The effects of sex hormones on the expression of ODF/OPG in human gingival fibroblast and periodontal ligament cell at normal menstruation cycle and menopause
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Periodontitis is a chronic infectious disease that leads to periodontal destruction, and is one of the major causes of tooth loss in humans. The osteoclast differentiation factor(ODF), which is also known as the receptor activator of the NF-kB ligand (RANKL), is a surface-associated ligand on bone marrow stromal cells and osteoblasts. RANKL activates its cognate receptor, RANK, on osteoclast progenitor cells, which leads to the differentiation of mononucleated precursor cells. Osteoprotegerin (OPG) is a decoy receptor that is released from stromal cells and osteoblasts to inhibit the interaction between RANKL and RANK. Although the precise mechanism of bone loss in periodontitis is unknown, the differentiation and activation of osteoclasts by OPGODF-RANK signaling might play the role in periodontal bone destruction. The relationship between the concentration of sex hormones and the expression of ODF and OPG was examined by treating human gingival fibroblasts and periodontal ligament cells with the normal serum concentration of estrogen or progesterone during menstruation or at menopause. The ODF/OPG relative ratio was elevated at the concentration observed during ovulation in human gingival fibroblasts and at the concentration observed between ovulation and menstruation in periodontal ligament cells treated with estrogen. However, the ratio was < 1 at all concentrations in both cells treated with progesterone. In the case of menopause simulated by estrogen depletion, the ratio was < 1 in human gingival fibroblasts but > 1 in periodontal ligament cells.
Abstract
Periodontitis is a chronic infectious disease that leads to periodontal destruction, and is one of the major causes of tooth loss in humans. The osteoclast differentiation factor(ODF), which is also known as the receptor activator of the NF-kB ligand (RANKL), is a surface-associated ligand on bone marrow stromal cells and osteoblasts. RANKL activates its cognate receptor, RANK, on osteoclast progenitor cells, which leads to the differentiation of mononucleated precursor cells. Osteoprotegerin (OPG) is a decoy receptor that is released from stromal cells and osteoblasts to inhibit the interaction between RANKL and RANK. Although the precise mechanism of bone loss in periodontitis is unknown, the differentiation and activation of osteoclasts by OPGODF-RANK signaling might play the role in periodontal bone destruction. The relationship between the concentration of sex hormones and the expression of ODF and OPG was examined by treating human gingival fibroblasts and periodontal ligament cells with the normal serum concentration of estrogen or progesterone during menstruation or at menopause. The ODF/OPG relative ratio was elevated at the concentration observed during ovulation in human gingival fibroblasts and at the concentration observed between ovulation and menstruation in periodontal ligament cells treated with estrogen. However, the ratio was < 1 at all concentrations in both cells treated with progesterone. In the case of menopause simulated by estrogen depletion, the ratio was < 1 in human gingival fibroblasts but > 1 in periodontal ligament cells.
참고문헌 (35)
- Anderson, D.M, "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic cell function.", 390, pp.175~179 (1997)
- Aubin, J.E, "Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption.", 11, pp.905~913 (2000)
- Birkedal-Hansen, H, "Related articles role of cytokines and inflammatory mediators in tissue destruction.", 28, pp.50~510 (1993)
- Bostrom, L, "Clinical expression of TNF-alpha in smoking-associated periodontal disease.", 25, pp.767~773 (1998)
- Boyce, B.F, "Roles for NF-KappaB and c-fos in osteoclasts.", 23, pp.1~15 (2005)
- Brown, "Evaluating periodontal status of US employed adults. J. Am. Dent. Asoc. 121", pp.226~232 (1990)
- 72 Ji-Yearn Shin, "Mechanisms of initiation andprogression of periodontal disease. Periodontol. 2000. 2", pp.72~82 (1993)
- Eklund, "Risk factors for total tooth los in the United States longitudinal analysis of national data. J. Public Health Dent. 54", pp.5~14 (1994)
- Fukushima, H, "Expression and role of RANKL in periodontal ligament cells during physiological non-resorption in human deciduous teeth.", 11, pp.346~352 (2003)
- Galbraith, G.M, "Cytokine production by oral and peripheral blood neutrophils in adult periodontitis.", 68, pp.832~838 (1997)
- Hofbauer, L.C, "The OPG", RANKL, pp.2004., 3[DOI]
- Hofbauer, L.C, "Clinical implications of the osteoprotegerin", RANKL, pp.2004., 292[DOI]
- Klinger, G, "Influence of hormonal contraceptives on microbial flora of gingival sulcus. Contraception 57", 57, pp.381~384 (1998)
- Kong, Y.Y, "Activated T cels regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.", 401, pp.304~309 (1999)
- Kwon, B.S, "a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption", 12, pp.845~854 (1998)
- Lacey, D.L, "Osteoproteger in ligand is a cytokine that regulates osteoclast diferentiation and activation.", 93, pp.165~176 (1998)
- Liu, D, "Expression of RANKL and OPG mRNA in periodontal disease : possible involvement in bone destruction.", 1, pp.17~21 (2003)
- Lossdorfer, S, "Immunohistochemical localization of receptor activator of nuclear factor B(RANK) and its ligand(RANKL) in human deciduous teeth", 71, pp.45~52 (2002)
- Loza, J.C, "Osteoporosis and its relationship to oral bone loss.", 3, pp.27~33 (1996)
- Machtei, E.E, "The effect of menstrual cycle on periodontal health.", pp.408~412 (2004)
- Manolagas, S.C, "Birth and death of bone cells basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.", 21, pp.115~137 (2000)
- Mogi, M, "Diferential expresion of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis.", 83, pp.166~169 (2004)
- Nakagawa, "A longitudinal study of gingivitis from prepuberty to puberty. Correlation between the occurrence of Prevotella intermedia and sex hormones. J. Clin. Periodontol. 21", pp.658~665 (1994)
- Oshiro, T, "Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice.", 266, pp.218~225 (2002)
- J.E, "Experimental gingivitis during pregnancy and post-partum", endocri(logical), pp.21 549~558 (1994)
- K.H, "Tooth mobility changes during pregnancy. J. Peridont. Res. 2"
- Simonet, W.S, "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.", 89, pp.309~319 (1997)
- Tan, K.B, "Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive andinducible expression in hematopoietic and non- hematopoietic cels.", 204, pp.35~46 (1997)
- Tani-Ishi, N, "Autocrine regulation of osteoclast formation and bone resorption by IL-1 alpha and TNF alpha.", 78, pp.1617~1623 (1999)
- Tezal, M, "The relationship between bone mineral density and periodontitis in postmenopausal women.", 71, pp.1492~1498 (2000)
- Tsuda, E, "Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem. Biophys. Res. Commun. 234", 234, pp.137~142 (1997)
- Vitek, "Specific estrogen receptors in human gingiva. J. Clin. Endocrinol. Metab. 54", pp.608~612
- Vitek, "Progesterone receptors in human gingiva. The local direct effect of sex hormones on the local expression of OPG and ODF. 73 IRCS Med. Sci. 10", pp.381~384
- Wong, B.R, "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.", 272, pp.25190~25194 (1997)
- Yasuda, "Osteoclast differentiation factor is a ligand for osteoprotegerin", osteoclastogenesisinhibitoryfactor and is identical to TRANCE, pp.1998., 95[DOI]