당뇨병가족력 여부에 따른 공복혈당장애율
Impaired Fasting Glucose Rate by Diabetes Family History
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Objectives: This study was to investigate the prevalence of impaired fasting glucose and the influence of a family history of type 2 diabetes on it. Methods: The data was used from National Health and Nutrition Survey in 2013. Among 5,185 subjects aged 19 to 69 years, 3,561 were selected after excluding the data of previous diagnosis of diabetes, fasting plasma glucose (FPG)≥126 mg/dL, HbA1c≥6.5%, or missing values of diabetes family history. Impaired fasting glucose was defined as FPG of 100 to 125 mg/dL. We analyzed the prevalence of impaired fasting glucose and the influences of the related factors including a family history of type 2 diabetes on it using the logistic regression model. Results: The prevalence of impaired fasting glucose in non-diabetes Korean population was 20.9%. 682 (19.2%) had a family history in at least one first degree relative and it was significantly associated with impaired fasting glucose (p=0.020). A family history in brothers or sisters was significantly associated to IFG (p<0.001), that in father (p=0.335) or mother (p=0.067) was not. After adjustment for known risk factors related to diabetes including age, sex, smoke, drinking, body mass index (BMI), hypertension and dyslipidemia, a family history of type 2 diabetes was associated with impaired fasting glucose, the odds ratio for it was 1.40 (1.13-1.73). Conclusions: The family history of type 2 diabetes is a major risk factor of impaired fasting glucose in general adults and more effort is needed for early detection and prevention of impaired fasting glucose in case with family history.
Abstract
Objectives: This study was to investigate the prevalence of impaired fasting glucose and the influence of a family history of type 2 diabetes on it. Methods: The data was used from National Health and Nutrition Survey in 2013. Among 5,185 subjects aged 19 to 69 years, 3,561 were selected after excluding the data of previous diagnosis of diabetes, fasting plasma glucose (FPG)≥126 mg/dL, HbA1c≥6.5%, or missing values of diabetes family history. Impaired fasting glucose was defined as FPG of 100 to 125 mg/dL. We analyzed the prevalence of impaired fasting glucose and the influences of the related factors including a family history of type 2 diabetes on it using the logistic regression model. Results: The prevalence of impaired fasting glucose in non-diabetes Korean population was 20.9%. 682 (19.2%) had a family history in at least one first degree relative and it was significantly associated with impaired fasting glucose (p=0.020). A family history in brothers or sisters was significantly associated to IFG (p<0.001), that in father (p=0.335) or mother (p=0.067) was not. After adjustment for known risk factors related to diabetes including age, sex, smoke, drinking, body mass index (BMI), hypertension and dyslipidemia, a family history of type 2 diabetes was associated with impaired fasting glucose, the odds ratio for it was 1.40 (1.13-1.73). Conclusions: The family history of type 2 diabetes is a major risk factor of impaired fasting glucose in general adults and more effort is needed for early detection and prevention of impaired fasting glucose in case with family history.
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