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자가면역간염에서 동반된 다발근염

Polymyositis Associated with Autoimmune Hepatitis

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초록

A 46-year old woman presented with progressive limb weakness and fatigue. Laboratory tests showed abnormalities consistent with autoimmune hepatitis and she was diagnosed with biopsy-proven inflammatory myopathy. The patient was commenced on immunosuppressive therapy with azathioprine 50 mg and prednisolone 1 mg/kg. At the six-month follow up, her symptoms subsided and aminotransferase and muscle enzymes were normalized. This case presents rare case of concomitant development of polymyositis and autoimmune hepatitis.

Abstract

A 46-year old woman presented with progressive limb weakness and fatigue. Laboratory tests showed abnormalities consistent with autoimmune hepatitis and she was diagnosed with biopsy-proven inflammatory myopathy. The patient was commenced on immunosuppressive therapy with azathioprine 50 mg and prednisolone 1 mg/kg. At the six-month follow up, her symptoms subsided and aminotransferase and muscle enzymes were normalized. This case presents rare case of concomitant development of polymyositis and autoimmune hepatitis.

참고문헌 (10)

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  2. Hennes EM, "Simplified criteria for the diagnosis of autoimmune hepatitis", Hepatology, 48, pp.169~176 (2008)
  3. Pestronk A, "Acquired immune and inflammatory myopathies: pathological classification", Curr Opin Rheumatol, 23, pp.595~604 (2011)
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  5. European Association for the Study of the Liver, "EASL clinical practice guidelines: autoimmune hepatitis", J Hepatol, 63, pp.971~1004 (2015)
  6. Pamfil C, "Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome associated with dermatomyositis, autoimmune thyroiditis and antiphospholipid syndrome", J Gastrointestin Liver Dis, 24, pp.101~104 (2015)
  7. Marie I, "Polymyositis, cranial neuropathy, autoimmune hepatitis, and hepatitis C", Ann Rheum Dis, 59, pp.839~840 (2000)
  8. Stefanidis I, "A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis", Clin Nephrol, 70, pp.245~250 (2008)
  9. Kurihara Y, "Polymyositis associated with autoimmune hepatitis, primary biliary cirrhosis, and autoimmune thrombocytopenic purpura", Mod Rheumatol, 21, pp.325~329 (2011)
  10. Pamfil C, "Systemic sclerosis-polymyositis overlap syndrome associated with autoimmune hepatitis and cerebral vasculitis", J Gastrointestin Liver Dis, 21, pp.317~320 (2012)

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