Non-fasting triglyceride levels in the Korean population with and without ischemic heart disease and cerebrovascular disease
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Background/Aims: Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans. Methods: We conducted an analysis of patients aged ≥ 30 years from the nationwide survey database. Fasting TG was defined as a measurement taken ≥ 12 hours since the last meal. Non-fasting TG was categorized by fasting duration of 0 to 3, 4 to 7, and 8 to 11 hours. Results: In subjects without history of IHD/CVA, diabetes, or lipid-lowering medication, the TG level was significantly elevated for 7 hours in men compared to fasting TG levels (p = 0.011); the mean TG levels were 154.9 mg/dL (standard error [SE], 13.0), 177.0 mg/dL (SE, 12.1), 148.8 mg/dL (SE, 2.8), and 141.5 mg/dL (SE, 1.4) for 0 to 3, 4 to 7, 8 to 11, and ≥12 hours’ fasting, respectively. In women, there was no difference in TG level according to fasting duration after adjustment for confounders. In men without diabetes, the TG level from 4 to 7 hours’ fasting showed a significant difference between subjects with or without IHD/CVA even after adjustments for age, body mass index, lipid medication, exercise, and dietary factors (215.1 mg/dL vs. 177.3 mg/dL, p < 0.001). Conclusions: In men, non-fasting TG levels from 4 to 7 hours’ fasting were significantly associated with IHD/CVA, and were superior to fasting TG levels level in the significant association with the history of IHD or CVA.
Abstract
Background/Aims: Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans. Methods: We conducted an analysis of patients aged ≥ 30 years from the nationwide survey database. Fasting TG was defined as a measurement taken ≥ 12 hours since the last meal. Non-fasting TG was categorized by fasting duration of 0 to 3, 4 to 7, and 8 to 11 hours. Results: In subjects without history of IHD/CVA, diabetes, or lipid-lowering medication, the TG level was significantly elevated for 7 hours in men compared to fasting TG levels (p = 0.011); the mean TG levels were 154.9 mg/dL (standard error [SE], 13.0), 177.0 mg/dL (SE, 12.1), 148.8 mg/dL (SE, 2.8), and 141.5 mg/dL (SE, 1.4) for 0 to 3, 4 to 7, 8 to 11, and ≥12 hours’ fasting, respectively. In women, there was no difference in TG level according to fasting duration after adjustment for confounders. In men without diabetes, the TG level from 4 to 7 hours’ fasting showed a significant difference between subjects with or without IHD/CVA even after adjustments for age, body mass index, lipid medication, exercise, and dietary factors (215.1 mg/dL vs. 177.3 mg/dL, p < 0.001). Conclusions: In men, non-fasting TG levels from 4 to 7 hours’ fasting were significantly associated with IHD/CVA, and were superior to fasting TG levels level in the significant association with the history of IHD or CVA.
참고문헌 (36)
- Sarwar N, "Triglycerides and the risk of coronary heart disease : 10, 158 incident cases among 262, 525 participants in 29 Western prospective studies", Circulation, 115, pp.450~458 (2007)
- Tirosh A, "Changes in triglyceride levels and risk for coronary heart disease in young men", Ann Intern Med, 147, pp.377~385 (2007)
- Johansson S, "High lipid levels and coronary disease in women in Goteborg : outcome and secular trends : a prospective 19 year follow-up in the BEDA*study", Eur Heart J, 24, pp.704~716 (2003)
- ACCORD Study Group, "Effects of combination lipid therapy in type 2 diabetes mellitus", N Engl J Med, 362, pp.1563~1574 (2010)
- Scott R, "Effects of fenofibrate treatment on cardiovascular disease risk in 9, 795 individuals with type 2 diabetes and various components of the metabolic syndrome : the Fenofibrate Intervention and Event Lowering in Diabetes(FIELD)study", Diabetes Care, 32, pp.493~498 (2009)
- Bansal S, "Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women", JAMA, 298, pp.309~316 (2007)
- Langsted A, "Fasting and nonfasting lipid levels : influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction", Circulation, 118, pp.2047~2056 (2008)
- Cohn JS, "Plasma apolipoprotein changes in the triglyceride-rich lipoprotein fraction of human subjects fed a fatrich meal", J Lipid Res, 29, pp.925~936 (1988)
