본문 바로가기
KERD
논문KCI 등재

Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis

3

조회

0

다운로드

2

인용

0

참고문헌

키워드

초록

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

Abstract

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

참고문헌 (49)

  1. Sung H, "Global cancer statistics 2020 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA Cancer J Clin, 71, pp.209~249 (2021)
  2. Rehm J, "The relationship between different dimensions of alcohol use and the burden of disease-an update", Addiction, 112, pp.968~1001 (2017)
  3. "Alcohol drinking", IARC Monogr Eval Carcinog Risks Hum, 44, pp.1~378 (1988)
  4. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, "Alcohol consumption and ethyl carbamate", IARC Monogr Eval Carcinog Risks Hum, 96, pp.3~1383 (2010)
  5. Cogliano VJ, "Preventable exposures associated with human cancers", J Natl Cancer Inst, 103, pp.1827~1839 (2011)
  6. Rumgay H, "Global burden of cancer in 2020 attributable to alcohol consumption : a population-based study", Lancet Oncol, 22, pp.1071~1080 (2021)
  7. Di Castelnuovo A, "Alcohol dosing and total mortality in men and women : an updated meta-analysis of 34 prospective studies", Arch Intern Med, 166, pp.2437~2445 (2006)
  8. Bagnardi V, "Flexible meta-regression functions for modeling aggregate dose-response data, with an application to alcohol and mortality", Am J Epidemiol, 159, pp.1077~1086 (2004)
  9. Ko H, "Low-level alcohol consumption and cancer mortality", Sci Rep, 11, pp.4585~ (2021)
  10. Gaziano JM, "Light-to-moderate alcohol consumption and mortality in the Physicians’ Health Study enrollment cohort", J Am Coll Cardiol, 35, pp.96~105 (2000)
  11. Bagnardi V, "Light alcohol drinking and cancer : a meta-analysis", Ann Oncol, 24, pp.301~308 (2013)
  12. Rehm J, "Alcohol use and cancer in the European Union", Eur Addict Res, 27, pp.1~8 (2021)
  13. Conigrave KM, "Revision of the Australian guidelines to reduce health risks from drinking alcohol", Med J Aust, 215, pp.518~524 (2021)
  14. "National low-risk drinking recommendations (or drinking guidelines) and standard units" (2022)[URL]
  15. Boyle P, "European Code Against Cancer and scientific justification : third version(2003)", Ann Oncol, 14, pp.973~1005 (2003)
  16. Scoccianti C, "European Code against Cancer 4th Edition : alcohol drinking and cancer", Cancer Epidemiol, 45, pp.181~188 (2016)
  17. "Cancer prevention program" (2023)[URL]
  18. Myung SK, "Erroneous conclusions about the association between light alcohol drinking and the risk of cancer : comments on Bagnardi et al. ’s meta-analysis", Ann Oncol, 27, pp.2138~ (2016)
  19. 최윤정, "Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies", Cancer Research and Treatment, 50(2), pp.474~487 (2018), 대한암학회
  20. "World cancer report 2014"[URL]
  21. 정금지, "Genetically determined alcohol consumption and cancer risk in Korea", Epidemiology and Health, 45, pp.077~077 (2023), 한국역학회[DOI]
  22. Patra J, "Alcohol consumption and the risk of morbidity and mortality for different stroke types--a systematic review and meta-analysis", BMC Public Health, 10, pp.258~ (2010)
  23. "The Newcastle Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analysis" (2021)[URL]
  24. "Cochrane handbook for systematic reviews of interventions version 5.1.0" (2011)[URL]
  25. 심성률, "Dose-response meta-analysis: application and practice using the R software", Epidemiology and Health, 41, pp.1~7 (2019), 한국역학회
  26. Pustejovsky JE, "Testing for funnel plot asymmetry of standardized mean differences", Res Synth Methods, 10, pp.57~71 (2019)
