The Correlation between the Triglyceride to High Density Lipoprotein Cholesterol Ratio and Computed Tomography- Measured Visceral Fat and Cardiovascular Disease Risk Factors in Local Adult Male Subjects
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Background: We studied the association between the triglyceride to high-density lipoprotein cholesterol ratio and computed tomography-measured visceral fat as well as cardiovascular risk factors among Korean male adults. Methods: We measured triglycerides, high density lipoprotein cholesterol, body mass, waist circumference, fasting plasma glucose, hemoglobin A1c, systolic blood pressure, diastolic blood pressure, visceral fat, and subcutaneous fat among 372 Korean men. The visceral fat and subcutaneous fat areas were measured by computed tomography using a single computed tomography slice at the L4-5 lumbar level. We analyzed the association between the triglyceride to high density lipoprotein cholesterol ratio and visceral fat as well as cardiovascular risk factors. Results: A positive correlation was found between the triglyceride to high density lipoprotein cholesterol ratio and variables such as body mass index, waist circumference, fasting plasma glucose, hemoglobin A1c, visceral fat, and the visceral-subcutaneous fat ratio. However, there was no significant correlation between the triglyceride to high density lipoprotein cholesterol ratio and subcutaneous fat or blood pressure. Multiple logistic regression analyses revealed significant associations between a triglyceride to high density lipoprotein cholesterol ratio ≥3 and diabetes, a body mass index ≥25 kg/m2, a waist circumference ≥90 cm, and a visceral fat area ≥100 cm2. The triglyceride to high density lipoprotein cholesterol ratio was not significantly associated with hypertension. Conclusion: There were significant associations between the triglyceride to high density lipoprotein cholesterol ratio and body mass, waist circumference, diabetes, and visceral fat among a clinical sample of Korean men. In the clinical setting, the triglyceride to high density lipoprotein cholesterol ratio may be a simple and useful indicator for visceral obesity and cardiovascular disease.
Abstract
Background: We studied the association between the triglyceride to high-density lipoprotein cholesterol ratio and computed tomography-measured visceral fat as well as cardiovascular risk factors among Korean male adults. Methods: We measured triglycerides, high density lipoprotein cholesterol, body mass, waist circumference, fasting plasma glucose, hemoglobin A1c, systolic blood pressure, diastolic blood pressure, visceral fat, and subcutaneous fat among 372 Korean men. The visceral fat and subcutaneous fat areas were measured by computed tomography using a single computed tomography slice at the L4-5 lumbar level. We analyzed the association between the triglyceride to high density lipoprotein cholesterol ratio and visceral fat as well as cardiovascular risk factors. Results: A positive correlation was found between the triglyceride to high density lipoprotein cholesterol ratio and variables such as body mass index, waist circumference, fasting plasma glucose, hemoglobin A1c, visceral fat, and the visceral-subcutaneous fat ratio. However, there was no significant correlation between the triglyceride to high density lipoprotein cholesterol ratio and subcutaneous fat or blood pressure. Multiple logistic regression analyses revealed significant associations between a triglyceride to high density lipoprotein cholesterol ratio ≥3 and diabetes, a body mass index ≥25 kg/m2, a waist circumference ≥90 cm, and a visceral fat area ≥100 cm2. The triglyceride to high density lipoprotein cholesterol ratio was not significantly associated with hypertension. Conclusion: There were significant associations between the triglyceride to high density lipoprotein cholesterol ratio and body mass, waist circumference, diabetes, and visceral fat among a clinical sample of Korean men. In the clinical setting, the triglyceride to high density lipoprotein cholesterol ratio may be a simple and useful indicator for visceral obesity and cardiovascular disease.
