Alcohol consumption and gastric cancer risk in Korea: a case-control study
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BACKGROUND/OBJECTIVES: The International Agency for Research on Cancer defined alcohol beverages and acetaldehyde derived from alcoholic beverages as a Group 1 carcinogen to humans. However, the association between alcohol consumption and gastric cancer risk has been controversial in Korean. We assessed the relationship between alcohol consumption and gastric cancer risk in Korea through a case-control study. SUBJECTS/METHODS: From 2 hospitals, a total of 316 cases with gastric cancer (208 men, 108 women) were selected and matched to 316 controls by sex and age (± 5 years) during the same duration. The current status, frequency, and amount of alcohol consumption for a year three years ago were assessed by trained interviewers. RESULTS: Alcohol consumption status and frequency did not show any significant association with gastric cancer risk. However, high alcohol consumption (≥ 20 g/day for women or ≥ 40 g/day for men) significantly increased the risk of gastric cancer (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.05-2.85). Gastric cancer risk was strongly positively associated with alcohol consumption of ≥ 20 g/day, especially in women (OR 5.62; 95% CI 1.32-23.81). CONCLUSION: The results from this study suggest that excessive alcohol consumption rather than the current status or frequency of alcohol consumption contributes to the increased risk of gastric cancer, especially in women.
Abstract
BACKGROUND/OBJECTIVES: The International Agency for Research on Cancer defined alcohol beverages and acetaldehyde derived from alcoholic beverages as a Group 1 carcinogen to humans. However, the association between alcohol consumption and gastric cancer risk has been controversial in Korean. We assessed the relationship between alcohol consumption and gastric cancer risk in Korea through a case-control study. SUBJECTS/METHODS: From 2 hospitals, a total of 316 cases with gastric cancer (208 men, 108 women) were selected and matched to 316 controls by sex and age (± 5 years) during the same duration. The current status, frequency, and amount of alcohol consumption for a year three years ago were assessed by trained interviewers. RESULTS: Alcohol consumption status and frequency did not show any significant association with gastric cancer risk. However, high alcohol consumption (≥ 20 g/day for women or ≥ 40 g/day for men) significantly increased the risk of gastric cancer (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.05-2.85). Gastric cancer risk was strongly positively associated with alcohol consumption of ≥ 20 g/day, especially in women (OR 5.62; 95% CI 1.32-23.81). CONCLUSION: The results from this study suggest that excessive alcohol consumption rather than the current status or frequency of alcohol consumption contributes to the increased risk of gastric cancer, especially in women.
참고문헌 (47)
- Torre LA, "Global cancer incidence and mortality rates and trends-an update", Cancer Epidemiol Biomarkers Prev, 25, pp.16~27 (2016)
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015", Cancer Research and Treatment, 50(2), pp.303~316 (2018), 대한암학회
- Guggenheim DE, "Gastric cancer epidemiology and risk factors", J Surg Oncol, 107, pp.230~236 (2013)
- Lichtenstein P, "Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland", N Engl J Med, 343, pp.78~85 (2000)
- IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, "International Agency for Research on Cancer", World Health Organization, ~ (1988)
- Pöschl G, "Alcohol and cancer", Alcohol Alcohol, 39, pp.155~165 (2004)
- Diet, Nutrition, Physical Activity, and Stomach Cancer, "World Cancer Research Fund International", World Cancer Research Fund International, ~ (2016)
- Tramacere I, "A meta-analysis on alcohol drinking and gastric cancer risk", Ann Oncol, 23, pp.28~36 (2012)
- Kim HJ, "Dietary factors and gastric cancer in Korea: a case-control study", Int J Cancer, 97, pp.531~535 (2002)
- 이정엽, "위암 환자의 식이와 위암조직의 pS2 promoter 과 메틸화 그리고 p53과 Ki-ras 유전자 돌연변이 사이의 상호 관련성", Korean Journal of Health Promotion, 5(1), pp.45~53 (2005), 대한임상건강증진학회
- Sung NY, "Smoking, alcohol and gastric cancer risk in Korean men: the National Health Insurance Corporation Study", Br J Cancer, 97, pp.700~704 (2007)
- En-Joo Jung, "Alcohol Consumption and Mortality in the Korean Multi-center Cancer Cohort Study", 예방의학회지, 45(5), pp.301~308 (2012), 대한예방의학회
