Effect of Solanum Melongena Extract on the Xanthine Oxidase Inhibitory, Nitrite Scavenging, and Angiotensin I-Converting Enzyme Inhibitory Activities
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This research was to study effect of Solanum melongena extract on the xanthine oxidase (XO) inhibitory, nitrite scavenging (NC), and angiotensin I-converting enzyme (ACE) inhibitory activities. All the extracts inhibited the XO and ACE activities in a dose dependent manner. Especially, among various extracts, when 6.0 mg/mL of acetone extract was used, the maximum activity of XO inhibitory was obtained, 65.2%. On the other hand, in the case of methanol and ethanol extracts, they ranged of 61.5 to 62.4%. Acetone extract had a high phenolics and flavonoid concentration compared to other extraxts. Maximum NC activity using hot water extract at pH 1.2 was occurred, 68.7%. ACE inhibitory activity was significantly different among the various extracts at 6.0 mg/mL, values ranged from 35.26 to 56.7%. Especially, when 6.0 mg/mL of methanol and ethanol extracts were used, the highest ACE inhibitory activities were obtained, 57.3 and 56.7%, respectively. These results suggest that XO inhibitory, NC, and ACE inhibitory activities of S. melongena extract were strongly affected by extractant.
Abstract
This research was to study effect of Solanum melongena extract on the xanthine oxidase (XO) inhibitory, nitrite scavenging (NC), and angiotensin I-converting enzyme (ACE) inhibitory activities. All the extracts inhibited the XO and ACE activities in a dose dependent manner. Especially, among various extracts, when 6.0 mg/mL of acetone extract was used, the maximum activity of XO inhibitory was obtained, 65.2%. On the other hand, in the case of methanol and ethanol extracts, they ranged of 61.5 to 62.4%. Acetone extract had a high phenolics and flavonoid concentration compared to other extraxts. Maximum NC activity using hot water extract at pH 1.2 was occurred, 68.7%. ACE inhibitory activity was significantly different among the various extracts at 6.0 mg/mL, values ranged from 35.26 to 56.7%. Especially, when 6.0 mg/mL of methanol and ethanol extracts were used, the highest ACE inhibitory activities were obtained, 57.3 and 56.7%, respectively. These results suggest that XO inhibitory, NC, and ACE inhibitory activities of S. melongena extract were strongly affected by extractant.
참고문헌 (19)
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