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Evaluation of Asymmetric Dimethylarginine, Malondialdehyde, and Vitamin Levels of Borderline Personality Disorder Patients With and Without Self-Mutilation

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주제분류정신과학

초록

Objective Believing that oxidative stress may be increased in borderline personality disorder (BPD) patients with self-mutilating behaviors (SMB), we aimed to measure serum asymmetric dimethylarginine (ADMA) and malondialdehyde (MDA) levels in these patients.Methods The study included 60 patients diagnosed with BPD and 30 healthy controls. BPD patients were divided into two groups: 30 female patients with SMB and 30 female patients with no-self-mutilating behavior (NSMB). ADMA, MDA, vitamin A, and vitamin E levels were analyzed. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were conducted with the participants.Results Serum ADMA and MDA levels were higher in SMB and NSMB group compared to control group. Serum vitamin E levels were also lower in the SMB group compared to the control group. Positive correlations were determined between both ADMA and MDA, and between BDI and BAI scores. Also, BAI scores were statistically higher in SMB group compared to NSMB group.Conclusion It was discovered that levels of ADMA and MDA, which reflected oxidative stress, were elevated in patients with BPD who exhibited SMB. Accordingly, future studies should investigate the role of oxidative stress in a more comprehensive way in terms of the different mechanisms underlying and treatments involved in borderline personality disorder.

Abstract

Objective Believing that oxidative stress may be increased in borderline personality disorder (BPD) patients with self-mutilating behaviors (SMB), we aimed to measure serum asymmetric dimethylarginine (ADMA) and malondialdehyde (MDA) levels in these patients.Methods The study included 60 patients diagnosed with BPD and 30 healthy controls. BPD patients were divided into two groups: 30 female patients with SMB and 30 female patients with no-self-mutilating behavior (NSMB). ADMA, MDA, vitamin A, and vitamin E levels were analyzed. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were conducted with the participants.Results Serum ADMA and MDA levels were higher in SMB and NSMB group compared to control group. Serum vitamin E levels were also lower in the SMB group compared to the control group. Positive correlations were determined between both ADMA and MDA, and between BDI and BAI scores. Also, BAI scores were statistically higher in SMB group compared to NSMB group.Conclusion It was discovered that levels of ADMA and MDA, which reflected oxidative stress, were elevated in patients with BPD who exhibited SMB. Accordingly, future studies should investigate the role of oxidative stress in a more comprehensive way in terms of the different mechanisms underlying and treatments involved in borderline personality disorder.

참고문헌 (33)

