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Understanding of Pathomechanisms and Clinical Practice for Vitiligo

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초록

Vitiligo is a disease caused by the acquired depletion of melanocytes and/or melanocyte precursor cells in response to genetic and environmental factors, resulting in depigmentation of the entire body. It is roughly divided into segmental and non-segmental vitiligo, and it has been found that abnormalities of melanocytes themselves and dysregulation of autoimmune responses to melanocytes are greatly involved in the pathology of non-segmental vitiligo. Segmental vitiligo pathology is largely unknown; however, it has been suggested that it may be caused by skin or melanocyte mosaicism. Treatments for vitiligo include topical therapy, ultraviolet therapy, and surgical transplantation, and it is extremely important to correctly understand the pathology to perform optimal treatment. In recent years, the development of vitiligo treatments using Janus kinase (JAK) inhibitors has progressed rapidly. We herein outline the latest pathology of vitiligo, from general vitiligo treatment to the progress of clinical trials using JAK inhibitors, along with what clinicians should consider in archiving precision medicine, including my own ideas thereon.

Abstract

Vitiligo is a disease caused by the acquired depletion of melanocytes and/or melanocyte precursor cells in response to genetic and environmental factors, resulting in depigmentation of the entire body. It is roughly divided into segmental and non-segmental vitiligo, and it has been found that abnormalities of melanocytes themselves and dysregulation of autoimmune responses to melanocytes are greatly involved in the pathology of non-segmental vitiligo. Segmental vitiligo pathology is largely unknown; however, it has been suggested that it may be caused by skin or melanocyte mosaicism. Treatments for vitiligo include topical therapy, ultraviolet therapy, and surgical transplantation, and it is extremely important to correctly understand the pathology to perform optimal treatment. In recent years, the development of vitiligo treatments using Janus kinase (JAK) inhibitors has progressed rapidly. We herein outline the latest pathology of vitiligo, from general vitiligo treatment to the progress of clinical trials using JAK inhibitors, along with what clinicians should consider in archiving precision medicine, including my own ideas thereon.

참고문헌 (60)

