한국 성인 남성에서 Osteoporosis Self-Assessment Tool의 유용성 평가
Evaluation of Osteoporosis Self-Assessment Tool Usefulness as a Screening Test for Osteoporosis in Korean Men
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연구배경: 한국 성인 남성에서 골다공증 고위험군 선별을 위 한 Osteoporosis Self-assessment Tool (OST)의 유용성을 알아보 고자 한다. 방법: 2005년 8월에서 2008년 8월까지 일개 대학병원의 50세 이상 건강검진 수검자를 대상으로 체중과 나이를 기초로 계 산한 OST risk index와 DXA로 측정한 골밀도 수치를 비교 분석 하였다. 결과: 최종 연구 대상자는 276명이었다. 평균나이는 59.7± 6.69세였고, 평균 키와 몸무게는 167.6±6.14 cm, 67.5±8.93 kg이 었다. DXA 측정 결과 4.7%가 골다공증, 46.4%가 골감소증으 로 진단되었다. OST risk index는 -4에서 7까지 분포했다. 전체 대상군에서 risk index 0을 기준으로 했을 때 골다공증에 대한 민감도는 85%, 특이도 62%였으며 ROC 곡선을 그렸을 때 area under the curve (AUC)는 0.77이었다. 골다공증의 주요 위험인 자인 연령, 흡연 여부에 따라 나누어 분석했을 때 AUC가 높아 지는 경향을 보였다. 결론: OST는 한국 성인 남성에서도 골다공증 위험을 선별하 기 위해 유용하게 사용할 수 있는 간편한 방법이다.
Abstract
Background: This study was done to determine whether the Osteoporosis Self-assessment Tool (OST) can predict central bone mineral density in Korean men above 50 years, as defi ned by dual energy X-ray absorptionmetry (DXA). Methods: We applied the OST index to Korean men aged over 50 in Health Promotion Center of Konkuk University Hospital from September 2005 to September 2008. The calculated OST risk index was based on weight and age, truncated to an integer. Results: The study population was 276 men. The mean age, height and weight of the men were 59.7 ± 6.69 years, 167.6 ± 6.14 cm and 67.5 ± 8.93 kg respectively. By DXA, 4.7% of the men had a T score of -2.5 or less, and 46.4% had a T score of -2 or less at the spine, total hip, or femoral neck. The OST index ranged from -4 to 7. Using a cutoff score of 0, we predicted osteoporosis with a sensitivity of 85% and a specifi city of 62%. The receiver operating characteristic curve showed an area under the curve of 0.77. When the subjects were analyzed by age and smoking status, the predictive value of the OST was maintained. Conclusion: The OST is a simple and useful method to predict osteoporosis in Korean men.
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