골절단을 이용한 급속 치아이동 후 치수 및 치주조직 변화
Tissue changes of pulp and periodontium on rapid tooth movement with osteotomy in dogs
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본 연구는 골절단을 이용한 치아-치조골 분절의 급속 치아이동 후 치수, 치주인대 및 치조골의 변화를 유성견에서 평가하고자 하였다. 하악 제4소구치의 근심, 원심, 치근단 부위에서 피질골을 절단하여 치아-골 분절을 형성하고 하악 제3소구치를 발거하면서 협측, 설측 부위의 피질골을 삭제하였다. 1주 휴지기 부여에 따라 휴지기군과 비휴지기군으로 나누어 치아의존형 견인장치로 6일 동안 견인하고 강화기를 거친 후 0주, 1주, 2주, 4주, 6주, 8주에 희생시켜 치수, 치주인대 및 치조골의 조직 변화를 임상적, 방사선적, 조직학적 및 면역화학적으로 평가하여 다음과 같은 결과를 얻었다. 1. 치아이동 양과 강화기 동안의 조직 치유 양상에서 휴지기 유무에 따른 차이는 없었다. 2. 견인측에서 골형성은 강화기 8주까지 계속되었는데 강화기 1-2주에 가장 활발하였으며 6-8주간의 변화는 적었다. 3. 비휴지기군의 강화기 1주에서 치조골 흡수 및 파골세포 출현, 염증세포 침윤이 가장 많았으며, 특징적으로 파상아세포가 압박측의 치주인대와 치수 내에 나타났다. 4. TGF-β는 치조골의 골기질 및 골모세포, 파골세포, 치수 내 파상아세포에서 강양성 발현을 보인 반면 치수, 백악모세포, 무세포성 백악질에서 경미한 양성 발현을 나타내는 부위 특이성이 있었다. 5. TGF-β는 견인측 치주인대의 치조골에 인접한 혈관 및 치주인대세포, 골모세포에서 강화기 초기 1-2주에 주로 발현되었으며 6주 이후에는 발현이 크게 감소하였다.
Abstract
The movement of tooth-bone segments by osteotomy can simultaneously shift tooth and surrounding alveolar bone in a relatively short period. The purpose of this study was to evaluate the tissue changes in pulp, periodontal ligament, and alveolar bone in rapid tooth-bone movement with osteotomy. The mandibular 3rd premolar of a dog was extracted and cortical bones of the buccal and lingual area were eliminated, and then cortical bones around the mesial and distal area of root, and below the root apex of the mandibular 4th premolar were osteotomized. After a one-week latency period, a tooth-borne distraction device was activated for 6 days. And pulp, periodontal ligament and alveolar bone were evaluated clinically, radiologically, histologically and immunohistochemically at 0, 1, 2, 4, 6, 8 weeks of the consolidation period and conclusions were reached as follows. 1. Latency period didn't affect total amount of tooth movement and healing process of tissue during consolidation period. 2. Bone formation continued through 8 weeks of consolidation in distracted side, with a high peak at 1-2 weeks, and the lowest at 6-8 weeks of consolidation. 3. At 1 week of consolidation, alveolar bone resorption, osteoclast appearance and inflammatory cell infiltration were the most active, and dentinoclasts characteristically appeared on the pulp and pressure side of the periodontal ligament. 4. The expression of TGF-β was area-specific, as it was strong-positive at bone matrix, osteoblast, osteoclast of alveolar bone, and dentinoclast inside pulp, but weak in pulp, cementoblast and acellular cementum. 5. The expression of TGF-β was generally observed at the initial 1-2 weeks of consolidation at vessels, periodontal ligament cells, and osteoblast near alveolar bone on the distraction side of the periodontal ligament, and was significantly decreased after 6 weeks of consolidation.