  1. Lerner AB, "On the etiology of vitiligo and gray hair", Am J Med, 51, pp.141~147 (1971)
  2. Alikhan A, "Vitiligo : a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up", J Am Acad Dermatol, 65, pp.473~491 (2011)
  3. Bergqvist C, "Vitiligo : a review", Dermatology, 236, pp.571~592 (2020)
  4. Narita T, "Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families", Allergol Int, 60, pp.505~508 (2011)
  5. Majumder PP, "Pattern of familial aggregation of vitiligo", Arch Dermatol, 129, pp.994~998 (1993)
  6. Ezzedine K, "Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes", Pigment Cell Melanoma Res, 27, pp.134~139 (2014)
  7. Roberts GHL, "The genetic architecture of vitiligo", Pigment Cell Melanoma Res, 33, pp.8~15 (2020)
  8. Kim HJ, "Familial risk of vitiligo among first-degree relatives and spouses : a population-based cohort study in Korea", J Invest Dermatol, 141, pp.921~924 (2021)
  9. Le Poole IC, "Myron Gordon award paper : microbes, T-cell diversity and pigmentation", Pigment Cell Melanoma Res, 34, pp.244~255 (2021)
  10. Spritz RA, "Genetics of vitiligo", Dermatol Clin, 35, pp.245~255 (2017)
  11. Chen J, "Mechanisms of melanocyte death in vitiligo", Med Res Rev, 41, pp.1138~1166 (2021)
  12. Shi J, "Pyroptosis : gasdermin-mediated programmed necrotic cell death", Trends Biochem Sci, 42, pp.245~254 (2017)
  13. Zhou Z, "Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells", Science, 368, pp.eaaz7548~ (2020)
  14. Holze C, "Oxeiptosis, a ROS-induced caspase-independent apoptosislike cell-death pathway", Nat Immunol, 19, pp.130~140 (2018)
  15. Cui T, "HSF1-dependent autophagy activation contributes to the survival of melanocytes under oxidative stress in vitiligo", J Invest Dermatol, 142, pp.1659~1669 (2022)
  16. Wagner RY, "Altered E-cadherin levels and distribution in melanocytes precede clinical manifestations of vitiligo", J Invest Dermatol, 135, pp.1810~1819 (2015)
  17. Zhang Y, "Oxidative stressinduced calreticulin expression and translocation : new insights into the destruction of melanocytes", J Invest Dermatol, 134, pp.183~191 (2014)
  18. Cheuk S, "CD49a expression defines tissue-resident CD8+T cells poised for cytotoxic function in human skin", Immunity, 46, pp.287~300 (2017)
  19. Richmond JM, "Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo", Sci Transl Med, 10, pp.eaam7710~ (2018)
  20. Xu Z, "Anatomically distinct fibroblast subsets determine skin autoimmune patterns", Nature, 601, pp.118~124 (2022)
  21. Boniface K, "Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3", J Invest Dermatol, 138, pp.355~364 (2018)
  22. Toosi S, "Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8", J Invest Dermatol, 132, pp.2601~2609 (2012)
  23. Tulic MK, "Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo", Nat Commun, 10, pp.2178~ (2019)
  24. Peralta-Pedrero ML, "Systematic review of clinimetric instruments to determine the severity of non-segmental vitiligo", Australas J Dermatol, 60, pp.e178~e185 (2019)
  25. Bae JM, "Phototherapy for vitiligo : a systematic review and meta-analysis", JAMA Dermatol, 153, pp.666~674 (2017)
  26. van Geel N, "Clinical significance of Koebner phenomenon in vitiligo", Br J Dermatol, 167, pp.1017~1024 (2012)
  27. Thakur V, "Vitiligo : translational research and effective therapeutic strategies", Pigment Cell Melanoma Res, 34, pp.814~826 (2021)
  28. Benzekri L, "Vitiligo Potential Repigmentation Index : a simple clinical score that might predict the ability of vitiligo lesions to repigment under therapy", Br J Dermatol, 168, pp.1143~1146 (2013)
  29. Drake LA, "Guidelines of care for vitiligo. American Academy of Dermatology", J Am Acad Dermatol, 35, pp.620~626 (1996)
  30. Gawkrodger DJ, "Guideline for the diagnosis and management of vitiligo", Br J Dermatol, 159, pp.1051~1076 (2008)
  31. Taieb A, "Guidelines for the management of vitiligo : the European Dermatology Forum consensus", Br J Dermatol, 168, pp.5~19 (2013)
  32. Oiso N, "Guidelines for the diagnosis and treatment of vitiligo in Japan", J Dermatol, 40, pp.344~354 (2013)
  33. Mohammad TF, "The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo", J Am Acad Dermatol, 76, pp.879~888 (2017)
  34. Singh C, "Comparison between autologous noncultured extracted hair follicle outer root sheath cell suspension and autologous noncultured epidermal cell suspension in the treatment of stable vitiligo : a randomized study", Br J Dermatol, 169, pp.287~293 (2013)
