Olanzapine으로 인한 과혈당 발생 연구

Abstract

Olanzapine is an effective atypical antipsychotic agent and has smaller adverse effects than typical antipsychotics. Since Olanzapine was used, it's been reported hyperglycemia and diabetic ketone acidosis induced by it. Hyperglycemia which increases morbidity and mortality of patients isn't easily recognized. Therefore this study was carried out to investigate the aspect of hyperglycemia induced by Olanzapine. We selected patients who were administered Olanzapine in Seoul National University Hospital from September 2002 to August 2004. We excluded patients who were taken other antipsychotic agents and have diabetes mellitus and no Blood Sugar Level(BSL). And patients whose duration of Olanzapine administration was below 8 weeks were also excluded. The number of selected patients was 77. The mean age of selected patients was 35.8(± 13.5) years old and mean dosage and mean duration were 10.2(± 6.2) mg/day, 533.2(± 259.1) days. Subjective patients were consisted of 44 male and 33 female. We found 26 patients whose fasting BSL was over 110 mg/dl. The mean age of them was 43.7(± 15.05) years old and each number of male and female was 15, 11 respectively. The incidence of elevation of blood glucose level was 33.8%. The mean age of elevated BSL group was more higher than that of normal group(P=0.02). When the age of patients was divided 8 grades, the relationship of age and BSL elevation percentage was evaluated linear. We found no significant relativity between BSL elevation and mean age, sex.