Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in Korea: three case reports
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초록
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune paraneoplastic syndrome associated with ovarian teratomas. Most patients develop neurologic symptoms, including psychosis, memory deficits, seizures, or abnormal movements, and experience abdominal pain related to ovarian neoplasm. We present a case report of three patients diagnosed with anti-NMDAR encephalitis accompanied by ovarian teratomas at Ajou University Hospital in Korea. The patients demonstrated a different clinical course of the disease. However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. The symptoms progressively improved following treatment. This is a case report of a rare autoimmune anti-NMDAR encephalitis associated with ovarian neoplasms, including immature teratoma.
Abstract
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune paraneoplastic syndrome associated with ovarian teratomas. Most patients develop neurologic symptoms, including psychosis, memory deficits, seizures, or abnormal movements, and experience abdominal pain related to ovarian neoplasm. We present a case report of three patients diagnosed with anti-NMDAR encephalitis accompanied by ovarian teratomas at Ajou University Hospital in Korea. The patients demonstrated a different clinical course of the disease. However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. The symptoms progressively improved following treatment. This is a case report of a rare autoimmune anti-NMDAR encephalitis associated with ovarian neoplasms, including immature teratoma.
참고문헌 (13)
- Braverman JA, "Anti-NMDA-receptor encephalitis : a neuropsychiatric syndrome associated with ovarian teratoma", Gynecol Oncol Rep, 14, pp.1~3 (2015)
- Dalmau J, "Clinical experience and laboratory investiga-tions in patients with anti-NMDAR encephalitis", Lancet Neurol, 10, pp.63~74 (2011)
- Irani SR, "N-methyl-D-aspartate antibody encephalitis : temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes", Brain, 133, pp.1655~1667 (2010)
- Dalmau J, "Anti-NMDA-receptor encephalitis : case series and analysis of the effects of antibodies", Lancet Neurol, 7, pp.1091~1098 (2008)
- Dalmau J, "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma", Ann Neurol, 61, pp.25~36 (2007)
- Yang YW, "Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma : report of a case and review of literatures", J Neurooncol, 80, pp.309~312 (2006)
- Kemp JA, "NMDA receptor pathways as drug targets", Nat Neurosci, 5(Suppl), pp.1039~1042 (2002)
- Vitaliani R, "Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma", Ann Neurol, 58, pp.594~604 (2005)
- Florance NR, "Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis in children and adolescents", Ann Neurol, 66, pp.11~18 (2009)
- Zakhour M, "Anti-NMDA receptor encephalitis : consider the ovaries", Gynecol Oncol, 137(Suppl 1), pp.105~ (2015)
- Medepalli K, "Psychosis : call a surgeon? A rare etiology of psychosis requiring resection", SAGE Open Med Case Rep, 4, pp.2050313~ (2016)
- Zhang L, "Anti-N-methyl-D-aspartate receptor encephalitis with accompanying ovarian teratoma in female patients from East China: clinical features, treatment, and prognostic outcomes", Seizure, 75, pp.55~62 (2020)
- Chae Hyeong Lee, "Anti-N-methyl-D-aspartate Receptor Encephalitis: a Rare Complication of Ovarian Teratoma", Journal of Korean Medical Science, 35(24), pp.1~5 (2020), 대한의학회[DOI]