  1. MacDowella KS, "Inflammatory and antioxidant pathway dysfunction in borderline personality disorder", Psychiatry Res, 284, pp.112782~ (2020)
  2. American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" (2013), American Psychiatric Publishing
  3. Zimmerman M, "Axis I diagnostic comorbidity and borderline personality disorder", Compr Psychiatry, 40, pp.245~252 (1999)
  4. Anderson G, "Pathoetiology and pathophysiology of borderline personality : role of prenatal factors, gut microbiome, mu-and kappa-opioid receptors in amygdala-PFC interactions", Prog Neuropsychopharmacol Biol Psychiatry, 98, pp.109782~ (2020)
  5. Lee RJ, "Narcissistic and borderline personality disorders : relationship with oxidative stress", J Pers Disord, 34, pp.6~24 (2020)
  6. Mopuru R, "Cycloxoygenase-2 inhibitors: a novel treatment option for borderline personality disorder?", Indian J Psychol Med (2023)[DOI]
  7. Saccora LF, "Inflammation, anxiety, and stress in bipolar disorder and borderline personality disorder : a narrative review", Neurosci Biobehav Rev, 127, pp.184~192 (2021)
  8. Sher L, "Gender differences and similarities in aggression, suicidal behaviour, and psychiatric comorbidity in borderline personality disorder", Acta Psychiatr Scand, 139, pp.145~153 (2019)
  9. Minutolo G, "Nitric oxide in patients with schizophrenia : the relationship with the severity of illness and the antipsychotic treatment", Expert Opin Pharmacother, 13, pp.1989~1997 (2012)
  10. Ustundag MF, "Nitric oxide, asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in psychotic exacerbation of schizophrenia and bipolar disorder manic episode", Saudi Med J, 41, pp.38~45 (2020)
  11. Canpolat S, "Relationship of asymmetrical dimethylarginine, nitric oxide, and sustained attention during attack in patients with major depressive disorder", Sci World J, 2014, pp.624395~ (2014)
  12. Aydemir Ö, "Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder : an empirical cross-sectional study", Braz J Psychiatry, 36, pp.293~297 (2014)
  13. Sorias S, "DSM-III-R structured clinical interview Turkish version SCID-II personality disorders form" (1990), Ege University Press
  14. Beck AT, "An inventory for measuring clinical anxiety : psychometric properties", J Consult Clin Psychol, 56, pp.893~897 (1988)
  15. Hisli N, "A Study on the Validity of the Beck Depression Inventory", Turk Psikol Derg, 22, pp.118~126 (1988)
  16. Jorgensen A, "Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics : a case-control study", BMC Psychiatry, 15, pp.67~ (2015)
  17. Alderton WK, "Nitric oxide synthases : structure, function and inhibition", Biochem J, 357, pp.593~615 (2001)
  18. Rujescu D, "NOS-I and-III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits", Am J Med Genet B Neuropsychiatr Genet, 147B, pp.42~48 (2008)
  19. Zhoua QG, "Neuronal nitric oxide synthase and affective disorders", IBRO Rep, 5, pp.116~132 (2018)
  20. Köse SS, "Personality disorders diagnosis, causes, and treatments", Demiroglu Sci Univ Florence Nightingale J Transplant, 5, pp.22~31 (2020)
  21. Reif A, "Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans", Arch Gen Psychiatry, 66, pp.41~50 (2009)
  22. Reif A, "A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity", Psychopharmacology(Berl), 214, pp.239~248 (2011)
  23. Eli R, "A chronopharmacological diagnostic test and treatment for bipolar disorder and depression : nitric oxide release during sleep causes it to become depressogenic in a subset of patients", Med Hypotheses, 66, pp.72~75 (2006)
  24. Kielstein H, "Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine(ADMA)and brain-derived neurotrophic factor(BDNF)in depression and behavioural changes : clinical and preclinical data in chronic kidney disease", Nephrol Dial Transplant, 30, pp.1699~1705 (2015)
  25. Forte ARCC, "Oxidative stress and inflammatory process in borderline personality disorder(BPD) : a narrative review", Braz J Med Biol Res, 56, pp.e12484~ (2023)
  26. Manosso LM, "Vitamin E for the management of major depressive disorder : possible role of the anti-inflammatory and antioxidant systems", Nutr Neurosci, 25, pp.1310~1324 (2020)
  27. Wójcicka G, "The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats", Eur J Pharmacol, 789, pp.187~194 (2016)
  28. Hurşitoğlu O, "Diagnostic performance of increased malondialdehyde level and oxidative stress in patients with schizophrenia", Noro Psikiyatr Ars, 58, pp.184~188 (2021)
  29. Sydow K, "ADMA and oxidative stress", Atheroscler Suppl, 4, pp.41~51 (2003)
  30. Coccaro EF, "Elevated plasma oxidative stress markers in individuals with intermittent explosive disorder and correlation with aggression in humans", Biol Psychiatry, 79, pp.127~135 (2016)
  31. D’Souza B, "Oxidative injury and antıoxidant vitamins E and C in schizophrenia", Indian J Clin Biochem, 18, pp.87~90 (2003)
  32. Kamal NAM, "Oxidative stress biomarkers in bipolar disorder with suicidal behavior : a systematic review", J Pharm Negat Results, 10, pp.6~15 (2019)
  33. Zincir SB, "Role of Asymmetric Dimethylarginine in Psychiatric Disorders", Curr Approaches Psychiatry, 6, pp.355~362 (2014)

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