation of hypoglycemia", Diabet Med, 15, pp.259~261 (1998)
  6. Pfister HW, "Mild central pontine myelinolysis:a frequently undetected syndrome", Eur Arch Psychiatry Neurol Sci, 235, pp.134~139 (1985)
  7. Somarajan A, "Ataxic form of central pontine myelinolysis", Ann Indian Acad Neurol, 10, pp.112~114 (2007)
  8. Ozgur-Ilhan I, "Alcoholic case of central pontine myelinolysis with mainly cerebellar signs", Eur Addict Res, 11, pp.155~156 (2005)

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