본문 바로가기
KERD
논문KCI 등재

177Lu-EDTMP radiation absorbed dose evaluation in man based on biodistribution data in Wistar rats

Bagheri Reza
한국원자력학회 (Korean Nuclear Society)|2023.01|Nuclear Engineering and Technology|제55권 제1호|pp. 254-260|DOI 10.1016/j.net.2022.08.027

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

Absorbed dose177Lu-EDTMPBone metastasesMIRD methodWistar rat
주제분류원자력공학

초록

Skeletal metastases are common in patients suffering from various primary cancers. Radiopharmaceuticals are an effective option for bone pain palliation. In this work, the radiation absorbed dose of 177Lu- EDTMP radiopharmaceutical was estimated for adult man based on biodistribution data in Wistar rats. The MIRD dose calculation method and the Sparks and Aydogan methodology were applied. The results shows that about 46% of injected activity is cumulated on the surface of the trabecular and cortical bones. Radiation absorbed doses of red bone marrow and osteogenic cells were estimated to about 1.1 and 6.2 mGy/MBq, respectively. The maximum administrated activity was obtained 27 MBq/kg of body weight with an effective dose of 0.23 mSv/MBq. The results were compared with other available data from literature. This study indicated that 177Lu-EDTMP provides therapeutic efficacy for achieving bone pain palliation with low undesired dose to other normal organs.

Abstract

Skeletal metastases are common in patients suffering from various primary cancers. Radiopharmaceuticals are an effective option for bone pain palliation. In this work, the radiation absorbed dose of 177Lu- EDTMP radiopharmaceutical was estimated for adult man based on biodistribution data in Wistar rats. The MIRD dose calculation method and the Sparks and Aydogan methodology were applied. The results shows that about 46% of injected activity is cumulated on the surface of the trabecular and cortical bones. Radiation absorbed doses of red bone marrow and osteogenic cells were estimated to about 1.1 and 6.2 mGy/MBq, respectively. The maximum administrated activity was obtained 27 MBq/kg of body weight with an effective dose of 0.23 mSv/MBq. The results were compared with other available data from literature. This study indicated that 177Lu-EDTMP provides therapeutic efficacy for achieving bone pain palliation with low undesired dose to other normal organs.

참고문헌 (50)