  35. Ju HJ, "Surgical interventions for patients with vitiligo : a systematic review and meta-analysis", JAMA Dermatol, 157, pp.307~316 (2021)
  36. Hu M, "The addition of topical calcipotriol to phototherapy enhance the efficacy of treatment in patients with vitiligo : a systematic review and meta-analysis", Int Immunopharmacol, 98, pp.107910~ (2021)
  37. Rodríguez-Martín M, "Randomized, double-blind clinical trial to evaluate the efficacy of topical tacalcitol and sunlight exposure in the treatment of adult nonsegmental vitiligo", Br J Dermatol, 160, pp.409~414 (2009)
  38. Das A, "Use of topical corticosteroids in dermatology : an evidence-based approach", Indian J Dermatol, 62, pp.237~250 (2017)
  39. Kandil E, "Treatment of vitiligo with 0-1 per cent betamethasone 17-valerate in isopropyl alcohol--a double-blind trial", Br J Dermatol, 91, pp.457~460 (1974)
  40. Lee KY, "Endothelin-1 enhances the proliferation of normal human melanocytes in a paradoxical manner from the TNF-α-inhibited condition, but tacrolimus promotes exclusively the cellular migration without proliferation : a proposed action mechanism for combination therapy of phototherapy and topical tacrolimus in vitiligo treatment", J Eur Acad Dermatol Venereol, 27, pp.609~616 (2013)
  41. Lan CC, "FK506promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes : possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo", Br J Dermatol, 153, pp.498~505 (2005)
  42. Huang H, "Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells", Chin Med J(Engl), 127, pp.2966~2971 (2014)
  43. Jung H, "FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes", Pigment Cell Melanoma Res, 29, pp.199~209 (2016)
  44. Yardman-Frank JM, "Skin pigmentation and its control : from ultraviolet radiation to stem cells", Exp Dermatol, 30, pp.560~571 (2021)
  45. Whitton M, "Evidence-based management of vitiligo : summary of a Cochrane systematic review", Br J Dermatol, 174, pp.962~969 (2016)
  46. Kumaran MS, "Effect of topical calcipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo", J Eur Acad Dermatol Venereol, 20, pp.269~273 (2006)
  47. Westerhof W, "Left-right comparison study of the combination of fluticasone propionate and UV-A vs. either fluticasone propionate or UV-A alone for the long-term treatment of vitiligo", Arch Dermatol, 135, pp.1061~1066 (1999)
  48. Sassi F, "Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck", Br J Dermatol, 159, pp.1186~1191 (2008)
  49. Lee JH, "Treatment outcomes of topical calcineurin inhibitor therapy for patients with vitiligo : a systematic review and meta-analysis", JAMA Dermatol, 155, pp.929~938 (2019)
  50. Bae JM, "The efficacy of 308-nm excimer laser", light(EL)and topical agent combination therapy versus EL monotherapy for vitiligo : a systematic review and metaanalysis of randomized controlled trials(RCTs), 2016, pp.74, 907~915
  51. Ju HJ, "The longterm risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25, 694patients with vitiligo", J Am Acad Dermatol, 84, pp.1619~1627 (2021)
  52. Li R, "Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo : a meta-analysis", Photodermatol Photoimmunol Photomed, 33, pp.22~31 (2017)
  53. Barman KD, "A comparative study of punch grafting followed by topical corticosteroid versus punch grafting followed by PUVA therapy in stable vitiligo", Dermatol Surg, 30, pp.49~53 (2004)
  54. van Geel N, "Double-blind placebo-controlled study of autologous transplanted epidermal cell suspensions for repigmenting vitiligo", Arch Dermatol, 140, pp.1203~1208 (2004)
  55. Zhu B, "Comparison of NBUVB combination therapy regimens for vitiligo : a systematic review and network meta-analysis", J Cosmet Dermatol, 22, pp.1083~1098 (2023)
  56. Martins C, "Vitiligo skin T cells are prone to produce type 1 and type 2 cytokines to induce melanocyte dysfunction and epidermal inflammatory response through Jak signaling", J Invest Dermatol, 142, pp.1194~1205 (2022)
  57. Strassner JP, "Understanding mechanisms of autoimmunity through translational research in vitiligo", Curr Opin Immunol, 43, pp.81~88 (2016)
  58. Liu LY, "Tofacitinib for the treatment of severe alopecia areata and variants : a study of 90 patients", J Am Acad Dermatol, 76, pp.22~28 (2017)
  59. Rosmarin D, "Ruxolitinib cream for treatment of vitiligo : a randomised, controlled, phase 2 trial", Lancet, 396, pp.110~120 (2020)
  60. Qi F, "Janus kinase inhibitors in the treatment of vitiligo : a review", Front Immunol, 12, pp.790125~ (2021)

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