Clinical Evaluation of Conditioned Media of Human Umbilical Cord Blood Mesenchymal Stem Cells for Improvement of Symptoms of Sensitive Skin: Prospective, Single Blinded, Split-face Study
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Background: The exact definition of sensitive skin is not established yet. Since its high prevalence and significant inf luence on quality of life, it has become an important topic of research. Among various ingredients, conditioned media from umbilical cord blood-derived mesenchymal stem cells (UCB-MSC-CM) can be a promising source for the treatment of sensitive skin. Objective: We evaluated the efficacy and safety of UCB-MSC-CM on patients with sensitive skin. Methods: We designed a randomized, single blinded, prospective, split-face comparison study and enrolled thirty patients. All patients underwent nonablative fractional laser over the entire face before UCB-MSC-CM or normal saline was applied. Each facial area was randomly assigned to undergo treatment with either UCB-MSC-CM or normal saline. We performed three sessions at two-week intervals, and final results were assessed on six weeks after the last session. As an outcome measure, we evaluated a five-point global assessment scale, transepidermal water loss (TEWL), erythema index (EI) and Sensitive Scale-10. Twen- ty seven subjects were included in final analysis. Results: The treated side exhibited greater improvement compared to the untreated side based on a five-point global assessment scale. TEWL, EI of the treated side were significant- ly lower than those of the untreated side throughout study period. Sensitive Scale-10 was significantly improved after treatment. Conclusion: The application of UCB-MSC-CM resulted in improved skin barrier function and reduced inf lammatory responsiveness, which could provide beneficial effect on sensi- tive skin.
Abstract
Background: The exact definition of sensitive skin is not established yet. Since its high prevalence and significant inf luence on quality of life, it has become an important topic of research. Among various ingredients, conditioned media from umbilical cord blood-derived mesenchymal stem cells (UCB-MSC-CM) can be a promising source for the treatment of sensitive skin. Objective: We evaluated the efficacy and safety of UCB-MSC-CM on patients with sensitive skin. Methods: We designed a randomized, single blinded, prospective, split-face comparison study and enrolled thirty patients. All patients underwent nonablative fractional laser over the entire face before UCB-MSC-CM or normal saline was applied. Each facial area was randomly assigned to undergo treatment with either UCB-MSC-CM or normal saline. We performed three sessions at two-week intervals, and final results were assessed on six weeks after the last session. As an outcome measure, we evaluated a five-point global assessment scale, transepidermal water loss (TEWL), erythema index (EI) and Sensitive Scale-10. Twen- ty seven subjects were included in final analysis. Results: The treated side exhibited greater improvement compared to the untreated side based on a five-point global assessment scale. TEWL, EI of the treated side were significant- ly lower than those of the untreated side throughout study period. Sensitive Scale-10 was significantly improved after treatment. Conclusion: The application of UCB-MSC-CM resulted in improved skin barrier function and reduced inf lammatory responsiveness, which could provide beneficial effect on sensi- tive skin.
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