  27. Sterne JA, "Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials", BMJ, 343, pp.d4002~ (2011)
  28. 오진경, "Awareness of and practice toward cancer prevention recommendations: results of the Korean National Cancer Prevention Awareness and Practice Survey in 2021", Epidemiology and Health, 44, pp.1~11 (2022), 한국역학회[DOI]
  29. Sami Lee, "Current Status of Korean Alcohol Drinking in Accordance with the Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing", Korean Journal of Family Medicine, 44(3), pp.129~142 (2023), 대한가정의학회[DOI]
  30. "Global status report on alcohol and health 2018"[URL]
  31. Korea Centers for Disease Control and Prevention, "2021 Korea national health statistics", Korea Centers for Disease Control and Prevention, 63~71 (2022)
  32. "The 2020 Korea Welfare Panel Study (KoWePS): a descriptive report"[URL]
  33. "Cancer incidence, by type of cancer" (2023)[URL]
  34. Stockwell T, "Do"moderate"drinkers have reduced mortality risk? A systematic review and meta-analysis of alcohol consumption and all-cause mortality", J Stud Alcohol Drugs, 77, pp.185~198 (2016)
  35. Thi Tra Bui, "Cancer Risk According to Alcohol Consumption Trajectories: A Population-based Cohort Study of 2.8 Million Korean Men", Journal of Epidemiology, 33(12), pp.624~632 (2023), Japan Epidemiological Association[DOI]
  36. Yoo JE, "Association of the frequency and quantity of alcohol consumption with gastrointestinal cancer", JAMA Netw Open, 4, pp.e2120382~ (2021)
  37. Zhao J, "Is alcohol consumption a risk factor for prostate cancer? A systematic review and meta-analysis", BMC Cancer, 16, pp.845~ (2016)
  38. Johnson CH, "Molecular mechanisms of alcohol-induced colorectal carcinogenesis", Cancers(Basel), 13, pp.4404~ (2021)
  39. Goedde HW, "Distribution of ADH2 and ALDH2 genotypes in different populations", Hum Genet, 88, pp.344~346 (1992)
  40. Bagnardi V, "Alcohol consumption and the risk of cancer : a meta-analysis", Alcohol Res Health, 25, pp.263~270 (2001)
  41. Chen WY, "Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk", JAMA, 306, pp.1884~1890 (2011)
  42. Hamajima N, "Alcohol, tobacco and breast cancer—collaborative reanalysis of individual data from 53 epidemiological studies, including 58, 515 women with breast cancer and 95, 067 women without the disease", Br J Cancer, 87, pp.1234~1245 (2002)
  43. Singletary KW, "Alcohol and breast cancer : review of epidemiologic and experimental evidence and potential mechanisms", JAMA, 286, pp.2143~2151 (2001)
  44. 홍승희, "Alcohol Intake and Risk of Thyroid Cancer: A Meta-Analysis of Observational Studies", Cancer Research and Treatment, 49(2), pp.534~547 (2017), 대한암학회
  45. Zoeller RT, "Chronic ethanol treatment reduces the responsiveness of the hypothalamic-pituitary-thyroid axis to central stimulation", Alcohol Clin Exp Res, 20, pp.954~960 (1996)
  46. Valeix P, "Effects of light to moderate alcohol consumption on thyroid volume and thyroid function", Clin Endocrinol(Oxf), 68, pp.988~995 (2008)
  47. Islami F, "Alcohol drinking and laryngeal cancer : overall and dose-risk relation--a systematic review and meta-analysis", Oral Oncol, 46, pp.802~810 (2010)
  48. Ekholm O, "Influence of the recall period on self-reported alcohol intake", Eur J Clin Nutr, 58, pp.60~63 (2004)
  49. Heeb JL, "Measuring alcohol consumption : a comparison of graduated frequency, quantity frequency, and weekly recall diary methods in a general population survey", Addict Behav, 30, pp.403~413 (2005)

