Myasthenia in Acquired Neuromyotonia
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Background Acquired neuromyotonia (NMT) forms part of the spectrum of acquired peripheral nerve hyperexcitability syndrome, and is thought to be caused by antibodies to voltage-gated potassium channels (VGKC). Exertional weakness is unusual unless autoimmune myastheniagravis (MG) is superimposed. Case Report A case of acquired NMT accompanied by exertional weakness without coexistence of seropositive MG is reported herein. Conclusions Clinical and electrophysiological observations suggest that the cholinergic overactivity in NMT can compromise the safety factor sufficiently to cause a defect in neuromuscular junction transmission.
Abstract
Background Acquired neuromyotonia (NMT) forms part of the spectrum of acquired peripheral nerve hyperexcitability syndrome, and is thought to be caused by antibodies to voltage-gated potassium channels (VGKC). Exertional weakness is unusual unless autoimmune myastheniagravis (MG) is superimposed. Case Report A case of acquired NMT accompanied by exertional weakness without coexistence of seropositive MG is reported herein. Conclusions Clinical and electrophysiological observations suggest that the cholinergic overactivity in NMT can compromise the safety factor sufficiently to cause a defect in neuromuscular junction transmission.
참고문헌 (7)
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