Up-and-Coming Drugs for the Treatment of Vitiligo
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Vitiligo is a chronic autoimmune disease that causes depigmented patches on the skin. It affects 0.5%–2.0% of the global population. It goes beyond physical appearance, often leading to stig- matization, low self-esteem, and depression, burdening patients with psychosocial challenges. The pathogenesis of vitiligo involves the loss of melanocytes due to autoreactive CD8+ T cells, triggered by environmental stressors and exacerbated by cellular vulnerabilities and immune responses. The release of danger signals and pro-inflammator y factors initiates an immune cas- cade perpetuating melanocyte destruction, mainly driven by interferon-γ and the C-X-C motif chemokine ligand 9/10-chemokine receptor 3 axis. Long-lasting tissue-resident memor y T cells (Trms) and cytokines contribute to lesion persistence. Current treatments focus on topical ste- roids and tacrolimus, systemic steroids, and phototherapies, but their efficacy remains subop- timal, necessitating the development of new therapeutic options. Building on recent advance- ments in understanding the immunological mechanisms in vitiligo pathogenesis, with the ini- tiation of Food and Drug Administration approval of topical ruxolitinib, various potential treat- ment options such as JAK inhibitors, cytokine blockers, and Trm or regulator y T cell targeting agents are being clinically researched and anticipated for vitiligo based on both preclinical and clinical data. This review aims to categorize and summarize the diverse investigational drugs currently undergoing clinical trials for vitiligo. By examining clinical outcomes, it is anticipated that this review will bring hope to dermatologists and patients regarding vitiligo, a condition that has historically posed challenges and transform it into a realm of potential possibilities.
Abstract
Vitiligo is a chronic autoimmune disease that causes depigmented patches on the skin. It affects 0.5%–2.0% of the global population. It goes beyond physical appearance, often leading to stig- matization, low self-esteem, and depression, burdening patients with psychosocial challenges. The pathogenesis of vitiligo involves the loss of melanocytes due to autoreactive CD8+ T cells, triggered by environmental stressors and exacerbated by cellular vulnerabilities and immune responses. The release of danger signals and pro-inflammator y factors initiates an immune cas- cade perpetuating melanocyte destruction, mainly driven by interferon-γ and the C-X-C motif chemokine ligand 9/10-chemokine receptor 3 axis. Long-lasting tissue-resident memor y T cells (Trms) and cytokines contribute to lesion persistence. Current treatments focus on topical ste- roids and tacrolimus, systemic steroids, and phototherapies, but their efficacy remains subop- timal, necessitating the development of new therapeutic options. Building on recent advance- ments in understanding the immunological mechanisms in vitiligo pathogenesis, with the ini- tiation of Food and Drug Administration approval of topical ruxolitinib, various potential treat- ment options such as JAK inhibitors, cytokine blockers, and Trm or regulator y T cell targeting agents are being clinically researched and anticipated for vitiligo based on both preclinical and clinical data. This review aims to categorize and summarize the diverse investigational drugs currently undergoing clinical trials for vitiligo. By examining clinical outcomes, it is anticipated that this review will bring hope to dermatologists and patients regarding vitiligo, a condition that has historically posed challenges and transform it into a realm of potential possibilities.
