외상후 스트레스 장애 동반 여부에 따른 정신분열병 환자의 임상증상과 치료효과의 비교: 1년간의 전향적 추적연구
Comorbidity of Posttraumatic Stress Disorder and Its Effect on Treatment Outcomes in Patients with Schizophrenia: One-Year Prospective Follow-Up Study
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Objectives:The aims of this study were to assess a) the prevalence of trauma and posttraumatic stress disorder (PTSD) in schizophrenic patients and b) the differences in symptomatology and outcome after 1 year treatment between those with and without PTSD. . Methods:Twenty eight schizophrenia and schizoaffective disorder patients completed the Positive and Negative Syndrome Scale (PANSS), the Life Stressor Checklist-Revised (LSCL-R), C the linician-Administered PTSD Scale (CAPS), the Dissociative Experiences Scale (DES), the Hamilton Psychiatry Rating Scale for Depression (HAM-D), and the Rosenberg Self-Esteem Scale (RSE). Results:Twenty six patients (92.9%) had at least one trauma in their life time. Eleven patients (39.3%) were diagnosed with PTSD. The PTSD group had significantly higher scores on HAM-D and DES but lower scores on RSE. The PTSD group also had significantly lower score in the baseline PANSS Negative score. Higher CAPS scores were significantly correlated with lower baseline PANSS Negative score and greater change after 1 year of PANSS Negative score. Conclusion:These results showed that the prevalences of trauma and PTSD are high in schizophrenic patients and suggested that PTSD and trauma-related symptoms affected the symptomatology and treatment outcome. More research is warranted to better understand the effects of PTSD in schizophrenic patients.
Abstract
Objectives:The aims of this study were to assess a) the prevalence of trauma and posttraumatic stress disorder (PTSD) in schizophrenic patients and b) the differences in symptomatology and outcome after 1 year treatment between those with and without PTSD. . Methods:Twenty eight schizophrenia and schizoaffective disorder patients completed the Positive and Negative Syndrome Scale (PANSS), the Life Stressor Checklist-Revised (LSCL-R), C the linician-Administered PTSD Scale (CAPS), the Dissociative Experiences Scale (DES), the Hamilton Psychiatry Rating Scale for Depression (HAM-D), and the Rosenberg Self-Esteem Scale (RSE). Results:Twenty six patients (92.9%) had at least one trauma in their life time. Eleven patients (39.3%) were diagnosed with PTSD. The PTSD group had significantly higher scores on HAM-D and DES but lower scores on RSE. The PTSD group also had significantly lower score in the baseline PANSS Negative score. Higher CAPS scores were significantly correlated with lower baseline PANSS Negative score and greater change after 1 year of PANSS Negative score. Conclusion:These results showed that the prevalences of trauma and PTSD are high in schizophrenic patients and suggested that PTSD and trauma-related symptoms affected the symptomatology and treatment outcome. More research is warranted to better understand the effects of PTSD in schizophrenic patients.
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