Clinical Course of Segmental Vitiligo: A Retrospective Study of Eighty-Seven Patients
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Background: Vitiligo is an acquired disorder characterizedby a progressive loss of melanocytes, which is difficult tomanage and has an unknown prognosis. The subtype ofsegmental vitiligo (SV) has been established but it has notbeen adequately characterized. Objective: To collect longtermfollow-up data for evaluating the clinical course of SV. Methods: This study included 87 patients who werediagnosed with SV and were monitored at a clinic. Patientswere classified into the following three groups according todisease activity. Results: Among the patients with SV, 63.2%had stable disease, 14.9% had disease recurrence betweentwo and four years after disease onset, and 21.8% haddisease recurrence at four or more than four years afterdisease onset. Among the 44 patients (50.2%) who weremonitored continuously over a four-year period, 19 (43.2%)experienced a recurrence at four or more than four years afterdisease onset. Conclusion: Our results suggest that, contraryto previous reports, some patients with SV may notexperience disease stability over an extended period of time. Disease recurrence can occur after years of stability, and wepropose that long-term follow-up data can be used tocharacterize SV. This information about the clinical course ofSV has implications for treatment and prognosis.
Abstract
Background: Vitiligo is an acquired disorder characterizedby a progressive loss of melanocytes, which is difficult tomanage and has an unknown prognosis. The subtype ofsegmental vitiligo (SV) has been established but it has notbeen adequately characterized. Objective: To collect longtermfollow-up data for evaluating the clinical course of SV. Methods: This study included 87 patients who werediagnosed with SV and were monitored at a clinic. Patientswere classified into the following three groups according todisease activity. Results: Among the patients with SV, 63.2%had stable disease, 14.9% had disease recurrence betweentwo and four years after disease onset, and 21.8% haddisease recurrence at four or more than four years afterdisease onset. Among the 44 patients (50.2%) who weremonitored continuously over a four-year period, 19 (43.2%)experienced a recurrence at four or more than four years afterdisease onset. Conclusion: Our results suggest that, contraryto previous reports, some patients with SV may notexperience disease stability over an extended period of time. Disease recurrence can occur after years of stability, and wepropose that long-term follow-up data can be used tocharacterize SV. This information about the clinical course ofSV has implications for treatment and prognosis.
참고문헌 (12)
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