Relationship Between Alcohol Consumption and Prostatic Hyperplasia According to Facial Flushing After Drinking in Korean Men
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Background: The purpose of this study was to examine whether facial flushing after drinking influences the rela-tionship between alcohol consumption and prostatic hyperplasia among Korean men.Methods: The subjects were 957 Korean men (180 non-drinkers, 389 with drinking-related facial flushing, 388 without facial flushing) in the 40–69 age group, who underwent prostate ultrasound at the health promotion center of Chungnam National University Hospital between 2008 and 2014. Alcohol consumption and alcohol-related fa-cial flushing were assessed through a questionnaire. In terms of the amount consumed, 14 g of alcohol was consid-ered a standard drink. With the non-drinker group as reference, logistic regression was used to analyze the relation-ship between weekly alcohol intake and prostatic hyperplasia in the flushing and non-flushing groups, with adjust-ment for confounding factors such as age, body mass index, smoking, and exercise patterns.Results: Individuals aged 50–59 years who experienced drinking-related facial flushing had a significantly lower risk of prostatic hyperplasia than the non-drinker group, depending on alcohol consumption: ≤4 standard drinks (adjusted odds ratio [OR], 0.38; 95% confidence interval [CI], 0.16 to 0.86); >4 ≤8 standard drinks (OR, 0.35; 95% CI, 0.13 to 0.95); >8 standard drinks (OR, 0.33; 95% CI, 0.13 to 0.84). However, no significant relationship was observed between the number of drinks consumed and the risk of prostate hyperplasia in the non-flushing group.Conclusion: The risk of prostatic hyperplasia appears to be reduced by alcohol consumption among Korean men aged 50–59 years who exhibit drinking-related facial flushing.
Abstract
Background: The purpose of this study was to examine whether facial flushing after drinking influences the rela-tionship between alcohol consumption and prostatic hyperplasia among Korean men.Methods: The subjects were 957 Korean men (180 non-drinkers, 389 with drinking-related facial flushing, 388 without facial flushing) in the 40–69 age group, who underwent prostate ultrasound at the health promotion center of Chungnam National University Hospital between 2008 and 2014. Alcohol consumption and alcohol-related fa-cial flushing were assessed through a questionnaire. In terms of the amount consumed, 14 g of alcohol was consid-ered a standard drink. With the non-drinker group as reference, logistic regression was used to analyze the relation-ship between weekly alcohol intake and prostatic hyperplasia in the flushing and non-flushing groups, with adjust-ment for confounding factors such as age, body mass index, smoking, and exercise patterns.Results: Individuals aged 50–59 years who experienced drinking-related facial flushing had a significantly lower risk of prostatic hyperplasia than the non-drinker group, depending on alcohol consumption: ≤4 standard drinks (adjusted odds ratio [OR], 0.38; 95% confidence interval [CI], 0.16 to 0.86); >4 ≤8 standard drinks (OR, 0.35; 95% CI, 0.13 to 0.95); >8 standard drinks (OR, 0.33; 95% CI, 0.13 to 0.84). However, no significant relationship was observed between the number of drinks consumed and the risk of prostate hyperplasia in the non-flushing group.Conclusion: The risk of prostatic hyperplasia appears to be reduced by alcohol consumption among Korean men aged 50–59 years who exhibit drinking-related facial flushing.
참고문헌 (26)
- Berry SJ, "The development of human benign prostatic hyperplasia with age", J Urol, 132, pp.474~479 (1984)
- Lee E, "Prevalence of lower urinary tract symptoms in Korean men in a community-based study", Eur Urol, 33, pp.17~21 (1998)
- Lee H, "Correlation between age, prostatic volume and voiding symptoms in randomly selected Korean over age 60", Korean J Urol, 35, pp.1208~1213 (1994)
- Ozden C, "The correlation between metabolic syndrome and prostatic growth in patients with benign prostatic hyperplasia", Eur Urol, 51, pp.199~203 (2007)
- 김재헌, "전립선비대증에서 대사증후군 관련요인 분석", Investigative and Clinical Urology, 46(10), pp.1046~1050 (2005), 대한비뇨기과학회
- Platz EA, "Alcohol consumption, cigarette smoking, and risk of benign prostatic hyperplasia", Am J Epidemiol, 149, pp.106~115 (1999)
- Lee E, "A high-risk group for prostatism : a population-based epidemiological study in Korea", Br J Urol, 79, pp.736~741 (1997)
- Mendelson JH, "Effects of acute alcohol intake on pituitary-gonadal hormones in normal human males", J Pharmacol Exp Ther, 202, pp.676~682 (1977)
- Caine M, "The present role of alpha-adrenergic blockers in the treatment of benign prostatic hypertrophy", J Urol, 136, pp.1~4 (1986)
- Ohta S, "Mitochondrial ALDH2 deficiency as an oxidative stress", Ann N Y Acad Sci, 1011, pp.36~44 (2004)
- Wang Y, "Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population", J Hum Hypertens, 27, pp.181~186 (2013)
- 석호식, "Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population", International Neurourology Journal, 17(4), pp.168~173 (2013), 대한배뇨장애요실금학회
- Guo R, "Alcohol and acetaldehyde in public health : from marvel to menace", Int J Environ Res Public Health, 7, pp.1285~1301 (2010)
- Garraway WM, "High prevalence of benign prostatic hypertrophy in the community", Lancet, 338, pp.469~471 (1991)
- Bruchovsky N, "Hormonal effects on cell proliferation in rat prostate", Vitam Horm, 33, pp.61~102 (1975)
- Joseph MA, "Risk factors for lower urinary tract symptoms in a population-based sample of African-American men", Am J Epidemiol, 157, pp.906~914 (2003)
- McConnell JD, "The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia", N Engl J Med, 349, pp.2387~2398 (2003)
- Thompson IM, "The influence of finasteride on the development of prostate cancer", N Engl J Med, 349, pp.215~224 (2003)
- Chyou PH, "A prospective study of alcohol, diet, and other lifestyle factors in relation to obstructive uropathy", Prostate, 22, pp.253~264 (1993)
- Crispo A, "Alcohol and the risk of prostate cancer and benign prostatic hyperplasia", Urology, 64, pp.717~722 (2004)
- Ida Y, "Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males", Drug Alcohol Depend, 31, pp.57~64 (1992)
- Gordon GG, "Effect of alcohol(ethanol)administration on sex-hormone metabolism in normal men", N Engl J Med, 295, pp.793~797 (1976)
- Green GR, "Mechanism of hypogonadism in cirrhotic males", Gut, 18, pp.843~853 (1977)
- Frea B, "Correlation between liver cirrhosis and benign prostatic hyperplasia : a morphological study", Urol Res, 15, pp.311~314 (1987)
- McKeehan WL, "Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture", Cancer Res, 44, pp.1998~2010 (1984)
- Merendino RA, "Malondialdehyde in benign prostate hypertrophy: a useful marker?", Mediators Inflamm, 12, pp.127~128 (2003)