참고문헌 (135)
- Frisoli ML, "Vitiligo : mechanisms of pathogenesis and treatment", Annu Rev Immunol, 38, pp.621~648 (2020)
- Picardo M, "Vitiligo", Nat Rev Dis Primers, 1, pp.15011~ (2015)
- Krüger C, "A review of the worldwide prevalence of vitiligo in children", adolescents and adults, 2012, pp.51, 1206~1212
- Lee H, "Prevalence of vitiligo and associated comorbidities in Korea", Yonsei Med J, 56, pp.719~725 (2015)
- Ezzedine K, "Psychosocial effects of vitiligo : a systematic literature review", Am J Clin Dermatol, 22, pp.757~774 (2021)
- Bibeau K, "Mental health and psychosocial quality-of-life burden among patients with vitiligo : findings from the global VALIANT study", JAMA Dermatol, 159, pp.1124~1128 (2023)
- Sehgal VN, "Vitiligo : compendium of clinico-epidemiological features", Indian J Dermatol Venereol Leprol, 73, pp.149~156 (2007)
- Seneschal J, "Worldwide expert recommendations for the diagnosis and management of vitiligo : Position statement from the International Vitiligo Task Force-Part 2 : specific treatment recommendations", J Eur Acad Dermatol Venereol, 37, pp.2185~2195 (2023)
- van Geel N, "Worldwide expert recommendations for the diagnosis and management of vitiligo : Position statement from the International Vitiligo Task Force Part 1 : towards a new management algorithm", J Eur Acad Dermatol Venereol, 37, pp.2173~2184 (2023)
- Richmond JM, "Innate immune mechanisms in vitiligo : danger from within", Curr Opin Immunol, 25, pp.676~682 (2013)
- Thulasingam S, "miR-27b*, an oxidative stress-responsive microRNA modulates nuclear factor-kB pathway in RAW 264. 7 cells", Mol Cell Biochem, 352, pp.181~188 (2011)
- Ahn Y, "ATP-P2X7-induced inflammasome activation contributes to melanocyte death and CD8+ T-cell trafficking to the skin in vitiligo", J Invest Dermatol, 140, pp.1794~1804 (2020)
- Kim JY, "Impact of high-mobility group box 1 on melanocytic survival and its involvement in the pathogenesis of vitiligo", Br J Dermatol, 176, pp.1558~1568 (2017)
- Cui T, "Oxidative stress-induced HMGB1 release from melanocytes : a paracrine mechanism underlying the cutaneous inflammation in vitiligo", J Invest Dermatol, 139, pp.2174~2184 (2019)
- Xie H, "Vitiligo : how do oxidative stress-induced autoantigens trigger autoimmunity?", J Dermatol Sci, 81, pp.3~9 (2016)
- Tulic MK, "Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo", Nat Commun, 10, pp.2178~ (2019)
- Harris JE, "A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8+ T-cell accumulation in the skin", J Invest Dermatol, 132, pp.1869~1876 (2012)
- Richmond JM, "Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo", J Invest Dermatol, 139, pp.769~778 (2019)
- Richmond JM, "Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo", Sci Transl Med, 10, pp.eaam7710~ (2018)
- Boukhedouni N, "Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo", JCI Insight, 5, pp.e133772~ (2020)
- Dwivedi M, "Regulatory T cells in vitiligo : implications for pathogenesis and therapeutics", Autoimmun Rev, 14, pp.49~56 (2015)
- Lee EJ, "ISG15-USP18 dysregulation by oxidative stress promotes IFN-γ secretion from CD8+ T cells in vitiligo", J Invest Dermatol, 144, pp.273~283 (2024)
- Tanemura A, "Understanding of pathomechanisms and clinical practice for vitiligo", Ann Dermatol, 35, pp.333~341 (2023)
- Villarino AV, "Mechanisms of Jak", STAT signaling in immunity and disease, 2015, pp.194, 21~27
- Rashighi M, "Interfering with the IFN-γ", CXCL10 pathway to develop new targeted treatments for vitiligo, 2015, pp.3, 343~
- Platanias LC, "Mechanisms of type-I-and type-II-interferon-mediated signalling", Nat Rev Immunol, 5, pp.375~386 (2005)
- Chen X, "Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo", Free Radic Biol Med, 139, pp.80~91 (2019)
