Clinical traits and systemic risks of familial diabetes mellitus according to age of onset and quantity: an analysis of data from the community-based KoGES cohort study
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OBJECTIVES: The aim of this study was to clarify the clinical trait of familial diabetes mellitus (DM) by analyzing participants’ risk of DM according to the age of DM onset in parents and siblings, and to evaluate individuals’ risk of DM-associated cardiometabolic diseases. METHODS: Altogether, 211,173 participants aged ≥40 years from the Korean Genome and Epidemiology Study were included in this study. The participants were divided into groups based on the number (1 or 2 relatives) and age of onset (no DM and early, common, or late onset) of familial DM. Participants’ risk of DM was assessed using a Cox regression model with hazard ratios and 95% confidence intervals (CIs). A logistic regression model with odds ratios was used to evaluate associations among the participants’ likelihood of acquiring cardiometabolic diseases such as hypertension, chronic kidney disease (CKD), and cardiovascular disease. RESULTS: The risk of developing DM was 2.02-fold (95% CI, 1.88 to 2.18) and 2.88-fold (95% CI, 2.50 to 3.33) higher, respectively, in participants with 1 and 2 family members diagnosed with familial DM. It was 2.72-fold (95% CI, 2.03 to 3.66) higher in those with early-onset familial DM. In the early-onset group, the respective risks of hypertension and CKD were 1.87-fold (95% CI, 1.37 to 2.55) and 4.31-fold (95% CI, 2.55 to 7.27) higher than in the control group. CONCLUSIONS: The risk of DM and related cardiometabolic diseases was positively associated with the number of family members diagnosed with DM and an early diagnosis in family members with DM.
Abstract
OBJECTIVES: The aim of this study was to clarify the clinical trait of familial diabetes mellitus (DM) by analyzing participants’ risk of DM according to the age of DM onset in parents and siblings, and to evaluate individuals’ risk of DM-associated cardiometabolic diseases. METHODS: Altogether, 211,173 participants aged ≥40 years from the Korean Genome and Epidemiology Study were included in this study. The participants were divided into groups based on the number (1 or 2 relatives) and age of onset (no DM and early, common, or late onset) of familial DM. Participants’ risk of DM was assessed using a Cox regression model with hazard ratios and 95% confidence intervals (CIs). A logistic regression model with odds ratios was used to evaluate associations among the participants’ likelihood of acquiring cardiometabolic diseases such as hypertension, chronic kidney disease (CKD), and cardiovascular disease. RESULTS: The risk of developing DM was 2.02-fold (95% CI, 1.88 to 2.18) and 2.88-fold (95% CI, 2.50 to 3.33) higher, respectively, in participants with 1 and 2 family members diagnosed with familial DM. It was 2.72-fold (95% CI, 2.03 to 3.66) higher in those with early-onset familial DM. In the early-onset group, the respective risks of hypertension and CKD were 1.87-fold (95% CI, 1.37 to 2.55) and 4.31-fold (95% CI, 2.55 to 7.27) higher than in the control group. CONCLUSIONS: The risk of DM and related cardiometabolic diseases was positively associated with the number of family members diagnosed with DM and an early diagnosis in family members with DM.
참고문헌 (17)
- Wehby GL, "Genetic risks for chronic conditions : implications for long-term wellbeing", J Gerontol A Biol Sci Med Sci, 73, pp.477~483 (2018)
- Valdez R, "Family history and prevalence of diabetes in the U. S. population : the 6-year results from the National Health and Nutrition Examination Survey(1999-2004)", Diabetes Care, 30, pp.2517~2522 (2007)
- InterAct Consortium; Scott RA, "The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors : the EPIC-InterAct study", Diabetologia, 56, pp.60~69 (2013)
- 원종철, "Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status", Diabetes and Metabolism Journal, 42(5), pp.415~424 (2018), 대한당뇨병학회[DOI]
- 신지연, "Trends in the prevalence and management of diabetes in Korea: 2007-2017", Epidemiology and Health, 41, pp.1~9 (2019), 한국역학회[DOI]
- Kim Y, "Cohort profile : the Korean Genome and Epidemiology Study(KoGES)consortium", Int J Epidemiol, 46, pp.1350~ (2017)
- Zou X, "The characteristics of newly diagnosed adult early-onset diabetes : a population-based cross-sectional study", Sci Rep, 7, pp.46534~ (2017)
- Cummings P, "On the need for the rare disease assumption in some case-control studies", Inj Prev, 7, pp.254~ (2001)
- Alharithy MK, "Impact of family history of diabetes on diabetes control and complications", Endocr Pract, 24, pp.773~779 (2018)
- Thorn LM, "Effect of parental type 2 diabetes on offspring with type 1 diabetes", Diabetes Care, 32, pp.63~68 (2009)
- Malih Narges, "Determinants of Adherence to Diabetes Screening in Iranian Adults With a Positive Family History of Diabetes", 예방의학회지, 54(3), pp.190~198 (2021), 대한예방의학회[DOI]
- Gillespie KM, "High familial risk and genetic susceptibility in early onset childhood diabetes", Diabetes, 51, pp.210~214 (2002)
- Harjutsalo V, "Cumulative incidence of type 1 diabetes in 10, 168 siblings of Finnish young-onset type 1 diabetic patients", Diabetes, 54, pp.563~569 (2005)
- Harjutsalo V, "Age at onset of type 1 diabetes in parents and recurrence risk in offspring", Diabetes, 59, pp.210~214 (2010)
- Gupta L, "Factors determining the success of therapeutic lifestyle interventions in diabetes-role of partner and family support", Eur Endocrinol, 15, pp.18~24 (2019)
- Yang J, "Modifiable risk factors and long term risk of type 2 diabetes among individuals with a history of gestational diabetes mellitus : prospective cohort study", BMJ, 378, pp.e070312~ (2022)
- 심선영, "Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults", Epidemiology and Health, 43, pp.1~7 (2021), 한국역학회[DOI]