CSP0510 Lotion as a Novel Moisturizer Containing Citric Acid and Trisodium Phosphate Relieves Objective and Subjective Symptoms of Atopic Dermatitis
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Moisturizers with anti-inflammatory or anti- itch activity should be developed for the safe and effective management of atopic dermatitis (AD). Objective: This study evaluated the efficacy of a newly developed moisturizer, CSP0510 lotion (Twolines Inc., Korea), containing citric acid (CA) and trisodium phosphate (TSP) as active ingredients, in mild to moderate AD. Methods and Results: CSP0510 lotion applied twice daily for 4 weeks to eczematous lesions improved objective and subjective (itch) symptoms of AD. The physician’s global assessment (PGA) score for objective symptoms decreased from 2.5±0.6 before application to 1.3±0.5 after application in the CSP0510-treated group (n=42, p＜0.001). Also, the PGA score decreased from 2.3±0.6 to 1.9±0.5 by vehicle-treated (without CA and TSP) control group (p=0.001), but there was no statistical difference between CSP0510-treated and vehicle-treated groups (p=0.089). The visual analogue scale score for itch decreased from 4.8±1.3 to 2.0±0.9 in the CSP0510-treated group (p＜0.001), and from 4.6±1.1 to 3.5±0.9 in the control group (p=0.075), showing a statistical significance between two groups (p=0.002). Our results in humans were further supported by in vitro and animal experiments. In HaCaT cells treated with compound 48/80 (7.5 μg/ml), CA:TSP (1:1, vol:vol) synergistically suppressed the compound 48/80-induced upregulation of thymic stromal lymphopoietin, nerve grow factor, and calcitonin gene-related peptide. Application of CSP0510 to the dorsal skin of hairless mice for 3 weeks suppressed the oxazolone-induced allergic skin inflammation. Conclusion: In conclusion, CSP0510 lotion has anti-itch and anti-inflammatory activity in the skin, which improves both objective and subjective symptoms of AD.
Abstract
Background: Moisturizers with anti-inflammatory or anti- itch activity should be developed for the safe and effective management of atopic dermatitis (AD). Objective: This study evaluated the efficacy of a newly developed moisturizer, CSP0510 lotion (Twolines Inc., Korea), containing citric acid (CA) and trisodium phosphate (TSP) as active ingredients, in mild to moderate AD. Methods and Results: CSP0510 lotion applied twice daily for 4 weeks to eczematous lesions improved objective and subjective (itch) symptoms of AD. The physician’s global assessment (PGA) score for objective symptoms decreased from 2.5±0.6 before application to 1.3±0.5 after application in the CSP0510-treated group (n=42, p＜0.001). Also, the PGA score decreased from 2.3±0.6 to 1.9±0.5 by vehicle-treated (without CA and TSP) control group (p=0.001), but there was no statistical difference between CSP0510-treated and vehicle-treated groups (p=0.089). The visual analogue scale score for itch decreased from 4.8±1.3 to 2.0±0.9 in the CSP0510-treated group (p＜0.001), and from 4.6±1.1 to 3.5±0.9 in the control group (p=0.075), showing a statistical significance between two groups (p=0.002). Our results in humans were further supported by in vitro and animal experiments. In HaCaT cells treated with compound 48/80 (7.5 μg/ml), CA:TSP (1:1, vol:vol) synergistically suppressed the compound 48/80-induced upregulation of thymic stromal lymphopoietin, nerve grow factor, and calcitonin gene-related peptide. Application of CSP0510 to the dorsal skin of hairless mice for 3 weeks suppressed the oxazolone-induced allergic skin inflammation. Conclusion: In conclusion, CSP0510 lotion has anti-itch and anti-inflammatory activity in the skin, which improves both objective and subjective symptoms of AD.
참고문헌 (23)
- Guttman-Yassky E., "Contrasting pathogenesis of atopic dermatitis and psoriasis--part II : immune cell subsets and therapeutic concepts", J Allergy Clin Immunol, 127, pp.1420~1432 (2011)
- Ostlere LS., "Neuropeptides in the skin of patients with atopic dermatitis", Clin Exp Dermatol, 20, pp.462~467 (1995)
- Scholzen T., "Neuropeptides in the skin : interactions between the neuroendocrine and the skin immune systems", Exp Dermatol, 7, pp.81~96 (1998)
- Wang IJ., "Neuro-mediators as predictors of paediatric atopic dermatitis", Clin Exp Allergy, 38, pp.1302~1308 (2008)
- Yamaguchi J., "Quantitative analysis of nerve growth factor(NGF)in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis", J Dermatol Sci, 53, pp.48~54 (2009)
- Wang YH., "Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses", Clin Exp Allergy, 39, pp.798~806 (2009)
- Takai T, "TSLP expression : cellular sources, triggers, and regulatory mechanisms", Allergol Int, 61, pp.3~17 (2012)
- Zenro Ikezawa, "A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis", Allergy, Asthma & Immunology Research, 2(4), pp.235~246 (2010), 대한천식알레르기학회
- Antúnez C., "Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis", Br J Dermatol, 161, pp.547~553 (2009)
- Park TJ., "Somatosensory organization and behavior in naked mole- rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain", J Comp Neurol, 465, pp.104~120 (2003)
- Salomon J., "The role of selected neuropeptides in pathogenesis of atopic dermatitis", J Eur Acad Dermatol Venereol, 22, pp.223~228 (2008)
- 정충현, "구강 내 사슬알균 종들에 대한 제3인산나트륨과 구연산의 탈부착 효과", 미생물학회지, 44(4), pp.289~292 (2008), 한국미생물학회
- Man MQ., "Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis : structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges", J Invest Dermatol, 128, pp.79~86 (2008)
- 최다인, "Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity in Both an Oxazolone-Induced Contact Dermatitis Mouse Model and Compound 48", 80-Treated HaCaT Cells, 2015, pp.27(2), 142~151[DOI]
- Hanifin JM., "Diagnostic features of atopic dermatitis", Acta Derm Venereol (Stockh), 92(Suppl), pp.S44~S47 (1980)
- Penniston KL., "Quantitative assessment of citric acid in lemon juice, lime juice, and commercially-available fruit juice products", J Endourol, 22, pp.567~570 (2008)
- Xiong H., "Spraying chicken skin with selected chemicals to reduce attached Salmonella typhimurium", J Food Prot, 61, pp.272~275 (1998)
- Lee HJ., "Topical acidic cream prevents the development of atopic dermatitis-and asthma-like lesions in murine model", Exp Dermatol, 23, pp.736~741 (2014)
- Grove G., "An evaluation of the moisturizing and anti-itch effects of a lactic acid and pramoxine hydrochloride cream", Cutis, 73, pp.135~139 (2004)
- Vilaplana J., "Clinical and non-invasive evaluation of 12% ammonium lactate emulsion for the treatment of dry skin in atopic and non-atopic subjects", Acta Derm Venereol, 72, pp.28~33 (1992)
- Darlenski R., "Lactic acid sting test does not differentiate between facial and generalized skin functional impairment in sensitive skin in atopic dermatitis and rosacea", J Dermatol Sci, 76, pp.151~153 (2014)
- Lodén M, "The clinical benefit of moisturizers", J Eur Acad Dermatol Venereol, 19, pp.672~688 (2005)
- Babilas P., "Cosmetic and dermatologic use of alpha hydroxy acids", J Dtsch Dermatol Ges, 10, pp.488~491 (2012)