한국인의 나이와 성별, 지역에 따른 골밀도의 변화(2003～2004)
Age-, Gender- and Region- Related Changes in Bone Mineral Density of Korean Adult (2003～2004)
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목적: 골다공증의 유병률은 증가하고 있으나 우리의 골다공증 진단 기준이 없는 것이 현실이다. 이에 본 연구에서는 우리 골밀도 자료를 아이와 지역, 성별, 부위에 따라 분석하여 보았다. 방법: 2003～2004년에 시행한 골밀도 검사 50,208 예의 요추와 50,026 예의 대퇴골의 골밀도를 각 연령군으로 나누어서 후향적으로 분석하였다. 골밀도 검사는 DEXA-법을 이용하여 측정하였다. 결과: 여성 요추 골밀도는 35～44세 군에서 0.985 ±0.129 g/cm2로 가장 높았고 이후 감소하기 시작하여 폐경기에 골밀도의 감소가 가장 컸다. 남성에서는 25～34세의 골밀도(1.011±0.118 g/cm2)가 가장 높았다. 대퇴골의 골밀도는 여성의 경우 35～44세에서 0.864±0.114 g/cm2로, 남성의 경우 25～34세에서 골밀도가 0.960±0.133 g/cm2로 가장 높았다. 지역에 따라서는 서울 이외의 지역의 peak BMD가 높았으나 오히려 골밀도의 감소 속도는 빨랐다. 결론: 우리나라인구 집단에서의 골밀도는 남성에서는 30살 전후로 여성에서는 40세 전후로 최대 골밀도에 도달하는 것을 관찰할 수 있었으며 서울보다 서울 이외의 지역에서의 골밀도의 감소가 심하였다.
Abstract
Objectives: The incidence of osteoporosis in Korea has increased rapidly, however there are no reference values for bone mineral density (BMD) in the Korean population. We analyzed the BMD data of Koreans based on age, gender, and region. Methods: We reviewed BMD data (L-spine, n=50,208; femur, n=50,026) that was obtained in hospitals in Korea between 2003 and 2004. BMD was measured using QDR 4000 and QDR 4500 systems (Hologic, USA). Results: The mean lumbar BMD in females in the 35-44-year-age group was 985±129 mg/cm2 and had the highest values compared to other age groups. The BMD decreased rapidly in the menopause. The mean lumbar BMD in males peaked in the 25-34-year-age group. The mean BMD in females and males peaked in the 35-44-year-age group (864±114 mg/cm2) and 25-34-year-age group (960±133 mg/cm2), respectively. The mean lumbar BMD of urban residents was higher than the mean lumbar BMD rural residents after 45 years of age. Conclusion: In the Korean population, the peak BMD was achieved at approximately 30 and 40 years of age in males and females, respectively. There were differences in the mean BMD between urban and rural regions in the elderly age group.
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