- Yi SW, "Alcohol consumption and digestive cancer mortality in Koreans: the Kangwha Cohort Study", J Epidemiol, 20, pp.204~211 (2010)
- Choi YJ, "The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: a nationwide population-based cohort study of South Korea", PLoS One, 12, pp.e0185778~ (2017)
- Sasazuki S, "Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type", Int J Cancer, 101, pp.560~566 (2002)
- Lindblad M, "Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study", Cancer Causes Control, 16, pp.285~294 (2005)
- Larsson SC, "Alcoholic beverage consumption and gastric cancer risk: a prospective population-based study in women", Int J Cancer, 120, pp.373~377 (2007)
- Moy KA, "Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China", Cancer Epidemiol Biomarkers Prev, 19, pp.2287~2297 (2010)
- Minami Y, "Associations of cigarette smoking and alcohol drinking with stomach cancer survival: a prospective patient cohort study in Japan", Int J Cancer, 143, pp.1072~1085 (2018)
- He Z, "Association between alcohol consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies", Oncotarget, 8, pp.84459~84472 (2017)
- Global Status Report on Alcohol and Health 2018, "World Health Organization", World Health Organization, ~ (2018)
- Marshall AW, "Ethanol elimination in males and females: relationship to menstrual cycle and body composition", Hepatology, 3, pp.701~706 (1983)
- Kim YJ, "Alcohol intake and smoking-related processed data sharing from Korean genome and epidemiology study", Public Health Wkly Rep, pp.357~367 (2011)
- Ezzati M, "Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors", pp.959~1109 (2004), World Health Organization
- World Health Organization, "The Asia-Pacific Perspective: Redefining Obesity and Its Treatment" (2000), World Health Organization
- LoConte NK, "Alcohol and cancer: a statement of the American Society of Clinical Oncology", J Clin Oncol, 36, pp.83~93 (2018)
- Lieber CS, "Relationships between nutrition, alcohol use, and liver disease", Alcohol Res Health, 27, pp.220~231 (2003)
- Boffetta P, "Alcohol and cancer", Lancet Oncol, 7, pp.149~156 (2006)
- Blot WJ, "Alcohol and cancer", Cancer Res, 52(Suppl), pp.2119s~2123s (1992)
- Varela-Rey M, "Alcohol, DNA methylation, and cancer", Alcohol Res, 35, pp.25~35 (2013)
- Mason JB, "Folate: effects on carcinogenesis and the potential for cancer chemoprevention", Oncology (Williston Park), 10, pp.1727~1743 (1996)
- Choi SW, "Folate and carcinogenesis: an integrated scheme", J Nutr, 130, pp.129~132 (2000)
- Salaspuro MP, "Alcohol consumption and cancer of the gastrointestinal tract", Best Pract Res Clin Gastroenterol, 17, pp.679~694 (2003)
- Ji BT, "The influence of cigarette smoking, alcohol, and green tea consumption on the risk of carcinoma of the cardia and distal stomach in Shanghai, China", Cancer, 77, pp.2449~2457 (1996)
- Muñoz N, "A case-control study of gastric cancer in Venezuela", Int J Cancer, 93, pp.417~423 (2001)
- Hoshiyama Y, "A case-control study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption in Saitama Prefecture, Japan", Cancer Causes Control, 3, pp.441~448 (1992)
- Gajalakshmi CK, "Lifestyle and risk of stomach cancer: a hospital-based case-control study", Int J Epidemiol, 25, pp.1146~1153 (1996)
- Ma SH, "Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status", Br J Cancer, 113, pp.1381~1388 (2015)
- Everatt R, "Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up", BMC Cancer, 12, pp.475~ (2012)
- Duell EJ, "Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort", Am J Clin Nutr, 94, pp.1266~1275 (2011)
- Ma K, "Alcohol consumption and gastric cancer risk: a meta-analysis", Med Sci Monit, 23, pp.238~246 (2017)
- Lagergren J, "The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia", Int J Cancer, 85, pp.340~346 (2000)
- Frezza M, "High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism", N Engl J Med, 322, pp.95~99 (1990)
- Korean Alcohol Research Foundation, "Drinking Patterns and Alcohol Problems", ~ (2010)
- Liu S, "Reliability of alcohol intake as recalled from 10 years in the past", Am J Epidemiol, 143, pp.177~186 (1996)
- Korea Health Statistics 2017: Korea National Health and Nutrition Examination Survey (KNHANES VII-2), "Korea Centers for Disease Control and Prevention", Korea Ministry of Health and Welfare, ~ (2019)
- Schlesselman JJ, "Case-Control Studies: Design, Conduct, Analysis" (1982), Oxford University Press