Deep vein thrombosis prophylaxis in patients who undergo knee arthroscopy: a systematic review
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Background: Knee arthroscopy is one of the most common procedures performed by orthopaedic surgeons. A potentially life-threatening complication following this procedure is deep vein thrombosis (DVT). DVT prophylaxis can be obtained both mechanically (e.g. compression stockings) and chemically (e.g. aspirin, anticoagulants, and factor Xa inhibitors). Currently, there is no standardized guideline for DVT prophylaxis following knee arthroscopy. The purpose of this systematic review was to summarize how DVT prophylaxis is employed for patients who undergo knee arthroscopy. Methods: PubMed, Embase, and Cochrane Library were searched for studies published after 1998 according to PRISMA guidelines. Studies were included if they evaluated DVT prophylaxis regimens in patients of any age who underwent knee arthroscopy. Studies not written in English, analyzed animals or cadavers, did not directly evaluate patients undergoing knee arthroscopy, or did not study DVT prophylaxis were excluded. Results: The initial search identified 300 studies, 15 of which were included. These 15 studies examined methods of DVT prophylaxis including compression stockings (2 of 18; 11%), aspirin (1 of 18; 6%), factor Xa inhibitors (2 of 18; 11%), low molecular weight heparin (12 of 18; 67%), and neuromuscular electrical stimulation (1 of 18; 6%). Overall, 7 of 15 (47%) studies recommended DVT prophylaxis in all patients, and 3 (20%) studies supported its use for high-risk patients. 5 (33%) studies did not support DVT prophylaxis, citing low incidence of post-operative DVT. Conclusions: Compression stockings, aspirin, factor Xa inhibitors, and low molecular weight heparin (LMWH) were identified as possible options for DVT prophylaxis in patients undergoing knee arthroscopy. For high-risk knee arthroscopy patients, factor Xa inhibitors and LMWH drugs are appropriate for DVT prophylaxis.
Abstract
Background: Knee arthroscopy is one of the most common procedures performed by orthopaedic surgeons. A potentially life-threatening complication following this procedure is deep vein thrombosis (DVT). DVT prophylaxis can be obtained both mechanically (e.g. compression stockings) and chemically (e.g. aspirin, anticoagulants, and factor Xa inhibitors). Currently, there is no standardized guideline for DVT prophylaxis following knee arthroscopy. The purpose of this systematic review was to summarize how DVT prophylaxis is employed for patients who undergo knee arthroscopy. Methods: PubMed, Embase, and Cochrane Library were searched for studies published after 1998 according to PRISMA guidelines. Studies were included if they evaluated DVT prophylaxis regimens in patients of any age who underwent knee arthroscopy. Studies not written in English, analyzed animals or cadavers, did not directly evaluate patients undergoing knee arthroscopy, or did not study DVT prophylaxis were excluded. Results: The initial search identified 300 studies, 15 of which were included. These 15 studies examined methods of DVT prophylaxis including compression stockings (2 of 18; 11%), aspirin (1 of 18; 6%), factor Xa inhibitors (2 of 18; 11%), low molecular weight heparin (12 of 18; 67%), and neuromuscular electrical stimulation (1 of 18; 6%). Overall, 7 of 15 (47%) studies recommended DVT prophylaxis in all patients, and 3 (20%) studies supported its use for high-risk patients. 5 (33%) studies did not support DVT prophylaxis, citing low incidence of post-operative DVT. Conclusions: Compression stockings, aspirin, factor Xa inhibitors, and low molecular weight heparin (LMWH) were identified as possible options for DVT prophylaxis in patients undergoing knee arthroscopy. For high-risk knee arthroscopy patients, factor Xa inhibitors and LMWH drugs are appropriate for DVT prophylaxis.
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