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비만이 아닌 남성에서 Framingham 위험점수와 심박동수 변이와의 관계

The Relationship of Framingham Risk Score and Heart Rate Variability in Non-obese Males

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키워드

주제분류가정의학

초록

연구배경: 고혈압, 흡연, 당뇨, 비만 등의 심혈관계 위험인자가 심박동수 변이 감소와 관련이 있음이 보고되었다. 이에 본 연구에서는 특히 비만이 아닌 남성에서 Framingham 심혈관 위험점수에 따른 각 군과 심박동수 변이와의 관계를 알아보고자 하였다. 방법: 2004년 6월부터 2004년 8월까지 일개 대학병원 건강검진센터를 방문한 수진자 중 비만이 아닌 남성 총 323명을 대상으로 하였다. Framingham 심혈관 위험점수에 따라 세 군으로 분류하였으며, Mean Heart Rate (MHR), Standard Deviation of NN interval (SDNN), The Square Root of the Mean Squared Differences of successive NN intervals (RMSSD), Total Power (TP), Very Low Frequency (VLF), Low Frequency (LF), High Frequency (HF), LF/HF ratio를 측정하여 세 군에서의 심박동수 변이 차이를 비교하였다. 결과: Framingham 위험점수와 연령은 유의한 관련성이 있었다. 위험점수가 높은 군에서 SDNN (P<0.001), RMSSD (P=0.001), TP (P=0.008), LF (P=0.024), HF (P=0.003)이 유의하게 낮았다. 다중 회귀분석 결과 위험점수를 구성하는 항목 중 흡연과 총 콜레스테롤을 제외한 모든 항목이 심박동수 변이에 영향을 주었으며 그 외에 C-반응성 단백도 독립변수로 나타났다. 결론: 심혈관 위험도가 높은 군에서 교감신경과 부교감신경 모두 조절력이 낮은 것으로 관찰되었다.

Abstract

The Relationship of Framingham Risk Score and Heart Rate Variability in Non-obese MalesSeung-Jun Lee, M.D., Young-Sung Suh, M.D., Dae-Hyun Kim, M.D.

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