본문 바로가기
KERD
논문KCI 등재

Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objective Attention deficit/hyperactivity disorder (ADHD), whose definition, diagnosis and treatment has been the subject of debate in the scientific community for a long time, is the most common neurobehavioral disorder in childhood. There are many studies on the pathophysiology of attention deficit. However, there is no study in the literature based on direct or indirect measurement of cerebral venous circulation in ADHD, and the effect of methylphenidate (MPH) treatment on cerebral venous circulation. Therefore, it was aimed to noninvasively measure superior vena cava (SVC) flow, which is an indirect indicator of cerebral venous flow, by transthoracic echocardiography in patients with ADHD.Methods In the study, 44 healthy children, and 40 ADHD patients who were planned to start on osmotic-release oral system (OROS)- MPH were included. SVC flows were measured in healthy children and before and after drug therapy of ADHD patients.Results SVC flow was found to be higher in ADHD patients compared to healthy children. A significant decrease was found in SVC flow of ADHD patients after OROS-MPH treatment. There was no decrease in SVC flow of patients who did not respond adequately to MPH treatment.Conclusion This first study of SVC flow in children with ADHD showed that ADHD was associated with increased SVC flow and MPH treatment had a reducing effect on this increased SVC flow. We believe that noninvasive, easily measurable, and reproducible SVC flow may be a new focus of interest for future comprehensive studies as a biomarker to support clinical evaluation in the diagnosis and treatment follow-up of ADHD patients.

Abstract

Objective Attention deficit/hyperactivity disorder (ADHD), whose definition, diagnosis and treatment has been the subject of debate in the scientific community for a long time, is the most common neurobehavioral disorder in childhood. There are many studies on the pathophysiology of attention deficit. However, there is no study in the literature based on direct or indirect measurement of cerebral venous circulation in ADHD, and the effect of methylphenidate (MPH) treatment on cerebral venous circulation. Therefore, it was aimed to noninvasively measure superior vena cava (SVC) flow, which is an indirect indicator of cerebral venous flow, by transthoracic echocardiography in patients with ADHD.Methods In the study, 44 healthy children, and 40 ADHD patients who were planned to start on osmotic-release oral system (OROS)- MPH were included. SVC flows were measured in healthy children and before and after drug therapy of ADHD patients.Results SVC flow was found to be higher in ADHD patients compared to healthy children. A significant decrease was found in SVC flow of ADHD patients after OROS-MPH treatment. There was no decrease in SVC flow of patients who did not respond adequately to MPH treatment.Conclusion This first study of SVC flow in children with ADHD showed that ADHD was associated with increased SVC flow and MPH treatment had a reducing effect on this increased SVC flow. We believe that noninvasive, easily measurable, and reproducible SVC flow may be a new focus of interest for future comprehensive studies as a biomarker to support clinical evaluation in the diagnosis and treatment follow-up of ADHD patients.

참고문헌 (46)

