메토트렉세이트 경구복용 후 발생한 가역소뇌백질뇌병증
Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate
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초록
Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy followingintrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to thecerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalanceduring walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and theleukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathyassociated with oral MTX.
Abstract
Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy followingintrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to thecerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalanceduring walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and theleukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathyassociated with oral MTX.
참고문헌 (10)
- Gonzalez-Suarez I, "Leukoencephalopathy due to oral methotrexate", Cerebellum, 13, pp.178~183 (2014)
- Chung PW, "A case of diffuse leukoencephalopathy following low does intravenous methotrexate therapy", J Korean Neurol Assoc, 18, pp.77~79 (2000)
- Wernick R, "Central nervous system toxicity associated with weekly low-dose methotrexate treatment", Arthritis Rheum, 32, pp.770~775 (1989)
- Garcia-Puig M, "Neurotoxicity due to methotrexate in paediatric patients. Description of the clinical symptoms and neuroimaging findings", Rev Neurol, 54, pp.712~718 (2012)
- Glass JP, "Treatment-related leukoencephalopathy. A study of three cases and literature review", Medicine (Baltimore), 65, pp.154~162 (1986)
- Quinn CT, "Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer", J Clin Oncol, 15, pp.2800~2806 (1997)
- Linnebank M, "Association of genetic variants of methionine metabolism with methotrexate-induced cns white matter changes in patients with primary CNS lymphoma", Neuro Oncol, 11, pp.2~8 (2009)
- Baslund B, "Reduced folate carrier polymorphism determines methotrexate uptake by B cells and CD4+ T cells", Rheumatology (Oxford), 47, pp.451~453 (2008)
- Hinchey J, "A reversible posterior leukoencephalopathy syndrome", N Engl J Med, 334, pp.494~500 (1996)
- Koppen H, "Reversible leukoencephalopathy after oral methotrexate", J Rheumatol, 39, pp.1906~1907 (2012)