- Bower JF, "Ethnic differences in postprandial triglyceride response to a fatty meal and lipoprotein lipase in lean and obese African American and Caucasian women", Metabolism, 51, pp.211~217 (2002)
- Jacobson TA, "Hypertriglyceridemia and cardiovascular risk reduction", Clin Ther, 29, pp.763~777 (2007)
- American Diabetes Association, "2. Classification and diagnosis of diabetes", Diabetes Care, (38 Suppl), pp.S8~S16 (2015)
- Chalasani N, "The diagnosis and management of non-alcoholic fatty liver disease : practice guideline by the American Gastroenterological Association, American Association for the study of Liver Diseases, and American College of Gastroenterology", Gastroenterology, 142, pp.1592~1609 (2012)
- Van de Wiel A, "The effect of alcohol on postprandial and fasting triglycerides", Int J Vasc Med, 2012, pp.862504~ (2012)
- Langsted A, "Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes : 58 434 individuals from the Copenhagen General Population study", Clin Chem, 57, pp.482~489 (2011)
- Karlson BW, "A VOYAGER meta-analysis of the impact of statin therapy on low-density lipoprotein cholesterol and triglyceride levels in patients with hypertriglyceridemia", Am J Cardiol, 117, pp.1444~1448 (2016)
- Nordestgaard BG, "Fasting is not routinely required for determination of a lipid profile : clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine", Eur Heart J, 37, pp.1944~1958 (2016)
- Zilversmit DB, "Atherogenesis : a postprandial phenomenon", Circulation, 60, pp.473~485 (1979)
- Varbo A, "Remnant cholesterol as a causal risk factor for ischemic heart disease", J Am Coll Cardiol, 61, pp.427~436 (2013)
- de Graaf J, "Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects", Arterioscler Thromb, 11, pp.298~306 (1991)
- "Hypertriglyceridaemia and vascular risk: report of a meeting of physicians and scientists, University College London Medical School", Lancet, 342, pp.781~787 (1993)
- Cohn JS, "Postprandial plasma lipoprotein changes in human subjects of different ages", J Lipid Res, 29, pp.469~479 (1988)
- Sarac I, "Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men", J Clin Endocrinol Metab, 97, pp.2475~2481 (2012)
- Moon JH, "Optimal high-density lipoprotein cholesterol cutoff for predicting cardiovascular disease : comparison of the Korean and US National Health and Nutrition Examination Surveys", J Clin Lipidol, 9, pp.334~342 (2015)
- Chandak GR, "Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans", BMC Med Genet, 7, pp.76~ (2006)
- Chhabra S, "Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians", BMC Genet, 3, pp.9~ (2002)
- Hu EA, "White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review", BMJ, 344, pp.e1454~ (2012)
- Lee MJ, "The unique aspects of the nutrition transition in South Korea : the retention of healthful elements in their traditional diet", Public Health Nutr, 5, pp.197~203 (2002)
- Harbis A, "Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects", Am J Clin Nutr, 80, pp.896~902 (2004)
- Mamo JC, "A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet", Eur J Clin Nutr, 59, pp.1142~1148 (2005)
- Iso H, "Serum triglycerides and risk of coronary heart disease among Japanese men and women", Am J Epidemiol, 153, pp.490~499 (2001)
- Acartürk E, "Relation between age and gender differences in plasma triglyceride concentrations and coronary artery disease in Southern Turkey", Clin Chim Acta, 339, pp.123~128 (2004)
- Hokanson JE, "Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level : a meta-analysis of population-based prospective studies", J Cardiovasc Risk, 3, pp.213~219 (1996)
- Karim MN, "Pattern and predictors of dyslipidemia in patients with type 2 diabetes mellitus", Diabetes Metab Syndr, 7, pp.95~100 (2013)
- Mero N, "Postprandial metabolism of apolipoprotein B-48-and B-100-containing particles in type 2 diabetes mellitus : relations to angiographically verified severity of coronary artery disease", Atherosclerosis, 150, pp.167~177 (2000)
- Syvanne M, "Abnormal metabolism of postprandial lipoproteins in patients with non-insulin-dependent diabetes mellitus is not related to coronary artery disease", J Lipid Res, 35, pp.15~26 (1994)
- Haffner SM, "Lipoprotein disorders associated with type 2 diabetes mellitus and insulin resistance", Am J Cardiol, 90, pp.55i~61i (2002)