참고문헌 (30)
- "Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)", JAMA, 269, pp.3015~3023 (1993)
- Eliasson B, "Clinical usefulness of different lipid measures for prediction of coronary heart disease in type 2 diabetes: a report from the Swedish National Diabetes Register", Diabetes Care, 34, pp.2095~2100 (2011)
- Kimm H, "Associations between lipid measures and metabolic syndrome, insulin resistance and adiponectin: usefulness of lipid ratios in Korean men and women", Circ J, 74, pp.931~937 (2010)
- Kim SW, "Non-HDL-cholesterol", HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B, Int J Cardiol, pp.2013, 168[DOI]
- Dobiasova M, "The plasma parameter log (TG", HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)), 2001, pp.34, 583~588
- Jeppesen J, "Relation of high TGlow HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease: an 8-year follow-up in the Copenhagen Male Study", Arterioscler Thromb Vasc Biol, 17, pp.1114~1120 (1997)
- Vega GL, "Triglycerideto-high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men", J Investig Med, 62, pp.345~349 (2014)
- Gasevic D, "Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a crosssectional study", Lipids Health Dis, 13, pp.159~ (2014)
- Korean Society for the Study of Obesity, "Clinical obesity" (1995), Medical Book Publisher
- Park HS, "Visceral fat accumulation according to sex & age, and in relation to cardiovascular risk factors in Korean obese men & women", Korean J Obes, 7, pp.342~354 (1998)
- Tokunaga K, "A novel technique for the determination of body fat by computed tomography", Int J Obes, 7, pp.437~445 (1983)
- Despres JP, "Effects of diet and physical activity on adiposity and body fat distribution: implications for the prevention of cardiovascular disease", Nutr Res Rev, 6, pp.137~159 (1993)
- Fujioka S, "Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity", Metabolism, 36, pp.54~59 (1987)
- 이유현, "대사증후군과 인슐린저항성 평가를 위한 시상복부 직경의 유용성", Korean Journal of Family Medicine, 32(1), pp.46~55 (2011), 대한가정의학회
- Ribeiro-Filho FF, "Twohour insulin determination improves the ability of abdominal fat measurement to identify risk for the metabolic syndrome", Diabetes Care, 26, pp.1725~1730 (2003)
- Pascot A, "Contribution of visceral obesity to the deterioration of the metabolic risk profile in men with impaired glucose tolerance", Diabetologia, 43, pp.1126~1135 (2000)
- Kim JS, "The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance (HOMA-IR) in the general Korean population: based on the National Health and Nutrition Examination Survey in 2007-2009", Diabetes Res Clin Pract, 97, pp.132~138 (2012)
- Ozkaya I, "Body mass index and waist circumference affect lipid parameters negatively in Turkish women", Am J Public Health Res, 2, pp.226~231 (2014)
- Brenner DR, "Comparison of body mass index and waist circumference as predictors of cardiometabolic health in a population of young Canadian adults", Diabetol Metab Syndr, 2, pp.28~ (2010)
- Olson K, "The triglyceride to HDL ratio and its relationship to insulin resistance in pre- and postpubertal children:observation from the Wausau SCHOOL project", Cholesterol, 2012, pp.794252~ (2012)
- Kim-Dorner SJ, "Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance?", Metabolism, 59, pp.299~304 (2010)
- Sumner AE, "Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans", Arch Intern Med, 165, pp.1395~1400 (2005)
- He S, "Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population", Metabolism, 61, pp.30~36 (2012)
- Onat A, ""Atherogenic index of plasma” (log10triglyceride", high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events, 2010, pp.4, 89~98
- Halperin RO, "Dyslipidemia and the risk of incident hypertension in men", Hypertension, 47, pp.45~50 (2006)
- Tohidi M, "Triglycerides and triglycerides to high-density lipoprotein cholesterol ratio are strong predictors of incident hypertension in Middle Eastern women", J Hum Hypertens, 26, pp.525~532 (2012)
- Eeg-Olofsson K, "The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: an observational study from the Swedish National Diabetes Register (NDR)", Diabetes Res Clin Pract, 106, pp.136~144 (2014)
- Oh SW, "Cut-off point of BMI and obesity-related comorbidities and mortality in middle-aged Koreans", Obes Res, 12, pp.2031~2040 (2004)
- International Association for the Study of Obesity, "World Health Organization Western Pacific Region. The Asia-Pacific perspective: redefining obesity and its treatment" (1998), World Health Organization
- Li C, "Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race", ethnicity?, 2008, pp.7, 4~