Histopathologic investigation of the effects of prostaglandin E2 administered by different methods on tooth movement and bone metabolism
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: Th e aim of this study was to investigate and compare the in vivo effects of prostaglandin E2 (PGE2) administered by different methods on orthodontic tooth movement and bone metabolism macroscopically, histopatologically, and biochemically. Methods: Forty-five young adult New Zealand rabbits were randomly divided into 3 experimental groups (n = 10/group), 1 positive control group (n = 10), and 1 negative control group (n = 5). The experimental rabbits were fi tted with springs exerting 20-g reciprocal force on the maxillary incisors and PGE2 (10 μg/mL) was administered by the intravenous, submucosal, or intra ligamentous route aft er appliance insertion and on days 1, 3, 7, and 14 thereaft er. All rabbits were sacrifi ced on day 21 and their premaxillae were resected for histologic evaluation. Results: Tooth movement was observed in the experimental and positive control groups, but the intraligamentous PGE2 group had the highest values of all analyzed parameters, including serum calcium and phosphorus levels and osteoclastic and osteoblastic populations (p < 0.001). Conclusions:Sub mucosal and intraligamentous PGE2 administration significantly increases orthodontic tooth movement and bone metabolism, but the intraligamentous route seems to be more effective.
Abstract
Objective: Th e aim of this study was to investigate and compare the in vivo effects of prostaglandin E2 (PGE2) administered by different methods on orthodontic tooth movement and bone metabolism macroscopically, histopatologically, and biochemically. Methods: Forty-five young adult New Zealand rabbits were randomly divided into 3 experimental groups (n = 10/group), 1 positive control group (n = 10), and 1 negative control group (n = 5). The experimental rabbits were fi tted with springs exerting 20-g reciprocal force on the maxillary incisors and PGE2 (10 μg/mL) was administered by the intravenous, submucosal, or intra ligamentous route aft er appliance insertion and on days 1, 3, 7, and 14 thereaft er. All rabbits were sacrifi ced on day 21 and their premaxillae were resected for histologic evaluation. Results: Tooth movement was observed in the experimental and positive control groups, but the intraligamentous PGE2 group had the highest values of all analyzed parameters, including serum calcium and phosphorus levels and osteoclastic and osteoblastic populations (p < 0.001). Conclusions:Sub mucosal and intraligamentous PGE2 administration significantly increases orthodontic tooth movement and bone metabolism, but the intraligamentous route seems to be more effective.
참고문헌 (31)
- van de Velde JP, "Histologic reactions in gingival and alveolar tissues during tooth movement in rabbits", Eur J Orthod, 10, pp.296~308 (1988)
- Persson M, "A 100th anniversary: Sandstedt’s experiments on tissue changes during tooth movement", J Orthod, 32, pp.27~28 (2005)
- Baumrind S, "Rate changes in cell repli cation and protein synthesis in the periodontal liga ment incident to tooth movement", Am J Orthod, 57, pp.109~131 (1970)
- Lilja E, "Histochemistry of enzymes associated with tissue degradation incident to orthodontic tooth movement", Am J Orthod, 83, pp.62~75 (1983)
- Yamasaki K, "Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement", Am J Orthod, 85, pp.508~518 (1984)
- Yamasaki K, "The effect of prostaglandins on experimental tooth movement in monkeys (Macaca fuscata)", J Dent Res, 61, pp.1444~1446 (1982)
- Vandevska-Radunovic V, "Effect of experimental tooth movement on nerve fibres immunoreactive to calcitonin gene-related peptide, protein gene product 9.5, and blood vessel density and distribution in rats", Eur J Orthod, 19, pp.517~529 (1997)
- Davidovitch Z, "Neurotransmitters, cytokines, and the control of alveolar bone remodeling in orthodontics", Dent Clin North Am, 32, pp.411~435 (1988)
- Mohammed AH, "Leukotrienes in orthodontic tooth movement", Am J Orthod Dentofacial Orthop, 95, pp.231~237 (1989)
- Storey E, "The nature of tooth movement", Am J Orthod, 63, pp.292~314 (1973)
- Akin E, "Effects of nitric oxide in orthodontic tooth movement in rats", Am J Orthod Dentofacial Orthop, 126, pp.608~614 (2004)
- Murray RK, "Chapter 16. Physiological ?portance of Lipids, In Harper's Biochemistry" (1993), BarisYayinevi
- Leiker BJ, "The effects of exogenous prostaglandins on orthodontic tooth movement in rats", Am J Orthod Dentofacial Orthop, 108, pp.380~388 (1995)
- Seifi M, "The effect of prostaglandin E2 and calcium gluconate on ortho dontic tooth movement and root resorption in rats", Eur J Orthod, 25, pp.199~204 (2003)
- Reich KM, "Activation of G proteins mediates fl ow-induced prosta glan din E2 production in osteoblasts", Endocrinology, 138, pp.1014~1018 (1997)
- Yang RS, "Morphological changes induced by prostaglandin E in cultured rat osteoblasts", Bone, 22, pp.629~636 (1998)
- Kanzaki H, "Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prosta glandin E2 synthesis", J Bone Miner Res, 17, pp.210~220 (2002)
- Collins MK, "The local use of vitamin D to increase the rate of orthodontic tooth movement", Am J Orthod Dentofacial Orthop, 94, pp.278~284 (1988)
- Soma S, "Local and chronic application of PTH accelerates tooth movement in rats", J Dent Res, 79, pp.1717~1724 (2000)
- Ashcraft MB, "The effect of corticosteroid-induced osteoporosis on orthodontic tooth movement", Am J Orthod Dentofacial Orthop, 102, pp.310~319 (1992)
- Saito M, "Interleukin 1 beta and prostaglandin E are involved in the response of periodontal cells to mechanical stress in vivo and in vitro", Am J Orthod Dentofacial Orthop, 99, pp.226~240 (1991)
- Boekenoogen DI, "The effects of exogenous prostaglandin E2 on root resorption in rats", Am J Orthod Dentofacial Orthop, 109, pp.277~286 (1996)
- Brudvik P, "Root resorption after local injection of prostaglandin E2 during experimental tooth move-ment", Eur J Orthod, 13, pp.255~263 (1991)
- Lee WC, "Experimental study of the effect of prostaglandin administration on tooth movement--with particular emphasis on the relationship to the method of PGE1 administration", Am J Orthod Dentofacial Orthop, 98, pp.231~241 (1990)
- Roahen JO, "The effects of periodontal ligament injection on pulpal and periodontal tissues", J Endod, 16, pp.28~33 (1990)
- Tagger E, "Periodontal ligament injection in the dog primary dentition: spread of local anaesthetic solution", Int J Paediatr Dent, 4, pp.159~166 (1994)
- Fuhs QM, "The periodontal ligament injection: histological effects on the periodontium in dogs", J Endod, 9, pp.411~415 (1983)
- Odaci E, "The possible error sources of new stereological methods and their solutions", Turkiye Klinikleri J Med Sci, 24, pp.78~87 (2004)
- Graber TM, "Orthodontics: Current Principles and Techniques. 3rd ed", pp.193~257 (2000), Mosby
- Reitan K, "Clinical and histologic observations on tooth movement during and after orthodontic treatment", Am J Orthod, 53, pp.721~745 (1967)
- Ersoz M, "The changes in the hormones playing a role in the bone resorption and deposition during orthodontic tooth movement", 박사, pp.2004