177Lu 투여환자에 의한 간병인의 외부피폭선량 예측
External Radiation Dosimetry to a Caregiver Exposed by an Adult Patient Treated with 177Lu
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
177Lu has recently been developed as a radiopharmaceutical, but there is no criterionfor 177Lu in the regulation on radiation protection applied to patients administered radioisotopefor medical purposes. The objective of this study is to estimate the external radiation doses ofcaregivers from patients administered 177Lu, and the length of hospitalization required accordingly. Two factors were considered to allow a more realistic assessment of the external radiation dose. First, radioactive change in the body of patients administered 177Lu was calculated using bio-kineticmodeling, which reflected physical radioactive decay and excretion by metabolism. Second, MCNPcomputational simulations were used to calculate dose rate conversion coefficients, which mean therelationship between the effective dose rate received by caregiver and the radioactivity administeredto patient. The external radiation dose of a caregiver calculated was about 3.5 times less than the U.S. NRC method and did not exceed 5 mSv below 600 mCi (22.3 GBq). Therefore, patients administered177Lu less than 600 mCi (22.3 GBq) are not required to be hospitalized for dose constraints of 5 mSv,but patients needed hospitalization when administered in excess of 290 mCi (10.73 GBq) for doseconstraints of 1 mSv.
Abstract
177Lu has recently been developed as a radiopharmaceutical, but there is no criterionfor 177Lu in the regulation on radiation protection applied to patients administered radioisotopefor medical purposes. The objective of this study is to estimate the external radiation doses ofcaregivers from patients administered 177Lu, and the length of hospitalization required accordingly. Two factors were considered to allow a more realistic assessment of the external radiation dose. First, radioactive change in the body of patients administered 177Lu was calculated using bio-kineticmodeling, which reflected physical radioactive decay and excretion by metabolism. Second, MCNPcomputational simulations were used to calculate dose rate conversion coefficients, which mean therelationship between the effective dose rate received by caregiver and the radioactivity administeredto patient. The external radiation dose of a caregiver calculated was about 3.5 times less than the U.S. NRC method and did not exceed 5 mSv below 600 mCi (22.3 GBq). Therefore, patients administered177Lu less than 600 mCi (22.3 GBq) are not required to be hospitalized for dose constraints of 5 mSv,but patients needed hospitalization when administered in excess of 290 mCi (10.73 GBq) for doseconstraints of 1 mSv.
참고문헌 (17)
- 정규환, "갑상선 절제 후 방사성옥소 치료 환자의 간병인에 대한 외부피폭선량 측정 및 예측", 박사, 원자력공학과, pp.2012
- 정준기, "고창순 핵의학", pp.6~7 (2008), 고려의학
- Health Physics Society, "Specifications for the Bottle Manikin Absorber Phantom", American National Standards, ~ (1995)
- Howe B, "NUREG-1556: Consolidated guidance about materials licenses", U. S. NRC, ~ (2008)
- ICRP, "Limits for intakes of radionuclides by workers. ICRP publication 30 Part 3" (1981), Pergamon Press
- ICRP, "Dose coefficients for intakes of radionuclides by workers" (1994), Pergamon Press
- ICRP, "Basic Anatomical & Physiological Data for use in Radiological Protection - The Skeleton" (1995), Pergamon Press
- ICRP, "Individual monitoring for internal exposure of workers" (1997), Pergamon Press
- ICRP, "Human Alimentary Tract Model for Radiological Protection" (2006), Pergamon Press
- ICRP, "Recommendations of the International Commission on Radiological Protection" (2007), Pergamon Press
- ICRP, "Adult Reference Computational Phantoms" (2009), Pergamon Press
- DOTA-TATE of Neuroendocrine Tumours Refractory to Conventional Therapy, "Eur. J. Nucl. Med. Mol. Imaging", 2014, 223~230
- Shinto AS, "177Lu-EDTMP for Treatment of Bone Pain in Patients with Disseminated Skeletal Metastases", J. Nucl. Med. Technol, 42(1), pp.55~61 (2014)
- Sundiöv A, "Individualised 177Lu-DOTATATE Treatment of Neuroendocrine Tumours based on Kidney Dosimetry", Eur. J. Nucl. Med. Mol. Imaging, 44(9), pp.1480~1489 (2017)
- Thapa P, "Clinical Efficacy and Safety Comparison of 177Lu-EDTMP with 153Sm-EDTMP on an Equidose Basis in Patients with Painful Skeletal Metastases", J. Nucl. Med, 56(10), pp.1513~1519 (2015)
- Thomas E, "Health Physics and Radiological Health", pp.267~ (2012), Lippincott Williams &Wilkins
- U. S. Nuclear Regulatory Commission, "Release of Patients Administered Radioactive Materials, Regulatory Guide 8.39", Government Printing Office, ~ (1997)