- Jacquemin C, "Heat shock protein 70 potentiates interferon alpha production by plasmacytoid dendritic cells : relevance for cutaneous lupus and vitiligo pathogenesis", Br J Dermatol, 177, pp.1367~1375 (2017)
- Xu Z, "Anatomically distinct fibroblast subsets determine skin autoimmune patterns", Nature, 601, pp.118~124 (2022)
- Mesa RA, "Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis", IDrugs, 13, pp.394~403 (2010)
- Vannucchi AM, "Ruxolitinib versus standard therapy for the treatment of polycythemia vera", N Engl J Med, 372, pp.426~435 (2015)
- Harris JE, "Rapid skin repigmentation on oral ruxolitinib in a patient with coexistent vitiligo and alopecia areata(AA)", J Am Acad Dermatol, 74, pp.370~371 (2016)
- Rosmarin D, "Ruxolitinib cream for treatment of vitiligo : a randomised, controlled, phase 2 trial", Lancet, 396, pp.110~120 (2020)
- Rosmarin D, "Two phase 3, randomized, controlled trials of ruxolitinib cream for vitiligo", N Engl J Med, 387, pp.1445~1455 (2022)
- Wolkerstorfer A, "519-Efficacy of prolonged ruxolitinib cream treatment for vitiligo among patients with limited or no initial response at 6 months", Br J Dermatol, 190(Supplement_2), pp.ii66~ii68 (2024)
- Pandya AG, "Addition of narrow-band UVB phototherapy to ruxolitinib cream in patients with vitiligo", J Invest Dermatol, 142, pp.3352~3355 (2022)
- "A study to evaluate the safety and efficacy of ruxolitinib cream with phototherapy in participants with vitiligo" (2022)[URL]
- "A study to assess the safety and efficacy of ruxolitinib cream in participants with genital vitiligo" (2023)[URL]
- Harrington R, "JAK inhibitors in rheumatoid arthritis : an evidence-based review on the emerging clinical data", J Inflamm Res, 13, pp.519~531 (2020)
- Craiglow BG, "Tofacitinib citrate for the treatment of vitiligo : a pathogenesis-directed therapy", JAMA Dermatol, 151, pp.1110~1112 (2015)
- Liu LY, "Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure", J Am Acad Dermatol, 77, pp.675~682 (2017)
- Azzolino V, "Jak inhibitors reverse vitiligo in mice but do not deplete skin resident memory T cells", J Invest Dermatol, 141, pp.182~184 (2021)
- McKesey J, "A pilot study of 2% tofacitinib cream with narrowband ultraviolet B for the treatment of facial vitiligo", J Am Acad Dermatol, 81, pp.646~648 (2019)
- "Role of tofacitinib in vitiligo patients (ETV)" (2022)[URL]
- Zhang J, "Application of baricitinib in dermatology", J Inflamm Res, 15, pp.1935~1941 (2022)
- Mumford BP, "Repigmentation of vitiligo with oral baricitinib", Australas J Dermatol, 61, pp.374~376 (2020)
- Dong J, "Baricitinib is effective in treating progressing vitiligo in vivo and in vitro", Dose Response, 20, pp.15593258221105370~ (2022)
- Li C, "Efficacy and safety of Janus kinase inhibitors for the treatment of atopic dermatitis : a systematic review and meta-analysis", Dermatology, 238, pp.725~735 (2022)
- "Evaluation of effect and tolerance of the association of baricitinib and phototherapy versus phototherapy in adults with progressive vitiligo" (2021)[URL]
- Su X, "Efficacy and tolerability of oral upadacitinib monotherapy in patients with recalcitrant vitiligo", J Am Acad Dermatol, 89, pp.1257~1259 (2023)
- Pan T, "Concurrent vitiligo and atopic dermatitis successfully treated with upadacitinib : a case report", J Dermatolog Treat, 34, pp.2200873~ (2023)
- Ezzedine K, "500-Patient-reported outcomes following 24 weeks of treatment with upadacitinib in adults with non-segmental vitiligo : results from a phase 2, randomized, double-blind, dose-ranging study", Br J Dermatol, 190(Supplement_2), pp.ii64~ii65 (2024)
- "A study to assess adverse events and effectiveness of upadacitinib oral tablets in adult and adolescent participants with vitiligo" (2023)[URL]
- Ezzedine K, "Efficacy and safety of oral ritlecitinib for the treatment of active nonsegmental vitiligo : a randomized phase 2b clinical trial", J Am Acad Dermatol, 88, pp.395~403 (2023)
