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Seropositive Myasthenia Gravis Associated with Small-Cell Lung Carcinoma

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Background:Lambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic syndrome of small cell lung carcinoma (SCLC). Three cases of seronegative myasthenia gravis (MG) and SCLC were previously reported. Case Report:A 65-year-old man developed a severe progressive respiratory failure with clinical features of MG. Tests showed a decremental response in the repetitive nerve stimulation test,abnormal single-fiber electromyography, and positive acetylcholine receptor antibody. SCLC was confirmed by the lung biopsy. Conclusions:This case represents the first case of seropositive MG and SCLC.

Abstract

Background:Lambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic syndrome of small cell lung carcinoma (SCLC). Three cases of seronegative myasthenia gravis (MG) and SCLC were previously reported. Case Report:A 65-year-old man developed a severe progressive respiratory failure with clinical features of MG. Tests showed a decremental response in the repetitive nerve stimulation test,abnormal single-fiber electromyography, and positive acetylcholine receptor antibody. SCLC was confirmed by the lung biopsy. Conclusions:This case represents the first case of seropositive MG and SCLC.

참고문헌 (8)

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  8. Lennon VA, "Serologic profile of myasthenia gravis and distinction from the Lambert-Eaton syndrome", Neurology, 48, pp.23~27 (1997)

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