  1. A. Bahrami-Samani, "Production, quality control and pharmacokinetic studies of 166Ho-EDTMP for therapeutic applications", Sci. Pharm, 78, pp.423~433 (2010)
  2. S. Dalvand, "Bone marrow dosimetry for 141Ce-EDTMP as a potential bone pain palliation complex : a Monte Carlo study", Appl. Radiat. Isot, 182, pp.110113~ (2022)
  3. Ga-phytate kit and Monte Carlo dosimetry : an effort toward developing an impressive lymphoscintigraphy tracer, "J. Radioanal. Nucl. Chem", 2022, 691~700
  4. R. Bagheri, "Production of Holmium-166 DOTMP : a promising agent for bone marrow ablation in hematologic malignancies", Iran J. Nucl. Med, 19, pp.12~20 (2011)
  5. S. A. Sahafi-Pour, "Internal dosimetry studies of 177Lu-BBN-GABA-DOTA, as a cancer therapy agent, in human tissues based on animal data", Appl. Radiat. Isot, 186, pp.110273~ (2022)
  6. F. Johari Daha, "Production of 177Lu and formulation of Ethylene diamine tetramethylene phosphonate (EDTMP) kits as a bone-seeking radiopharmaceutical", Iran, J. Radiat. Res, 7, pp.229~234 (2010)
  7. M. Tomblyn, "The role of bone-seeking radionuclides in the palliative treatment of patients with painful osteoblastic skeletal metastases", Cancer Control, 19, pp.137~144 (2012)
  8. S. P. Shirmardi, "Internal dosimetry studies of 170Tm-EDTMP complex, as a bone pain palliation agent, in human tissues based on animal data", Appl. Radiat. Isot, 166, pp.109396~ (2020)
  9. Therapeutic Applications of Radiopharmaceuticals, "IAEA", IAEA, ~, pp.TECDOC-1228 (2001)
  10. R. Bagheri, "Dosimetric study of radium-223 chloride and 153Sm-EDTMP for treatment of bone metastases using MCNPX code and available experimental data", J. Radioanal. Nucl. Chem, 303, pp.1991~1998 (2015)
  11. S. Nilsson, "First clinical experience with aemitting radium-223 in the treatment of skeletal metastases", Clin. Cancer Res, 11, pp.4451~4459 (2005)
  12. T. Das, "177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliation", Appl. Radiat. Isot, 57, pp.177~184 (2002)
  13. S. Chakraborty, "177Lu labelled polyaminophosphonates as potential agents for bone pain palliation", Nucl. Med. Commun, 23, pp.67~74 (2002)
  14. I. A. Abbasi, "Preliminary studies on 177Lu-labeled sodium pyrophosphate (177Lu-PYP) as a potential bone-seeking radiopharmaceutical for bone pain palliation", Nucl. Med. Biol, 39, pp.763~769 (2012)
  15. I. A. Abbasi, "Studies on 177Lu-labeled methylene diphosphonate as potential bone-seeking radiopharmaceutical for bone pain palliation", Nucl. Med. Biol, 38, pp.417~425 (2011)
  16. Lu-DOTA-ZOL bone pain palliation in patients with skeletal metastases from various cancers : efficacy and safety results, "EJNMMI Res", 2020, 1~13
  17. S. Chakraborty, "Comparative studies of 177LueEDTMP and 177LueDOTMP as potential agents for palliative radiotherapy of bone metastasis", Appl. Radiat. Isot, 66, pp.1196~1205 (2008)
  18. T. Das, "177Lu-DOTMP : a viable agent for palliative radiotherapy of painful bone metastasis", Radiochim. Acta, 96, pp.55~61 (2008)
  19. N. Bollampally, "Efficacy and safety of 177Lu-DOTMP in palliative treatment of symptomatic skeletal metastases : a prospective study", Nucl. Med. Commun, 42, pp.964~971 (2021)
  20. A. Bahrami-Samani, "Production, quality control and pharmacokinetic studies of 177Lu-EDTMP for human bone pain palliation therapy trials, Iran", J. Pharm. Sci, 11, pp.137~144 (2012)
  21. J. Yuan, "Efficacy and safety of 177Lu-EDTMP in bone metastatic pain palliation in breast cancer and hormone refractory prostate cancer", Clin. Nucl. Med, 38, pp.88~92 (2013)
  22. A. S. Shinto, "177Lu-EDTMP for treatment of bone pain in patients with disseminated skeletal metastases", J. Nucl. Med. Technol, 42, pp.55~61 (2014)
  23. M. Alavi, "Metastatic bone pain palliation using 177Lu-Ethylenediaminetetramethylene phosphonic acid", World J. Nucl. Med, 14, pp.109~115 (2015)
  24. K. K. Agarwal, "177Lu-EDTMP for palliation of pain from bone metastases in patients with prostate and breast cancer : a phase II study", Eur. J. Nucl. Med. Mol. Imaging, 42, pp.79~88 (2015)
  25. C. Bal, "dosimetry and toxicity study of 177Lu-EDTMP in patients : phase 0", I study, 2016, pp.9, 71~84
  26. H. Balter, "177Lu-labeled agents for neuroendocrine tumor therapy and bone pain palliation in Uruguay", Curr. Radiopharm, 9, pp.85~93 (2016)
  27. S. Sharma, "Comparative therapeutic efficacy of 153Sm-EDTMP and 177Lu-EDTMP for bone pain palliation in patients with skeletal metastases : patients' pain score analysis and personalized dosimetry", Front. Med, 4, pp.1~9 (2017)
  28. T. Das, "Theranostic applications of lutetium-177 in radionuclide therapy", Curr. Radiopharm, 9, pp.94~101 (2016)
  29. M. Mirković, "Investigation of 177Lu-labeled HEDP, DPD, and IDP as potential bone pain palliation agents", J. Radiat. Res. Appl. Sci, 13, pp.27~36 (2020)
  30. J. Zaknun, "Pharmacokinetics and dosimetry of the boneseeking agent 177Lu-EDTMP in patients with metastatic prostate cancer", J. Nucl. Med, 52(suppl1), pp.1748~ (2011)
  31. S. Chakraborty, "177Lu-EDTMP: a viable bone pain palliative in skeletal metastasis", Cancer Biother. Radiopharm, 23, pp.202~213 (2008)
  32. M. J. B"elanger, "Biodistribution and radiation dosimetry of 18F-PEB in nonhuman primates", Nucl. Med. Commun, 29, pp.915~919 (2008)
  33. W. K. A. Louw, "Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model", Nucl. Med. Biol, 23, pp.935~940 (1996)
  34. W. E. Bolch, "MIRD pamphlet No. 21: a generalized schema for radiopharmaceutical dosimetrydstandardization of nomenclature", J. Nucl. Med, 50, pp.477~484 (2009)
  35. J. A. Siegel, "Establishing a clinically meaningful predictive model of hematologic toxicity in nonmyeloablative targeted radiotherapy: practical aspects and limitations of red marrow dosimetry", Cancer Biother. Radiopharm, 20, pp.126~140 (2005)
  36. R.B. Sparks, "Comparison of the effectiveness of some common animal data scaling techniques in estimating human radiation dose", Proceedings of the Sixth International Radiopharmaceutical Dosimetry Symposium, pp.705~716 (1996), Oak Ridge Associated Universities
  37. ICRP, "Report of the Task Group on Reference Man" (1975), Pergamon Press
  38. J. M. Peters, "Organ weights and water levels of the rat following reduced food intake", J. Nutr, 90, pp.354~360 (1966)
  39. G. Miller, "Americium systemic biokinetic model for rats", Radiat. Res, 192, pp.75~91 (2019)
  40. M. G. Stabin, "OLINDA", EXM : the Second-generation personal computer software for internal dose assessment in nuclear medicine, 2005, pp.46, 1023~1027
  41. ICRP, "the 2007 Recommendations of the International Commission on Radiological Protection, ume 37" (2007), Elsevier
  42. R. Bagheri, "Study of bone surface absorbed dose in treatment of bone metastases via selected radiopharmaceuticals : using MCNP4C code and available experimental data", Cancer Biother. Radiopharm, 30, pp.174~181 (2015)
  43. R. Bagheri, "Estimation of radiation absorbed dose in man from 166Ho-EDTMP based on biodistribution data in Wistar rats", Radiat. Phys. Chem, 187, pp.1~6 (2021)
  44. ICRP, "Basic Anatomical and Physiological Data for Use in Radiological Protection: Reference Values" (2002), Pergamon Press
  45. M. L. Barlett, "Dosimetry and toxicity of Quadramet for bone marrow ablation in multiple myeloma and other hematological malignancies", Eur. J. Nucl. Med, 29, pp.1470~1477 (2002)
  46. H. B. Breitz, "166Ho-DOTMP radiation-absorbed dose estimation for skeletal targeted radiotherapy", J. Nucl. Med, 47, pp.534~542 (2006)
  47. F. R€osch, "Radiation doses of yttrium-90 citrate and yttrium-90 EDTMP as determined via analogous yttrium-86 complexes and positron emission tomography", Eur. J. Nucl. Med, 23, pp.958~966 (1996)
  48. Sm-EDTMP pharmacokinetics and estimation of radiation absorbed dose on an individual basis, "Phys. Med", 2011, 144~152
  49. M. Lyra, "Rhenium-186-HEDP dosimetry and multiple bone metastases palliation therapy effects", Radionuclide Ther. Oncol. Curr. Status Future Aspects, 10, pp.51~60 (2003)
  50. K. Liepe, "Dosimetry of 188Re-Hydroxyethylidene diphosphonate in human prostate cancer skeletal metastases", J. Nucl. Med, 44, pp.953~960 (2003)

