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여주 초음파 추출물의 항산화, 항당뇨 및 항염 활성

Antioxidant, antidiabetic and anti-inflammatory activities of bitter melon extracts obtained by ultrasonic-assisted extraction

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초록

We obtained polyphonol extracts from bitter melon containing various bioactive compounds to improve applicability as functional food materials. The total phenolic content (TPC), antioxidant, antidiabetic, and anti-inflammatory activities of bitter melon extracts obtained using various extraction methods were compared. The extracts obtained using ethanol as the solvent had a higher TPC than extracts obtained using water. The extracts obtained using ethanol also had high antioxidant, antidiabetic, and anti-inflammatory activities when performed using ultrasonic-assisted extraction (UE) with ethanol. The extract obtained using probe type-UE with ethanol (PUE-E) exhibited α-amylase and α-glucosidase inhibitory activity levels corresponding to 90% or more of acarbose (a diabetes treatment). An extract obtained using a bath type-UE with ethanol (BUE-E) exhibited high NO inhibitory activity at all concentrations. Therefore, UE with ethanol is a very effective method for recovering polyphenol extracts from bitter melon with antioxidant, antidiabetic, and anti-inflammatory activities. In addition, the polyphenol extracts obtained from bitter melon by UE with ethanol (especially PUE-E and BUE-E) have a high application potential as functional food materials.

Abstract

We obtained polyphonol extracts from bitter melon containing various bioactive compounds to improve applicability as functional food materials. The total phenolic content (TPC), antioxidant, antidiabetic, and anti-inflammatory activities of bitter melon extracts obtained using various extraction methods were compared. The extracts obtained using ethanol as the solvent had a higher TPC than extracts obtained using water. The extracts obtained using ethanol also had high antioxidant, antidiabetic, and anti-inflammatory activities when performed using ultrasonic-assisted extraction (UE) with ethanol. The extract obtained using probe type-UE with ethanol (PUE-E) exhibited α-amylase and α-glucosidase inhibitory activity levels corresponding to 90% or more of acarbose (a diabetes treatment). An extract obtained using a bath type-UE with ethanol (BUE-E) exhibited high NO inhibitory activity at all concentrations. Therefore, UE with ethanol is a very effective method for recovering polyphenol extracts from bitter melon with antioxidant, antidiabetic, and anti-inflammatory activities. In addition, the polyphenol extracts obtained from bitter melon by UE with ethanol (especially PUE-E and BUE-E) have a high application potential as functional food materials.

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