  1. Polanczyk G, "The worldwide prevalence of ADHD : a systematic review and metaregression analysis", Am J Psychiatry, 164, pp.942~948 (2007)
  2. Banaschewski T, "Attention-deficit", hyperactivity disorder, 2017, pp.114, 149~159
  3. Grünblatt E, "Association study and a systematic meta-analysis of the VNTR polymorphism in the 3’-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder", J Neural Transm(Vienna), 126, pp.517~529 (2019)
  4. da Silva N Jr, "Attention deficit", hyperactivity disorder : is there a correlation between dopamine transporter density and cerebral blood flow?, 2011, pp.36, 656~660
  5. Madras BK, "The dopamine transporter and attention-deficit", hyperactivity disorder, 2005, pp.57, 1397~1409
  6. Umair HM, "Association between central nervous system stimulants used to treat attention deficit hyperactivity disorder(ADHD)and Raynaud’s phenomenon : a scoping review", Semin Arthritis Rheum, 51, pp.1200~1204 (2021)
  7. Fulop GA, "Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment", Am J Physiol Heart Circ Physiol, 316, pp.H1124~H1140 (2019)
  8. de Waal K, "Superior vena cava flow : role, assessment and controversies in the management of perinatal perfusion", Semin Fetal Neonatal Med, 25, pp.101122~ (2020)
  9. Salim MA, "Contribution of superior vena caval flow to total cardiac output in children. A Doppler echocardiographic study", Circulation, 92, pp.1860~1865 (1995)
  10. Osborn DA, "Low superior vena cava flow and effect of inotropes on neurodevelopment to 3 years in preterm infants", Pediatrics, 120, pp.372~380 (2007)
  11. Hunt RW, "Low superior vena cava flow and neurodevelopment at 3 years in very preterm infants", J Pediatr, 145, pp.588~592 (2004)
  12. Kaufman J, "Schedule for affective disorders and schizophrenia for school-age childrenpresent and lifetime version(K-SADS-PL) : initial reliability and validity data", J Am Acad Child Adolesc Psychiatry, 36, pp.980~988 (1997)
  13. Ünal F, "Reliability and validity of the schedule for affective disorders and schizophrenia for school-age children-present and lifetime version, DSM-5 November 2016-Turkish Adaptation (K-SADSPL-DSM-5-T)", Turk Psikiyatri Derg, 30, pp.42~50 (2019)
  14. Turgay A, "Disruptive behavior disorders : child and adolescent screening and rating scales for children, adolescents, parents and teachers" (1994), Michigan Integrative Therapy Institute Publication
  15. Ercan ES, "Development of a test battery for the assessment of attention deficit hyperactivity disorder", Turk J Child Adolesc Ment Health, 8, pp.132~144 (2001)
  16. Groves AM, "Echocardiographic assessment of blood flow volume in the superior vena cava and descending aorta in the newborn infant", Arch Dis Child Fetal Neonatal Ed, 93, pp.F24~F28 (2008)
  17. Katzman MA, "A review of OROS methylphenidate(Concerta(®))in the treatment of attention-deficit", hyperactivity disorder, 2014, pp.28, 1005~1033
  18. Modi NB, "Single-and multiple-dose pharmacokinetics of an oral once-a-day osmotic controlled-release OROS(methylphenidate HCl)formulation", J Clin Pharmacol, 40, pp.379~388 (2000)
  19. Gualtieri CT, "ADHD: is objective diagnosis possible?", Psychiatry(Edgmont), 2, pp.44~53 (2005)
  20. Saad JF, "Is the theta", beta EEG marker for ADHD inherently flawed?, 2018, pp.22, 815~826
  21. Schulz KP, "Response inhibition in adolescents diagnosed with attention deficit hyperactivity disorder during childhood : an event-related FMRI study", Am J Psychiatry, 161, pp.1650~1657 (2004)
  22. Rubia K, "Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control : a study with functional MRI", Am J Psychiatry, 156, pp.891~896 (1999)
  23. Bennett WF, "Anatomy of the superior vena cava and brachiocephalic veins", Thorac Surg Clin, 21, pp.197~203 (2011)
  24. Egemen E, "Primer on cerebrovascular diseases", pp.32~36 (2017), Academic Press
  25. Xing CY, "Distribution of cardiac output to the brain across the adult lifespan", J Cereb Blood Flow Metab, 37, pp.2848~2856 (2017)
  26. Kluckow M, "Low superior vena cava flow and intraventricular haemorrhage in preterm infants", Arch Dis Child Fetal Neonatal Ed, 82, pp.F188~F194 (2000)
  27. Katircioglu SF, "Comparison of metabolic responses to deep hypothermic total circulatory arrest and retrograde cerebral perfusion in an experimental model", Cardiovasc Surg, 10, pp.608~614 (2002)
  28. Rodriguez RA, "Cerebral effects in superior vena caval cannula obstruction : the role of brain monitoring", Ann Thorac Surg, 64, pp.1820~1822 (1997)
  29. Levy F, "Timing, space and ADHD : the dopamine theory revisited", Aust N Z J Psychiatry, 35, pp.504~511 (2001)
  30. Gustafsson P, "Associations between cerebral blood-flow measured by single photon emission computed tomography(SPECT), electro-encephalogram(EEG), behaviour symptoms, cognition and neurological soft signs in children with attention-deficit hyperactivity disorder(ADHD)", Acta Paediatr, 89, pp.830~835 (2000)
  31. Lee JS, "Regional cerebral blood flow in children with attention deficit hyperactivity disorder : comparison before and after methylphenidate treatment", Hum Brain Mapp, 24, pp.157~164 (2005)
  32. Amen DG, "High-resolution brain SPECT imaging in ADHD", Ann Clin Psychiatry, 9, pp.81~86 (1997)
  33. Spalletta G, "Prefrontal blood flow dysregulation in drug naive ADHD children without structural abnormalities", J Neural Transm(Vienna), 108, pp.1203~1216 (2001)
  34. Kemp AH, "The relationship between mental and physical health : insights from the study of heart rate variability", Int J Psychophysiol, 89, pp.288~296 (2013)
  35. Thayer JF, "Heart rate variability, prefrontal neural function, and cognitive performance : the neurovisceral integration perspective on self-regulation, adaptation, and health", Ann Behav Med, 37, pp.141~153 (2009)
  36. Rukmani MR, "Heart rate variability in children with attention-deficit", hyperactivity disorder : a pilot study, 2016, pp.23, 81~88
  37. Buchhorn R, "Heart rate variability and methylphenidate in children with ADHD", Atten Defic Hyperact Disord, 4, pp.85~91 (2012)
  38. Hennissen L, "Cardiovascular effects of stimulant and non-stimulant medication for children and adolescents with ADHD : a systematic review and meta-analysis of trials of methylphenidate, amphetamines and atomoxetine", CNS Drugs, 31, pp.199~215 (2017)
  39. Arnsten AF, "Stimulants : therapeutic actions in ADHD", Neuropsychopharmacology, 31, pp.2376~2383 (2006)
  40. Ayano G, "Dopamine : receptors, functions, synthesis, pathways, locations and mental disorders : review of literatures", J Ment Disord Treat, 2, pp.1000120~ (2016)
  41. Yang Z, "D5 dopamine receptor regulation of phospholipase D", Am J Physiol Heart Circ Physiol, 288, pp.H55~H61 (2005)
  42. Sibley DR, "Molecular neurobiology of dopaminergic receptors", Int Rev Neurobiol, 35, pp.391~415 (1993)
  43. Chen YI, "Pharmacologic neuroimaging of the ontogeny of dopamine receptor function", Dev Neurosci, 32, pp.125~138 (2010)
  44. Volkow ND, "Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain", J Neurosci, 21, pp.RC121~ (2001)
  45. Schrantee A, "The age-dependent effects of a single-dose methylphenidate challenge on cerebral perfusion in patients with attention-deficit", hyperactivity disorder, 2017, pp.13, 123~129
  46. Lufi D, "Sport-based group therapy program for boys with ADHD or with other behavioral disorders", Child Fam Behav Ther, 33, pp.217~230 (2011)

