악성흉선종 수술 후 아세틸콜린수용체 항체와 연관되어 발생한 Issac증후군
Isaacs’ Syndrome Associated With Acetylcholine Receptor Antibodies Developed After Removal of Malignant Thymoma
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Isaacs’ syndrome is a rare and heterogeneous syndrome of continuous muscle fiber activity that originates from peripheral nerves. We report a 56-year-old male patient who showed symptoms of Isaacs’ syndrome after the removal a malignant thymoma. Needle electromyography revealed spontaneously occurring repetitive myokymic discharge the affected muscles. Acetylcholine receptor (AChR) antibodies were significantly elevated, but clinical and electrophysiologic findings did not indicate the presence of myasthenia gravis. We deduce that in Isaacs’ syndrome,raised AChR antibodies may facilitate rather than inhibit cholinergic action.
Abstract
Isaacs’ syndrome is a rare and heterogeneous syndrome of continuous muscle fiber activity that originates from peripheral nerves. We report a 56-year-old male patient who showed symptoms of Isaacs’ syndrome after the removal a malignant thymoma. Needle electromyography revealed spontaneously occurring repetitive myokymic discharge the affected muscles. Acetylcholine receptor (AChR) antibodies were significantly elevated, but clinical and electrophysiologic findings did not indicate the presence of myasthenia gravis. We deduce that in Isaacs’ syndrome,raised AChR antibodies may facilitate rather than inhibit cholinergic action.
참고문헌 (10)
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