참고문헌 (40)
- "On the means of lengthening in the lower limb the muscles and tissues which are shortened through deformity", pp.4~9 (1994)
- "The tension-stress effect on the genesis and growth of tissues The influence of stability of fixation and soft-tissue preservation", pp.249~81
- "The tension-stress effect on the genesis and growth of tissues The influence of the rate and frequency of distraction", pp.263~85
- "Clinical application of the tension-stress effect for limb lengthening", pp.8~26
- "Mandibular lengthening by gradual distraction", pp.506~8
- "Lengthening of mandibular body by gradual surgical-orthodontic distraction"
- "Experimental tooth movement through regenerate alveolar bone:A pilot study", 116, pp.501~505 (1999)
- "Intraoral widening and lengthening of the mandible in baboons by distraction osteogenesis", 57, pp.548~562 (1999)
- "Strain-related bone remodeling in distraction osteogenesis of the mandible", 103, pp.800~807 (1999)
- "Evaluation of the consolidation period during osteodistraction using computed tomography", 116, pp.254~263 (1999)
- "Regenerate bone formation and remodeling during mandibular osteodistraction", 70, pp.99~111 (2000)
- "The histologic analysis of distraction osteogenesis of the mandible in rabbits", pp.152~9, Yonemara Y
- "Rapid canine retraction through distraction of the periodontal ligament", 114, pp.372~382 (1998)
- "Surgical operations on the alveolar ridge to correct occlusal abnormalities", pp.413 515~20 28
- "Surgical-orthodontic correction of adult malocclusions", pp.551~63
- "Treatment of an ankylosed central incisor by single-tooth dento-osseous osteotomy", 112, pp.496~501 (1997)
- "Surgical-orthodontic treatment of malpositioned cuspids", pp.847~51
- "Surgical-orthodontic treatment for overerupted maxillary molars", pp.350~1
- "Intrusion of overerupted molars by corticotomy and magnets", 120, pp.209~216 (2001)
- "Interobserver variability in radiographic interpretation of pediatric dental diseases: A pilot study", 62 (1996)
- "Reliability of radiographical interpretations", pp.71~5
- "Techniques for assessing alveolar bone mass changes in periodontal disease with emphasis on 125I-absorptiometry", pp.455~64
- "Comparison of film direct digital and tuned-aperture computed tomography images to identify the location of crestal defects around endosseous titanium implants", 81, pp.480~490 (1996)
- "A robust digital method for film contrast correction in subtraction radiography", pp.486~95
- "Recognizing invariant geometric structure in dental radiographs", pp.142~7
- "A comparison of two registration for digital subtraction radiography", pp.77~80
- "Study on histologic changes of periodontal membrane incident to experimental tooth movement", pp.149~78, Bull Tokyo Med Dent Univ 1970
- "Mandibular distraction osteogenesis:A comparison of distraction rates in the rabbit model", 26, pp.43~49 (1998)
- "Effect of distraction rate on biomechanical, mineralization, and histologic properties of an ovine mandible model", 105, pp.889~895 (2000)
- "Effects of latency and rate on bone formation in a porcine mandibular distraction model", 58, pp.507~513 (2000)
- "Effect of rhythm and level of distraction on muscle structure: An animal study", 384, pp.250~264 (2001)
- "The effect of magnitude and frequency of interfragmentary strain on the tissue response to distraction osteogenesis", 57, pp.1331~1339 (1999)
- "The callotasis method of limb lengthening", pp.137~45
- "Limb lengthening by callotasis for children and adolescents", pp.105~11
- "The role of latency in mandi bular osteodistraction", 26, pp.209~219 (1998)
- "The effect ofgradual distraction of the mandible on the sheep temporomandibular joint", 25, pp.152~156 (1996)
- "Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones", pp.2024~8
- "Human platelet-derived transforming growth factor-β stimulates parameters of bone growth in fetal rat calvariae", pp.2306~12
- "Type-β transforming growth factor in human platelets Release during platelet degranulation and action on vascular smooth muscle cells", pp.1217~23
- "TGF-β expression in fibropapillomas induced by Bovine Papillomavirus type I and in BPV-I transformed cells", pp.111~21
