Efficacy evaluation of novel organic iron complexes in laying hens: effects on laying performance, egg quality, egg iron content, and blood biochemical parameters
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Objective: This study was conducted to determine the optimal dose of novel iron amino acid complexes (Fe-Lys-Glu) by measuring laying performance, egg quality, egg iron (Fe) concentrations, and blood biochemical parameters in laying hens. Methods: A total of 1,260 18-week-old healthy Beijing White laying hens were randomly divided into 7 groups with 12 replicates of 15 birds each. After a 2-wk acclimation to the basal diet, hens were fed diets supplemented with 0 (negative control, the analyzed innate iron content was 75.06 mg/kg), 15, 30, 45, 60, and 75 mg Fe/kg as Fe-Lys-Glu or 45 mg Fe/kg from FeSO4 (positive control) for 24 wk. Results: Results showed that compared with the negative and positive control groups, dietary supplementation with 30 to 75 mg Fe/kg from Fe-Lys-Glu significantly (linear and quadratic, p<0.05) increased the laying rate (LR) and average daily egg weight (ADEW); hens administered 45 to 75 mg Fe/kg as Fe-Lys-Glu showed a remarkable (linear, p<0.05) decrease in feed conversion ratio. There were no significant differences among all groups in egg quality. The iron concentrations in egg yolk and serum were elevated by increasing Fe-Lys-Glu levels, and the highest iron content was found in 75 mg Fe/kg group. In addition, hens fed 45 mg Fe/kg from Fe-Lys-Glu had (linear and quadratic, p<0.05) higher yolk Fe contents than that with the same dosage of FeSO4 supplementation. The red blood cell (RBC) count and hemoglobin content (linear and quadratic, p<0.05) increased obviously in the groups fed with 30 to 75 mg Fe/kg as Fe-Lys-Glu in comparison with the control group. Fe-Lys-Glu supplementation also (linear and quadratic, p<0.05) enhanced the activity of copper/zinc-superoxide dismutase (Cu/Zn-SOD) in serum, as a result, the serum malonaldehyde content (linear and quadratic, p<0.05) decreased in hens received 60 to 75 mg Fe/kg as Fe-Lys-Glu. Conclusion: Supplementation Fe-Lys-Glu in laying hens could substitute for FeSO4 and the optimal additive levels of Fe-Lys-Glu are 45 mg Fe/kg in layers diets based on the quadratic regression analysis of LR, ADEW, RBC, and Cu/Zn-SOD.
Abstract
Objective: This study was conducted to determine the optimal dose of novel iron amino acid complexes (Fe-Lys-Glu) by measuring laying performance, egg quality, egg iron (Fe) concentrations, and blood biochemical parameters in laying hens. Methods: A total of 1,260 18-week-old healthy Beijing White laying hens were randomly divided into 7 groups with 12 replicates of 15 birds each. After a 2-wk acclimation to the basal diet, hens were fed diets supplemented with 0 (negative control, the analyzed innate iron content was 75.06 mg/kg), 15, 30, 45, 60, and 75 mg Fe/kg as Fe-Lys-Glu or 45 mg Fe/kg from FeSO4 (positive control) for 24 wk. Results: Results showed that compared with the negative and positive control groups, dietary supplementation with 30 to 75 mg Fe/kg from Fe-Lys-Glu significantly (linear and quadratic, p<0.05) increased the laying rate (LR) and average daily egg weight (ADEW); hens administered 45 to 75 mg Fe/kg as Fe-Lys-Glu showed a remarkable (linear, p<0.05) decrease in feed conversion ratio. There were no significant differences among all groups in egg quality. The iron concentrations in egg yolk and serum were elevated by increasing Fe-Lys-Glu levels, and the highest iron content was found in 75 mg Fe/kg group. In addition, hens fed 45 mg Fe/kg from Fe-Lys-Glu had (linear and quadratic, p<0.05) higher yolk Fe contents than that with the same dosage of FeSO4 supplementation. The red blood cell (RBC) count and hemoglobin content (linear and quadratic, p<0.05) increased obviously in the groups fed with 30 to 75 mg Fe/kg as Fe-Lys-Glu in comparison with the control group. Fe-Lys-Glu supplementation also (linear and quadratic, p<0.05) enhanced the activity of copper/zinc-superoxide dismutase (Cu/Zn-SOD) in serum, as a result, the serum malonaldehyde content (linear and quadratic, p<0.05) decreased in hens received 60 to 75 mg Fe/kg as Fe-Lys-Glu. Conclusion: Supplementation Fe-Lys-Glu in laying hens could substitute for FeSO4 and the optimal additive levels of Fe-Lys-Glu are 45 mg Fe/kg in layers diets based on the quadratic regression analysis of LR, ADEW, RBC, and Cu/Zn-SOD.
