다발성 근염 환자에서 발생한 스테로이드 근병증 1예
Development of Steroid Myopathy during Polymyositis Treatment
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Polymyositis is diffuse, inflammatory myopathy with proximal-muscle weakness due to lymphocyte infiltration to the muscle layer. The exact cause of the muscle weakness is unclear but may be related with an immunologic mechanism. Using high-dose steroid is the treatment of choice for polymyositis. It is difficult to distinguish steroid-resistant polymyositis from steroid myopathy, however, in the course of high-dose steroid therapy. These authors encountered a steroid myopathy patient during polymyositis treatment with high-dose steroid. A 57-year-old woman was diagnosed with polymyositis and was treated with high-dose steroid. Her condition was initially improved, but in the course of the treatment, her symptom was aggravated without increasing the muscle enzymes. Her muscle weakness was improved by reducing the steroid dosage.
Abstract
Polymyositis is diffuse, inflammatory myopathy with proximal-muscle weakness due to lymphocyte infiltration to the muscle layer. The exact cause of the muscle weakness is unclear but may be related with an immunologic mechanism. Using high-dose steroid is the treatment of choice for polymyositis. It is difficult to distinguish steroid-resistant polymyositis from steroid myopathy, however, in the course of high-dose steroid therapy. These authors encountered a steroid myopathy patient during polymyositis treatment with high-dose steroid. A 57-year-old woman was diagnosed with polymyositis and was treated with high-dose steroid. Her condition was initially improved, but in the course of the treatment, her symptom was aggravated without increasing the muscle enzymes. Her muscle weakness was improved by reducing the steroid dosage.
참고문헌 (10)
- Bohan A, "A computer assisted analysis of 153 patients with polymyositis and dermatomyositis", Medicine, 86, pp.255~286 (1977)
- Henriksson KG, "Polymyositis- treatment and prognosis", Acta Neurol Scand, 65, pp.280~300 (1982)
- Amato AA, "Evaluation and treatment of inflammatory myopathies", J Neurol Neurosurg Psychiatry, 80, pp.1060~1068 (2009)
- Sokoloff MC, "Treatment of corticosteroid-resistant polymyositis with methotrexate", Lancet, 1, pp.14~16 (1971)
- Bunch TW, "Prednisone and azathiprine for polymyositis", Arthritis Rheum, 24, pp.45~48 (1981)
- Cherin P, "Efficacy of intravenous immunoglobulin therapy in chronic refractory polymyositis and dermatomyositis: An open study with 20 adult patients", Am J Med, 91, pp.162~168 (1991)
- Kumar S, "Steroid-induced myopathy following a single oral dose of prednisolone", Neurol India, 51, pp.554~556 (2003)
- Inder WJ, "Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1- implications for steroid- induced myopathy", Clin Endocrinol, 73, pp.126~132 (2010)
- Betters JL, "Nitric oxide reverses prednisolone-induced inactivation of muscle satellite cells", Muscle Nerve, 37, pp.203~209 (2008)
- Dekhuijzen PN, "Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered", Eur Respir J, 5, pp.997~1003 (1992)