관련 논문AI추천

Altered Arginine/Nitric Oxide Pathway in Children Diagnosed Attention Deficit Hyperactivity Disorder, and the Effect of 10 Weeks Methylphenidate TreatmentBilal Ustundag, Ebru Doneray, Ipek Percinel Yazici, Kemal Utku Yazici대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2022 · 제20권 제2호Cardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity DisorderHayrullah Alp, Mehmet Akif Akıncı, Necati Uzun대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제1호Determination of Serum Vascular Endothelial Growth Factor Levels in Attention Deficit Hyperactivity Disorder: A Case Control StudyArzu Aral, Dicle Büyüktaşkin, Elvan İşeri, Esra Güney, Hüseyin Tunca, Yasemen Işik Taner, Yasemin Taş Torun대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제4호The Effect of Drug Use, Body Mass Index and Blood Pressure on Oxidative Stress Levels in Children and Adolescents with Attention Deficit and Hyperactivity DisorderAyşe Yeşim Göçmen, Dilşad Yıldız Miniksar, Mahmut Kılıç, Mehmet Akif Cansız, Ökkeş Hakan Miniksar대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제1호Diagnostic Performance of Erythropoietin and Erythropoietin Receptors Levels in Children with Attention Deficit Hyperactivity DisorderAli Erdinc Yalin, Ergul Belge Kurutas, Erkan Oner, Hatice Altun, Meltem Gungor, Nilfer Sahin, Ozlem Bozkus, Serap Yalin, Velid Unsal대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2021 · 제19권 제3호주의력결핍/과잉운동 장애(ADHD) 남자 아동들에서 Methlphenidate 치료 전후에 Tc-99m ECD SPECT로 측정된 국소 뇌혈류 이상과 인지적 특성변화와의 연관관계문재석, 오은영, 윤석남, 이명훈, 조선미, 황이삭대한생물치료정신의학회 · 생물치료정신의학2003 · 제9권 제2호

이 간행물의 다른 논문 (12건)