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담즙정체가 동반된 환자에서 혈중 고밀도지질단백질 콜레스테롤 농도의 검사방법에 따라 차이를 보이는 증례에 대한 고찰

Cholestasis Causes Discrepancy in HDL-Cholesterol Levels Measured Using Various Methods

김기수|민원기|이우창|전사일|김솔잎
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2012.07|Laboratory Medicine Online|제2권 제3호|pp. 174-178|DOI http://dx.doi.org/

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참고문헌

키워드

DiscrepancyCholestasisHDL-Cholesterol

초록

저자들은 쓸개즙 정체 환자에서 HDL 균질법 검사시약에 따라고밀도지질단백질 결과가 달랐던 증례를 보고하는 바이다. 이러한 결과 차이는 환자의 혈청에 비정상 지질단백질, 즉 apo E-rich HDL이 증가하였기 때문이었다. 지질단백질 전기이동에서는 느린α이동 띠가 관찰되었고, 저밀도지질단백질 소분획 검사에서는 입자의 크기가 큰 HDL이 관찰되었다. 혈청 아포지질단백질 E 농도는증가되어 있었다.

Abstract

Herein, we report a case in which cholestasis caused discrepancy in high-density lipoprotein (HDL)-cholesterol levels measured using various methods. The discrepancy in HDL-cholesterol level originated from the abnormal increase in the level of an unusual lipoprotein, apo E-rich HDL, in the patient’s serum. An abnormal slow alpha-migrating lipoprotein was observed on agarose gel electrophoresis, and an abnormal large-sized HDL was observed in a lipoprotein subfraction study. The level of apolipoprotein E was elevated.

참고문헌 (15)

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