- Roskoski R Jr, "Properties of FDA-approved small molecule protein kinase inhibitors : a 2024 update", Pharmacol Res, 200, pp.107059~ (2024)
- Dainichi T, "Alopecia areata : what’s new in the diagnosis and treatment with JAK inhibitors?", J Dermatol, 51, pp.196~209 (2024)
- Cheuk S, "CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin", Immunity, 46, pp.287~300 (2017)
- Mackay LK, "The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin", Nat Immunol, 14, pp.1294~1301 (2013)
- Xu H, "PF-06651600, a dual JAK3", TEC family kinase inhibitor, 2019, pp.14, 1235~1242
- "A 52-week study of ritlecitinib oral capsules in adults and adolescents with nonsegmental vitiligo (active and stable) tranquillo" (2022)[URL]
- "A study of ATI-50002 topical solution for the treatment of vitiligo" (2018)[URL]
- Yagi K, "Two cases of vitiligo vulgaris treated with topical Janus kinase inhibitor delgocitinib", Australas J Dermatol, 62, pp.433~434 (2021)
- Murakami K, "Successful management of severe alopecia areata and vitiligo using topical delgocitinib and a 308-nm excimer laser", Eur J Dermatol, 33, pp.428~430 (2023)
- octan-8-yl)methanone(PF-06700841), "J Med Chem", 2018, 8597~8612
- "A phase 2b study to evaluate the efficacy and safety profile of PF-06651600 and PF-06700841 in active non-segmental vitiligo subjects" (2018)[URL]
- Kirby JS, "Efficacy and safety of the oral Janus kinase 1 inhibitor povorcitinib(INCB054707)in patients with hidradenitis suppurativa in a phase 2, randomized, double-blind, dose-ranging, placebo-controlled study", J Am Acad Dermatol, 90, pp.521~529 (2024)
- "A study to evaluate efficacy and safety of povorcitinib in participants with nonsegmental vitiligo (STOP-V1)" (2023)[URL]
- "A study to evaluate efficacy and safety of povorcitinib in participants with nonsegmental vitiligo (STOP-V2)" (2023)[URL]
- "A study to evaluate the efficacy and safety of INCB054707 in participants with vitiligo" (2021)[URL]
- "Safety and efficacy of ARQ-252 cream 0.3% in subjects with non-segmental facial vitiligo" (2021)[URL]
- "Assess the efficacy and safety of SHR0302 ointment in adult patients with vitiligo" (2020)[URL]
- Zhou C, "A randomized, double-blind, placebo-controlled phase II study to evaluate the efficacy and safety of ivarmacitinib(SHR0302)in adult patients with moderate-to-severe alopecia areata", J Am Acad Dermatol, 89, pp.911~919 (2023)
- Cavalié M, "Maintenance therapy of adult vitiligo with 0. 1% tacrolimus ointment : a randomized, double blind, placebo-controlled study", J Invest Dermatol, 135, pp.970~974 (2015)
- Mosenson JA, "HSP70i is a critical component of the immune response leading to vitiligo", Pigment Cell Melanoma Res, 25, pp.88~98 (2012)
- Kato H, "Emerging biologic therapies for systemic lupus erythematosus", Curr Opin Rheumatol, 36, pp.169~175 (2024)
- "Efficacy and tolerance of the association of anifrolumab (300 mg) IV every four weeks and phototherapy versus phototherapy in adults with progressive vitiligo" (2023)[URL]
- Bertolotti A, "Type I interferon signature in the initiation of the immune response in vitiligo", Pigment Cell Melanoma Res, 27, pp.398~407 (2014)
- Riding RL, "Type I interferon signaling limits viral vector priming of CD8+ T cells during initiation of vitiligo and melanoma immunotherapy", Pigment Cell Melanoma Res, 34, pp.683~695 (2021)
- Atwa MA, "Elevated serum level of interleukin-15 in vitiligo patients and its correlation with disease severity but not activity", J Cosmet Dermatol, 20, pp.2640~2644 (2021)
- Cellier C, "Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease : a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study", Lancet Gastroenterol Hepatol, 4, pp.960~970 (2019)