참고문헌 (41)
- Abbaspour N, "Review on iron and its importance for human health", J Res Med Sci, 19, pp.164~174 (2014)
- Zhou L, "Alterations in cellular iron metabolism provide more therapeutic opportunities for cancer", Int J Mol Sci, 19, pp.1545~ (2018)[DOI]
- Drygalski AV, "Iron metabolism in man", J Parenter Enteral Nutr, 37, pp.599~606 (2013)[DOI]
- Trivedi R, "Delivery systems for improving iron uptake in anemia", Int J Pharm, 601, pp.120590~ (2021)[DOI]
- Wang J, "Regulation of cellular iron metabolism", Biochem J, 434, pp.365~381 (2011)[DOI]
- Sarlak S, "Effects of replacing inorganic with organic iron on performance, egg quality, serum and egg yolk lipids, antioxidant status, and iron accumulation in eggs of laying hens", Biol Trace Elem Res, 199, pp.1986~1999 (2021)[DOI]
- Baker RD, "Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children(0-3 years of age)", Pediatrics, 126, pp.1040~1050 (2010)[DOI]
- Bai S, "High dietary iron differentially influences the iron distribution in the livers and the spleens of laying hens after salmonella typhimurium infection", Biol Trace Elem Res, 185, pp.497~508 (2018)[DOI]
- Bess F, "Dietary iron effects on broiler breeder performance and egg iron contents", Anim Feed Sci Technol, 178, pp.67~73 (2012)[DOI]
- Ma XY, "Relative bioavailability of iron proteinate for broilers fed a casein-dextrose diet", Poult Sci, 93, pp.556~563 (2014)[DOI]
- Kegley EB, "Iron methionine as a source of iron for the neonatal pig", Nutr Res, 22, pp.1209~1217 (2002)[DOI]
- Sun Q, "Effects of methionine hydroxy analog chelated Cu", Mn, J Poult Sci, pp.2012, 49[DOI]
- Zhang LY, "The chemical characteristics of organic iron sources and their relative bioavailabilities for broilers fed a conventional corn-soybean meal diet", J Anim Sci, 94, pp.2378~2396 (2016)
- Layrisse M, "Iron bioavailability in humans from breakfasts enriched with iron bisglycine chelate, phytates and polyphenols", J Nutr, 130, pp.2195~2199 (2000)[DOI]
- Xie C, "Effect of iron glycine chelate supplementation on egg quality and egg iron enrichment in laying hens", Poult Sci, 98, pp.7101~7109 (2019)[DOI]
- AOAC, "Official methods of analysis of AOAC International" (2010), AOAC International
- Gugała D, "The effect of zinc, iron, calcium, and copper from organic sources in pheasant diet on the performance, hatching, minerals, and fatty acid composition of eggs", Poult Sci, 98, pp.4640~4647 (2019)[DOI]
- Wang Z, "The mixed application of organic and inorganic selenium shows better effects on incubation and progeny parameters", Poult Sci, 100, pp.1132~1141 (2021)[DOI]
- Revy PS, "Effect of zinc supplemented as either an organic or an inorganic source and of microbial phytase on zinc and other minerals utilisation by weanling pigs", Anim Feed Sci Technol, 116, pp.93~112 (2004)[DOI]
- Sun J, "Supplemental dietary iron glycine modifies growth, immune function, and antioxidant enzyme activities in broiler chickens", Livest Sci, 176, pp.129~134 (2015)[DOI]
- Langini S, "Ferric glycinate iron bioavailability for rats. As determined by extrinsic radioisotopic labelling of infant formulas", Nutr Rep Int, 38, pp.729~735 (1988)
- Olivares M, "Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans", J Nutr, 127, pp.1407~1411 (1997)[DOI]
