The Effects of Sex Hormones on the Expression of ODF/OPG in Human Gingival Fibroblast and Periodontal Ligament Cell at Serum Concentration During Pregnancy
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Periodontitis is a chronic infectious disease that leads to the destruction, one of the major cause of tooth loss in human. Osteoclast Differentiation Factor(ODF), also called as Receptor activator of NF-κB ligand(RANKL), a surfaceassociated ligand on bone marrow stromal cells and osteoblasts, activates its cognate receptor RANK on osteoclast progenitor cells, which leads to differentiation of these mononucleated precursor cells. Osteoprotegerin(OPG), a decoy receptor, is released from stromal cells and osteoblasts to inhibit the interaction between RANKL and RANK. The experiment for the effect of pregnancy on gingival health showed greater gingival inflammation and edema during pregnancy, despite similar plaque index. There should be many factors affecting the periodontal health in pregnancy. In this experiment, we examined the direct effects of sex hormones(estrogen and progesterone) on the ODF/OPG expression in human gingival fibroblasts and periodontal ligament cells at the serum concentration of pregnancy. The ratio was high in the 1st trimester of pregnancy by estrogen and in the late 2nd trimester by progesterone. Therefore, the local periodontal destruction might be accelerated by these hormonal effect on the periodontal cells.
참고문헌 (24)
- "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendriticcell function.", 390, pp.175~179 (1997)
- "Evaluating periodontal status of US employed adults", pp.226~232 (1990)
- "Periodontol", 2, pp.72~82 (1993)
- "Risk factors for total tooth loss in the United States longitudinal analysis of national data", pp.5~14 (1994)
- "Expression and role of RANKL in periodontal ligament cells during physiological non-resorption in human deciduous teeth", 111, pp.346~352 (2003)
- "Periodontal infection and preterm birth; Results of a prospective study.", 132, pp.875~880 (2001)
- "TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption", 12, pp.845~854 (1998)
- "Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation", 93, pp.165~176 (1998)
- "Expression of RANKL and OPG mRNA in periodontal disease possible involvement in bone destruction", 11, pp.17~21 (2003)
- "Immunohistochemical localization of receptor activator of nuclear factor κB(RANK) and its ligand(RANKL) in human deciduous teeth.", 71, pp.45~52 (2002)
- "Osteoporosis and its relationship to oral bone loss", 3, pp.27~33 (1996)
- "Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis", 83, pp.166~169 (2004)
- "Periodontal infection as a possible risk factor for preterm bow birth weight", 67, pp.1103~1113 (1996)
- "Maternal T-Lymphocyte response and gingivitis in pregnancy", pp.178~184 (1979)
- "J Periodont", 50, pp.279~282 (1979)
- "Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice. 110 Ji-Yearn Shin et al.", 266, pp.218~225 (2002)
- "Tooth mobility changes during pregnancy"
- "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.", 89, pp.309~319 (1997)
- "Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells.", 204, pp.35~46 (1997)
- "Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.", 234, pp.137~142 (1997)
- "Specific estrogen receptors in human gingiva", j clin endocri(l metab), pp.608~612 (1982)
- "Progesterone receptors in human gingiva", pp.381~384 (1982)
- "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells", 272, pp.25190~25194 (1997)
- "Osteoclast differentiation factor is a ligand for osteoprotegerin", osteoclastogenesis-inhibitory factor and is identical to TRANCE, pp.1998, 95[DOI]