- "Amgen. Evaluation of AMG 714 for vitiligo (REVEAL)" (2020)[URL]
- Spritz RA, "Recent progress in the genetics of generalized vitiligo", J Genet Genomics, 38, pp.271~278 (2011)
- Tahvildari M, "Low-dose IL-2 therapy in transplantation, autoimmunity, and inflammatory diseases", J Immunol, 203, pp.2749~2755 (2019)
- Lykhopiy V, ""IL-2 immunotherapy for targeting regulatory T cells in autoimmunity"", Genes Immun, 24, pp.248~262 (2023)
- "A clinical study of MK-6194 for the treatment of vitiligo (MK-6194-007)" (2023)[URL]
- Speeckaert R, "Targeting CTLA-4, PD-L1 and IDO to modulate immune responses in vitiligo", Exp Dermatol, 26, pp.630~634 (2017)
- Maxwell L, "Abatacept for rheumatoid arthritis", Cochrane Database Syst Rev, 2009, pp.CD007277~ (2009)
- Dwivedi M, "Decreased regulatory T-cells and CD4+", CD8+ ratio correlate with disease onset and progression in patients with generalized vitiligo, 2013, pp.26, 586~591
- "Open-label pilot study of abatacept for the treatment of vitiligo" (2015)[URL]
- Li H, "Phosphodiesterase-4 inhibitors for the treatment of inflammatory diseases", Front Pharmacol, 9, pp.1048~ (2018)
- Ozturk DG, "MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress", Autophagy, 15, pp.375~390 (2019)
- Hida T, "Elucidation of melanogenesis cascade for identifying pathophysiology and therapeutic approach of pigmentary disorders and melanoma", Int J Mol Sci, 21, pp.6129~ (2020)
- Sakkas LI, "Phosphodiesterase 4 inhibitors in immune-mediated diseases : mode of action, clinical applications, current and future perspectives", Curr Med Chem, 24, pp.3054~3067 (2017)
- Khemis A, "Apremilast in combination with narrowband UVB in the treatment of vitiligo : a 52-week monocentric prospective randomized placebo-controlled study", J Invest Dermatol, 140, pp.1533~1537 (2020)
- Sharma S, "Apremilast add-on benefits over conventional drugs(ABCD)in unstable non-segmental vitiligo : a 12-week single-center randomized controlled trial", Cureus, 15, pp.e37180~ (2023)
- Kim HJ, "Combination of apremilast and narrowband ultraviolet B light in the treatment of generalized vitiligo in skin phototypes IV to VI : a randomized split-body pilot study", J Am Acad Dermatol, 85, pp.1657~1660 (2021)
- Majid I, "Apremilast is effective in controlling the progression of adult vitiligo : a case series", Dermatol Ther, 32, pp.e12923~ (2019)
- Kim HJ, "Apremilast and narrowband ultraviolet B combination therapy suppresses Th17 axis and promotes melanogenesis in vitiligo skin : a randomized, split-body, pilot study in skin types IV-VI", Arch Dermatol Res, 315, pp.215~221 (2023)
- Tam I, "Repigmentation in a patient with vitiligo on crisaborole 2% ointment", JAAD Case Rep, 11, pp.99~101 (2021)
- Sun X, "Successful treatment of vitiligo with crisaborole ointment : a report of two cases", Br J Dermatol, 188, pp.436~437 (2023)
- "Study of efficacy, safety and tolerability of crisaborole and PF-07038124 with and without NBUVB in vitiligo" (2022)[URL]
- Langendonk JG, "Afamelanotide for erythropoietic protoporphyria", N Engl J Med, 373, pp.48~59 (2015)
- Minder EI, "Pharmacokinetics and pharmacodynamics of afamelanotide and its clinical use in treating dermatologic disorders", Clin Pharmacokinet, 56, pp.815~823 (2017)
- Fabrikant J, "A review and update on melanocyte stimulating hormone therapy : afamelanotide", J Drugs Dermatol, 12, pp.775~779 (2013)
- Grimes PE, "The efficacy of afamelanotide and narrowband UV-B phototherapy for repigmentation of vitiligo", JAMA Dermatol, 149, pp.68~73 (2013)
- Lim HW, "Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo : a randomized multicenter trial", JAMA Dermatol, 151, pp.42~50 (2015)
- Toh JJ, "Afamelanotide implants and narrow-band ultraviolet B phototherapy for the treatment of nonsegmental vitiligo in Asians", J Am Acad Dermatol, 82, pp.1517~1519 (2020)
