Relationship between Alcohol Consumption and Testosterone Deficiency according to Facial Flushes among Middle-Aged and Older Korean Men
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Background: This study examined the relationship between alcohol consumption and total testosterone deficiency based on facial flushing among Korean men.Methods: A total of 314 men were included in this study and divided into non-drinkers (n=78) and drinkers (n=236). Drinkers were also divided into flushers (n=96) and non-flushers (n=140). Flushers and non-flushers were separated into two groups based on the amount of alcohol consumed: moderate drinkers (≤8 standard drinks per week) and heavy drinkers (>8 standard drinks per week). Total testosterone <3.5 ng/mL was defined as testosterone deficiency.Results: The risk of testosterone deficiency was significantly higher in heavy drinkers who flushed than in non-drinkers (odds ratio, 4.37; 95% confidence interval, 1.20–15.88; P=0.025). However, no significant difference was ob-served in the risk of testosterone deficiency in non-flushers, regardless of the amount of alcohol consumed.Conclusion: This study suggests that the risk of testosterone deficiency increases in heavy drinkers (>8 drinks per week) who flush compared to that in non-drinkers.
Abstract
Background: This study examined the relationship between alcohol consumption and total testosterone deficiency based on facial flushing among Korean men.Methods: A total of 314 men were included in this study and divided into non-drinkers (n=78) and drinkers (n=236). Drinkers were also divided into flushers (n=96) and non-flushers (n=140). Flushers and non-flushers were separated into two groups based on the amount of alcohol consumed: moderate drinkers (≤8 standard drinks per week) and heavy drinkers (>8 standard drinks per week). Total testosterone <3.5 ng/mL was defined as testosterone deficiency.Results: The risk of testosterone deficiency was significantly higher in heavy drinkers who flushed than in non-drinkers (odds ratio, 4.37; 95% confidence interval, 1.20–15.88; P=0.025). However, no significant difference was ob-served in the risk of testosterone deficiency in non-flushers, regardless of the amount of alcohol consumed.Conclusion: This study suggests that the risk of testosterone deficiency increases in heavy drinkers (>8 drinks per week) who flush compared to that in non-drinkers.
참고문헌 (25)
- Wu FC, "Identification of late-onset hypogonadism in middle-aged and elderly men", N Engl J Med, 363, pp.123~135 (2010)
- Bhasin S, "Testosterone therapy in men with hypogonadism : an endocrine society clinical practice guideline", J Clin Endocrinol Metab, 103, pp.1715~1744 (2018)
- Duca Y, "Substance abuse and male hypogonadism", J Clin Med, 8, pp.732~ (2019)
- Anderson RA, "Hormonal imbalance and alterations in testicular morphology induced by chronic ingestion of ethanol", Biochem Pharmacol, 29, pp.1409~1419 (1980)
- Van Thiel DH, "Ethanol, a Leydig cell toxin: evidence obtained in vivo and in vitro", Pharmacol Biochem Behav, 18(Suppl 1), pp.317~323 (1983)
- Ida Y, "Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males", Drug Alcohol Depend, 31, pp.57~64 (1992)
- Muthusami KR, "Effect of chronic alcoholism on male fertility hormones and semen quality", Fertil Steril, 84, pp.919~924 (2005)
- Maneesh M, "Alcohol abuseduration dependent decrease in plasma testosterone and antioxidants in males", Indian J Physiol Pharmacol, 50, pp.291~296 (2006)
- Svartberg J, "The associations of age, lifestyle factors and chronic disease with testosterone in men : the Tromso Study", Eur J Endocrinol, 149, pp.145~152 (2003)
- Watts EL, "Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12, 300men", PLoS One, 12, pp.e0187741~ (2017)
- Jensen TK, "Alcohol and male reproductive health : a cross-sectional study of 8344healthy men from Europe and the USA", Hum Reprod, 29, pp.1801~1809 (2014)
- Hansen ML, "Does last week’s alcohol intake affect semen quality or reproductive hormones? : a cross-sectional study among healthy young Danish men", Reprod Toxicol, 34, pp.457~462 (2012)
- WolffPH, "Ethnic differences in alcohol sensitivity", Science, 175, pp.449~450 (1972)
- Agarwal DP, "Racial differences in biological sensitivity to ethanol : the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes", Alcohol Clin Exp Res, 5, pp.12~16 (1981)
- Jung JG, "Hypertension associated with alcohol consumption based on the facial flushing reaction to drinking", Alcohol Clin Exp Res, 38, pp.1020~1025 (2014)
- Jung JG, "Relationships among alcohol consumption, facial flushing response, and metabolic syndrome in healthy men", Ann Epidemiol, 22, pp.480~486 (2012)
- Yu Ri Seo, "Association between Alcohol Consumption and Metabolic Syndrome Determined by Facial Flushing in Korean Women", Korean Journal of Family Medicine, 42(1), pp.24~30 (2021), 대한가정의학회[DOI]
- Jung JG, "The role of the flushing response in the relationship between alcohol consumption and insulin resistance", Alcohol Clin Exp Res, 34, pp.1699~1704 (2010)
- Ji-Han Kim, "Influence of Facial Flushing on Pre- or Type 2 Diabetes Risk according to Alcohol Consumption in Korean Male", Korean Journal of Family Medicine, 41(3), pp.153~160 (2020), 대한가정의학회[DOI]
- Sami Lee, "Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing", Korean Journal of Family Medicine, 40(4), pp.204~211 (2019), 대한가정의학회[DOI]
- Jana K, "Ethanol induces mouse spermatogenic cell apoptosis in vivo through over-expression of Fas", Fas-L, p53, and caspase-3 along with cytochrome c translocation and glutathione depletion, 2010, pp.77, 820~833
- Yokoyama A, "Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk", Cancer Epidemiol Biomarkers Prev, 6, pp.1105~1107 (1997)
- Shin CM, "Validation of alcohol flushing questionnaires in determining inactive aldehyde dehydrogenase-2and its clinical implication in alcohol-related diseases", Alcohol Clin Exp Res, 42, pp.387~396 (2018)
- Kim J, "Relationship between alcohol consumption and rheumatoid factor(RF)with alcohol-induced facial flushing response", Alcohol, 84, pp.43~48 (2020)
- Sami Lee, "Relationship between Alcohol Consumption and Ocular Pressure according to Facial Flushing in Korean Men with Obesity", Korean Journal of Family Medicine, 40(6), pp.399~405 (2019), 대한가정의학회[DOI]
