Genetically determined alcohol consumption and cancer risk in Korea
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
OBJECTIVES: The purpose of this study was to determine the causal relationship between the genetically determined amount of alcohol consumption and the occurrence of major cancers. METHODS: The data used in this study were from 129,324 people selected from the Korean Cancer Prevention Study-II, the participants of which visited 18 health examination centers between 2004 and 2013. Cancer incidence was confirmed as of 2020 using data from the National Cancer Center. A genome-wide association study (GWAS) on alcohol consumption was performed using PLINK 2.0, and sex, age, chip type, and principal components were adjusted. RESULTS: From the GWAS, a genetic risk score for alcohol consumption was calculated and genetically determined alcohol consumption (GDAC) was estimated. GDAC was divided into quintile groups and showed significant causal relationships with rectal cancer and liver cancer, but not with other cancers. For liver cancer, an association was shown in the hepatitis B surface antigen (HBsAg)-negative group, and a particularly strong association was found in the over-60-year-old HBsAg-negative group, in which, compared to the GDAC Q1 group, the Q4 group had a 2.35 times higher risk (95% confidence interval [CI], 1.05 to 5.23), and the Q5 group had a 2.40 times higher risk (95% CI, 1.09 to 5.30). CONCLUSIONS: The results of this study provided evidence that the amount of alcohol consumed is causally related to the occurrence of rectal cancer and liver cancer in HBsAg-negative individuals. Additional studies should be continued for other cancer types through long-term follow-up.
Abstract
OBJECTIVES: The purpose of this study was to determine the causal relationship between the genetically determined amount of alcohol consumption and the occurrence of major cancers. METHODS: The data used in this study were from 129,324 people selected from the Korean Cancer Prevention Study-II, the participants of which visited 18 health examination centers between 2004 and 2013. Cancer incidence was confirmed as of 2020 using data from the National Cancer Center. A genome-wide association study (GWAS) on alcohol consumption was performed using PLINK 2.0, and sex, age, chip type, and principal components were adjusted. RESULTS: From the GWAS, a genetic risk score for alcohol consumption was calculated and genetically determined alcohol consumption (GDAC) was estimated. GDAC was divided into quintile groups and showed significant causal relationships with rectal cancer and liver cancer, but not with other cancers. For liver cancer, an association was shown in the hepatitis B surface antigen (HBsAg)-negative group, and a particularly strong association was found in the over-60-year-old HBsAg-negative group, in which, compared to the GDAC Q1 group, the Q4 group had a 2.35 times higher risk (95% confidence interval [CI], 1.05 to 5.23), and the Q5 group had a 2.40 times higher risk (95% CI, 1.09 to 5.30). CONCLUSIONS: The results of this study provided evidence that the amount of alcohol consumed is causally related to the occurrence of rectal cancer and liver cancer in HBsAg-negative individuals. Additional studies should be continued for other cancer types through long-term follow-up.
참고문헌 (23)
- Lewandowska AM, "Environmental risk factors for cancer-review paper", Ann Agric Environ Med, 26, pp.1~7 (2019)
- Rumgay H, "Alcohol and cancer : epidemiology and biological mechanisms", Nutrients, 13, pp.3173~ (2021)
- Bagnardi V, "Alcohol consumption and site-specific cancer risk : a comprehensive dose-response meta-analysis", Br J Cancer, 112, pp.580~593 (2015)
- Bagnardi V, "Light alcohol drinking and cancer : a meta-analysis", Ann Oncol, 24, pp.301~308 (2013)
- Larsson SC, "Smoking, alcohol consumption, and cancer : a mendelian randomisation study in UK Biobank and international genetic consortia participants", PLoS Med, 17, pp.e1003178~ (2020)
- Liu M, "Association studies of up to 1. 2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use", Nat Genet, 51, pp.237~244 (2019)
- 최창균, "Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans", Cancer Research and Treatment, 53(3), pp.754~762 (2021), 대한암학회[DOI]
- Jee YH, "Cohort profile : the Korean Cancer Prevention Study-II(KCPS-II)Biobank", Int J Epidemiol, 47, pp.385~386 (2018)
- Cherukuri PF, "Establishing analytical validity of BeadChip array genotype data by comparison to whole-genome sequence and standard benchmark datasets", BMC Med Genomics, 15, pp.56~ (2022)
- Moon S, "The Korea Biobank Array : design and identification of coding variants associated with blood biochemical traits", Sci Rep, 9, pp.1382~ (2019)
- Park S, "Weighting approaches for a genetic risk score and an oxidative stress score for predicting the incidence of obesity", Diabetes Metab Res Rev, 36, pp.e3230~ (2020)
- 강미주, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019", Cancer Research and Treatment, 54(2), pp.330~344 (2022), 대한암학회[DOI]
- 정규원, "Prediction of Cancer Incidence and Mortality in Korea, 2023", Cancer Research and Treatment, 55(2), pp.400~407 (2023), 대한암학회[DOI]
- Clarke TK, "Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank(N=112 117)", Mol Psychiatry, 22, pp.1376~1384 (2017)
- 강미주, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2020", Cancer Research and Treatment, 55(2), pp.385~399 (2023), 대한암학회[DOI]
- Donato F, "Alcohol and hepatocellular carcinoma : the effect of lifetime intake and hepatitis virus infections in men and women", Am J Epidemiol, 155, pp.323~331 (2002)
- Franceschi S, "Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy", Cancer Epidemiol Biomarkers Prev, 15, pp.683~689 (2006)
- Jee SH, "Cigarette smoking, alcohol drinking, hepatitis B, and risk for hepatocellular carcinoma in Korea", J Natl Cancer Inst, 96, pp.1851~1856 (2004)
- Byeong Geun Song, "Changes in the prevalence of hepatitis B and metabolic abnormalities among young men in Korea", The Korean Journal of Internal Medicine, 37(5), pp.1082~1087 (2022), 대한내과학회[DOI]
- Marengo A, "Liver cancer : connections with obesity, fatty liver, and cirrhosis", Annu Rev Med, 67, pp.103~117 (2016)
- Liu Z, "Alcohol consumption and hepatocellular carcinoma : novel insights from a prospective cohort study and nonlinear Mendelian randomization analysis", BMC Med, 20, pp.413~ (2022)
- Deng Y, "Associations between six dietary habits and risk of hepatocellular carcinoma : a Mendelian randomization study", Hepatol Commun, 6, pp.2147~2154 (2022)
- Park SY, "Alcohol Intake and colorectal cancer risk in the multiethnic cohort study", Am J Epidemiol, 188, pp.67~76 (2019)