관련 논문AI추천

Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies명승권, 이지호, 최윤정대한암학회 · Cancer Research and Treatment2018 · 제50권 제2호Alcohol as a Risk Factor for Cancer: Existing Evidence in a Global PerspectiveElisabete Weiderpass, Nina Roswall대한예방의학회 · 예방의학회지2015 · 제48권 제1호Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer신승각, 주이진, Jang Jeong Won, Park Hana, Park Joong-Won, Song Do Seon거트앤리버 소화기연관학회협의회 · Gut and Liver2020 · 제14권 제6호Preventable cancer cases and deaths attributable to alcohol consumption in Korea from 2015 to 2030이상욱, An Jihye, Choi Seung Ho, Choi Yoon-Jung, Hong Youjin, Jee Sun Ha, Jeong-Soo Im, Jung Jeehi, Kim In-ah, Kim Jeongseon, Kim Kyungsik, Ko Kwang-Pil, Kweon Sun-Seog, Lee Hyeon Sook, Lee Jung Eun, Lee Sangjun, Lim Woojin, Moon Sungji, Park Sang Min, Park So Hee, Park Sue K., Ryu Seungho, Seo Hong Gwan, Shin Aesun, Shin Min-Ho, Sung Soseul, Yang Sun Young한국역학회 · Epidemiology and Health2025 · 제47권 Alcohol Consumption and Mortality in the Korean Multi-center Cancer Cohort Study강대희, 마승현, 박보영, 신애선, 신해림, 유근영, 이은하, 장성훈, 조인성, En-Joo Jung, Sue K. Park대한예방의학회 · 예방의학회지2012 · 제45권 제5호Alcohol consumption and gastric cancer risk in Korea: a case-control studyBo Youl Choi, Chang Soo Eun, Chan Hyuk Park, Dong Soo Han, Hyun Ja Kim, Kyu Sang Song, Mi Hui Kim, Shin Ah Kim, Yong Sung Kim한국영양학회 · Nutrition Research and Practice2019 · 제13권 제5호

이 간행물의 다른 논문 (102건)

Changes in health behaviors and obesity of Korean adolescents before and during the COVID-19 pandemic: a special report using the Korea Youth Risk Behavior SurveyChoi Sunhye, Oh Kyungwon, 오창모, Kim Yangha, Yang Ji Eunpp. 1-8Korea Seroprevalence Study of Monitoring of SARS-COV-2 Antibody Retention and Transmission (K-SEROSMART): findings from national representative sample황태윤, 오경재, 홍영습, Kim Su Young, 이계오, 윤규현, 김정애, 이혁민, 신민호, 이순영, 이원영, 김동현, 박재현, 이훈재, 조성일, 남해성, 이무식, Lee June-Woo, Kim Sung Soon, 설로마, Kim Byoungguk, 이중정, 오창모, Jung Sun Jae, 오성수, Yim Hyeon Woo, 한미아, 김유미, 조희숙, Lee Ju-Hyung, Jung Jaehun, Kim Ah-Ra, Han Jina, Baek Hye Jin, Noh Eunbi, Ryu Sukhyun, 박노례, Jung Eunok, Kim Sang Il, Hwang Yoo-Sung, Oh Sangcheol, Kim Migyeong, Yu Byengchul, Kim Keonyeop, Hwangbo Young, Lee Joongyub, Kim Hyeongsu, Kang Gilwon, Ryu So Yeon, Park Soon-Woo, Kim Sang Kyu, Park Ki Soo, Kwon Jun-wook, Jang Eun Young, Nam Jeonghyunpp. 1-13Genetically determined alcohol consumption and cancer risk in Korea지선하, 정금지, 백지우, Shin Sang Yoppp. 1-7Self-reported adverse events after 2 doses of COVID-19 vaccine in Korea고미정, 김형준, 황인섭, Kwon Yunhyung, Kim Seontae, Seo Soon-Young, Cho Enhi, Yeon-Kyeng Leepp. 1-7Detecting mpox infection in the early epidemic: an epidemiologic investigation of the third and fourth cases in KoreaChoi Jihyun, Choi Yunsang, Kim Jong Mu, 박숙경, Kim Taeyoung, Park Eonjoo, Eun Juk Suk, Lee Eun-young, Mun Ji Won, Lee Sinyoung, Yeom Hansol, Kim Eun Kyoung, Ha Jinhopp. 1-7