Effects of Sub Minimal Inhibitory Concentration of Metronidazole and Penicillin on Morphology of Aggregatibacter actinomycetemcomitans: Scanning Electron Microscopy Observation
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Minimal inhibitory concentration (MIC) is the lowestconcentration of antibiotics that inhibits the visible growth ofbacteria. It has been reported that sub-MIC of antibioticsmay result in morphological alterations, along with thebiochemical and physiological changes in bacteria. Thepurpose of this study was to examine morphological changesof Aggregatibacter actinomycetemcomitans, after thetreatment with sub-MIC metronidazole and penicillin. Thebacterial morphology was observed with scanning electronmicroscope, after incubating with sub-MIC antibiotics. Thelength of A. actinomycetemcomitans was increased after theincubation with sub-MIC metronidazole and penicillin. Sub-MIC metronidazole and penicillin inhibited bacterialdivision and induced long filaments. Our study showed thatmetronidazole and penicillin can induce the morphologicalchanges in A. actinomycetemcomitans.
Abstract
Minimal inhibitory concentration (MIC) is the lowestconcentration of antibiotics that inhibits the visible growth ofbacteria. It has been reported that sub-MIC of antibioticsmay result in morphological alterations, along with thebiochemical and physiological changes in bacteria. Thepurpose of this study was to examine morphological changesof Aggregatibacter actinomycetemcomitans, after thetreatment with sub-MIC metronidazole and penicillin. Thebacterial morphology was observed with scanning electronmicroscope, after incubating with sub-MIC antibiotics. Thelength of A. actinomycetemcomitans was increased after theincubation with sub-MIC metronidazole and penicillin. Sub-MIC metronidazole and penicillin inhibited bacterialdivision and induced long filaments. Our study showed thatmetronidazole and penicillin can induce the morphologicalchanges in A. actinomycetemcomitans.
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