- Xie C, "Effects of iron glycine chelate on laying performance, antioxidant activities, serum biochemical indices, iron concentrations and transferrin mRNA expression in laying hens", J Anim Physiol Anim Nutr(Berl), 103, pp.547~554 (2019)[DOI]
- Creech BL, "Effect of dietary trace mineral concentration and source(inorganic vs. chelated)on performance, mineral status, and fecal mineral excretion in pigs from weaning through finishing", J Anim Sci, 82, pp.2140~2147 (2004)[DOI]
- Feng J, "The effect of iron glycine chelate on tissue mineral levels, fecal mineral concentration, and liver antioxidant enzyme activity in weanling pigs", Anim Feed Sci Technol, 150, pp.106~113 (2009)[DOI]
- Kwiecień M, "Effects of iron-glycine chelate on growth, carcass characteristic, liver mineral concentrations and haematological and biochemical blood parameters in broilers", J Anim Physiol Anim Nutr(Berl), 99, pp.1184~1196 (2015)[DOI]
- Tu YJ, "Effect of different iron from sources on laying performance and egg quality in Roman hens", J Zhejiang Univ Sci B, 30, pp.561~566 (2004)
- Inkee P, "Effects of organic iron supplementation on the performance and iron content in the egg yolk of laying hens", J Poult Sci, 46, pp.198~202 (2009)[DOI]
- Greengard O, "Phosvitin, the iron carrier of egg yolk", Biochim Biophys Acta, 90, pp.406~407 (1964)[DOI]
- Samaraweera H, "Egg yolk phosvitin and functional phosphopeptides--review", J Food Sci, 76, pp.R143~ (2011)[DOI]
- Ghasemi HA, "The effect of feeding rations with different ratios of concentrate to alfalfa hay on blood hematological and biochemical parameters of farmed ostriches(Struthio camelus)", Trop Anim Health Prod, 45, pp.1635~1640 (2013)[DOI]
- Hentze MW, "Two to tango : regulation of Mammalian iron metabolism", Cell, 142, pp.24~38 (2010)[DOI]
- Qingqing Deng, "Effects of dietary iron level on growth performance, hematological status, and intestinal function in growing-finishing pigs", Journal of Animal Science, 99(1) (2021), Oxford University Press (OUP)[DOI]
- Kals J, "Effect of different iron sources on the alleviation of nutritional anaemia in common sole(Solea solea)", Aquaculture, 451, pp.266~270 (2016)[DOI]
- Li Y, "Effect of different sources and levels of iron in the diet of sows on iron status in neonatal pigs", Anim Nutr, 4, pp.197~202 (2018)[DOI]
- Egeli AK, "The effect of peroral administration of amino acid-chelated iron to pregnant sows in preventing sow and piglet anaemia", Acta Vet Scand, 39, pp.77~87 (1998)[DOI]
- Andrews NC, "Disorders of iron metabolism", N Engl J Med, 341, pp.1986~1995 (1999)[DOI]
- Trist BG, "Superoxide dismutase 1 in health and disease : How a frontline antioxidant becomes neurotoxic", Angew Chem Int Ed Engl, 60, pp.9215~9246 (2021)[DOI]
- Kohen R, "Invited review : oxidation of biological systems : oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification", Toxicol Pathol, 30, pp.620~650 (2002)[DOI]
- Ghonimi NAM, "Serum malondialdehyde as a lipid peroxidation marker in multiple sclerosis patients and its relation to disease characteristics", Mult Scler Relat Disord, 51, pp.102941~ (2021)[DOI]
- Ma WQ, "Effects of iron glycine chelate on growth, tissue mineral concentrations, fecal mineral excretion, and liver antioxidant enzyme activities in broilers", Biol Trace Elem Res, 149, pp.204~211 (2012)[DOI]