- Passeron T, "Indications and limitations of afamelanotide for treating vitiligo", JAMA Dermatol, 151, pp.349~350 (2015)
- Lim HW, "Indications and limitations of afamelanotide for treating vitiligo-reply", JAMA Dermatol, 151, pp.350~ (2015)
- "A study to assess the changes in pigmentation and safety of afamelanotide in patients with vitiligo on the face" (2022)[URL]
- "A study to compare the efficacy and safety of SCENESSE and narrow-band ultraviolet (NB-UVB) light versus NB-UVB light alone in patients with vitiligo" (2023)[URL]
- Galloway GD, "Periocular cutaneous pigmentary changes associated with bimatoprost use", Arch Ophthalmol, 123, pp.1609~1610 (2005)
- Prota G, "Latanoprost stimulates eumelanogenesis in iridial melanocytes of cynomolgus monkeys", Pigment Cell Res, 13, pp.147~150 (2000)
- Nowroozpoor Dailami K, "Efficacy of topical latanoprost in the treatment of eyelid vitiligo : a randomized, double-blind clinical trial study", Dermatol Ther, 33, pp.e13175~ (2020)
- Neinaa YM, "A comparative study of combined microneedling and narrowband ultraviolet B phototherapy versus their combination with topical latanoprost in the treatment of vitiligo", Dermatol Ther, 34, pp.e14813~ (2021)
- Silpa-Archa N, "The efficacy of bimatoprost ophthalmic solution combined with NB-UVB phototherapy in non-segmental and segmental vitiligo : a single-blind randomized controlled study", Sci Rep, 13, pp.6438~ (2023)
- Kanokrungsee S, "Clinical outcomes of topical bimatoprost for nonsegmental facial vitiligo : a preliminary study", J Cosmet Dermatol, 20, pp.812~818 (2021)
- Nagui NA, "Assessment of prostaglandin F2-alpha(PGF2α)in lesional and nonlesional skin of vitiligo patients", Int J Dermatol, 61, pp.1390~1396 (2022)
- Bastonini E, "A protective role for autophagy in vitiligo", Cell Death Dis, 12, pp.318~ (2021)
- Saxton RA, "mTOR signaling in growth, metabolism, and disease", Cell, 168, pp.960~976 (2017)
- Nie HQ, "Relationship between autophagy of melanocytes in patients with vitiligo and clinical types", Zhonghua Yi Xue Za Zhi, 96, pp.2064~2069 (2016)
- Lai ZW, "Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications : a single-arm, open-label, phase 1", 2 trial, 2018, pp.391, 1186~1196
- Chatterjee S, "A quantitative increase in regulatory T cells controls development of vitiligo", J Invest Dermatol, 134, pp.1285~1294 (2014)
- "Daily topical rapamycin for vitiligo" (2022)[URL]
- "Evaluating the efficacy and safety of metformin in vitiligo" (2023)[URL]
- Ursini F, "Metformin and autoimmunity : a"New Deal"of an old drug", Front Immunol, 9, pp.1236~ (2018)
- Lee S, "P099: An identification of potential therapeutics for vitiligo by mass screening for 1732 medicines in Korean National Health Insurance database", Proceedings of Korean Dermatological Association Meeting Program Book, pp.422~ (2020), Korean Dermatological Association
- Pearce EL, "Metabolic pathways in immune cell activation and quiescence", Immunity, 38, pp.633~643 (2013)
- O’Neill LA, "Metabolism of inflammation limited by AMPK and pseudo-starvation", Nature, 493, pp.346~355 (2013)
- Yin Y, "Normalization of CD4+ T cell metabolism reverses lupus", Sci Transl Med, 7, pp.274~ (2015)
- Skurkovich S, "Treatment of alopecia areata with anti-interferon-gamma antibodies", J Investig Dermatol Symp Proc, 10, pp.283~284 (2005)
- Rashighi M, "CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo", Sci Transl Med, 6, pp.223~ (2014)
- Richmond JM, "CXCR3 depleting antibodies prevent and reverse vitiligo in mice", J Invest Dermatol, 137, pp.982~985 (2017)
- Lin X, "The possible role of Wnt", β-catenin signalling in vitiligo treatment, 2023, pp.37, 2208~2221
- Tang L, "Vitamin D protects human melanocytes against oxidative damage by activation of Wnt", β-catenin signaling, 2018, pp.98, 1527~1537