관련 논문AI추천

Prediction of radiation dose to adult human from radiopharmaceutical manufactured by third generation bisphosphonate labeled with RheniumPourhabib Zahra, Ranjbar Hassan한국원자력학회 · Nuclear Engineering and Technology2023 · 제55권 제2호Radiation dosimetry of 89Zr labeled antibody estimated using the MIRD method and MCNP codeJalilifar Mostafa, Sadeghi Mahdi, Saeedzadeh Elham, Yazdi Saeideh Izadi한국원자력학회 · Nuclear Engineering and Technology2023 · 제55권 제4호177Lu 투여환자에 의한 간병인의 외부피폭선량 예측김정민, 이상경, 정규환(사)한국방사선산업학회 · 방사선산업학회지2020 · 제14권 제2호Simulation and assessment of 99mTc absorbed dose into internal organs from cardiac perfusion scanKhorshidi Abdollah, Salari Saghar, Soltani-Nabipour Jamshid한국원자력학회 · Nuclear Engineering and Technology2023 · 제55권 제1호New skeletal dose coefficients of the ICRP-110 reference phantoms for idealized external fields to photons and neutrons using dose response functions (DRFs)신방호, 염연수, 이수민, 이유미, 최지원, 최현준한국원자력학회 · Nuclear Engineering and Technology2023 · 제55권 제6호Preparation and Bioevaluation of 177Lu-labelled Anti-CD44 for Radioimmunotherapy of Colon Cancer이소영, 정성희, 최선주, 홍영돈(사)한국방사선산업학회 · 방사선산업학회지2015 · 제9권 제4호

이 간행물의 다른 논문 (39건)

The regulatory system for imported-cargo radiation monitoring in Korea and a proposal for its improvement김화평, 송창주, 김희근, 손진호, 김성준, 이은지, 정철기, 최우석, 공태영pp. 1-11Laser decontamination for radioactive contaminated metal surface: A reviewLiao Dasong, Wang Feisen, Cai Chuang, Chen Hui, Ji Fei, Yong Chen, Wang Qianpp. 12-24Modeling cryptographic algorithms validation and developing block ciphers with electronic code book for a control system at nuclear power plants함인혜, 손준영, 탁태우pp. 25-36Measurement of missing video frames in NPP control room monitoring system using Kalman filterGupta Manjari, Chaubey Mrityunjay, Singh Lalit Kumarpp. 37-44Analysis of dismantling process and disposal cost of waste RVCH김윤규, 서태원, 박선규pp. 45-51
원문 보기