본문 바로가기
KERD
논문KCI 등재

The Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naïve, First Episode, Non-Smoker Generalized Anxiety Disorder Patients

2

조회

0

다운로드

6

인용

0

참고문헌

키워드

초록

Objective: Generalized anxiety disorder (GAD) is a common anxiety disorder. Although lots of research done to reveal neurobiological basis of GAD, it is still unclear. Diagnosis of GAD depends on subjective complaints of patients, thus the need for a biological marker is constantly emerging. In this study, we aimed to investigate diagnostic value of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in GAD. Methods: We evaluated MDA, SOD, and CAT levels in peripheral blood of 46 patients and 45 controls. MDA was measured with Ohkawa’s methods, SOD was measured with Fridovich method, and CAT was measured with Beutler’s method. Results: MDA was significantly increased in patients than controls, medians 4.05 nmol/mg and 1.71 nmol/mg respectively, p<0.001; SOD and CAT activity was significantly decreased in patients than controls, medians of SOD were 159.07 U/mg and 301.87 U/mg, p<0.001 respectively, medians for CAT were 138.47 U/mg and 160.60 U/mg respectively. We found high correlation between Hamilton Anxiety Rating Scale and SOD, MDA r values were 0.723 and 0.715 respectively, p<0.001 for both. Receiver operator characteristic (ROC) curve analysis showed high diagnostic performance for MDA and SOD, low diagnostic performance for CAT, areas under curve were 1.0, 1.0, and 0.648 respectively. Conclusion: Our results reveal possible diagnostic value of MDA, less likely of SOD but not CAT. Future studies should investigate diagnostic value of oxidants and antioxidantn enzymes in larger samples and include diagnostic value of these parameters.

Abstract

Objective: Generalized anxiety disorder (GAD) is a common anxiety disorder. Although lots of research done to reveal neurobiological basis of GAD, it is still unclear. Diagnosis of GAD depends on subjective complaints of patients, thus the need for a biological marker is constantly emerging. In this study, we aimed to investigate diagnostic value of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in GAD. Methods: We evaluated MDA, SOD, and CAT levels in peripheral blood of 46 patients and 45 controls. MDA was measured with Ohkawa’s methods, SOD was measured with Fridovich method, and CAT was measured with Beutler’s method. Results: MDA was significantly increased in patients than controls, medians 4.05 nmol/mg and 1.71 nmol/mg respectively, p<0.001; SOD and CAT activity was significantly decreased in patients than controls, medians of SOD were 159.07 U/mg and 301.87 U/mg, p<0.001 respectively, medians for CAT were 138.47 U/mg and 160.60 U/mg respectively. We found high correlation between Hamilton Anxiety Rating Scale and SOD, MDA r values were 0.723 and 0.715 respectively, p<0.001 for both. Receiver operator characteristic (ROC) curve analysis showed high diagnostic performance for MDA and SOD, low diagnostic performance for CAT, areas under curve were 1.0, 1.0, and 0.648 respectively. Conclusion: Our results reveal possible diagnostic value of MDA, less likely of SOD but not CAT. Future studies should investigate diagnostic value of oxidants and antioxidantn enzymes in larger samples and include diagnostic value of these parameters.

참고문헌 (35)

  1. Bulut M, "Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder", J Affect Disord, 150, pp.829~833 (2013)[DOI]
  2. Camkurt MA, "Depression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blood", J Psychiatr Res, 79, pp.57~60 (2016)[DOI]
  3. Jin-Sung Park, "Lack of Association between Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphisms and Generalized Social Anxiety Disorder in Korean Population", Clinical Psychopharmacology and Neuroscience, 9(3), pp.129~133 (2011), 대한정신약물학회
  4. Wittchen HU, "Disabilities and quality of life in pure and comorbid generalized anxiety disorder and major depression in a national survey", Int Clin Psychopharmacol, 15, pp.319~328 (2000)[DOI]
  5. Biomarkers Definitions Working Group, "Biomarkers and surrogate endpoints: preferred definitions and conceptual framework", Clin Pharmacol Ther, 69, pp.89~95 (2001)[DOI]
  6. Milawaty Nurjono, "A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia", Clinical Psychopharmacology and Neuroscience, 10(2), pp.61~70 (2012), 대한정신약물학회[DOI]
  7. Suk Ling Ma, "Panel of Genetic Variations as a Potential Non-invasive Biomarker for Early Diagnosis of Alzheimer’s Disease", Clinical Psychopharmacology and Neuroscience, 9(2), pp.54~66 (2011), 대한정신약물학회
  8. Mehmet Akif Camkurt, "Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients", Clinical Psychopharmacology and Neuroscience, 14(3), pp.256~260 (2016), 대한정신약물학회
  9. Md. Mamun Al-Amin, "Effects of Antipsychotics on the Inflammatory Response System of Patients with Schizophrenia in Peripheral Blood Mononuclear Cell Cultures", Clinical Psychopharmacology and Neuroscience, 11(3), pp.144~151 (2013), 대한정신약물학회
  10. Steiger A, "Wake and sleep EEG provide biomarkers in depression", J Psychiatr Res, 44, pp.242~252 (2010)[DOI]
  11. Camkurt MA, "Evaluation of malondialdehyde, superoxide dismutase and catalase activity and their diagnostic value in drug naive, first episode, non-smoker major depression patients and healthy controls", Psychiatry Res, 238, pp.81~85 (2016)[DOI]
  12. Gunes M, "Diagnostic performance of increased prolidase activity in schizophrenia", Neurosci Lett, 613, pp.36~40 (2016)[DOI]
  13. Selek S, "Prolidase activity and its diagnostic performance in bipolar disorder", J Affect Disord, 129, pp.84~86 (2011)[DOI]
  14. Selek S, "Oxidative markers of myeloperoxidase and catalase and their diagnostic performance in bipolar disorder", J Affect Disord, 181, pp.92~95 (2015)[DOI]
  15. de Oliveira MR, "Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: effects of sub acute vitamin A supplementation at therapeutic doses", Neurotoxicology, 28, pp.1191~1199 (2007)[DOI]
  16. Desrumaux C, "Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice", FASEB J, 19, pp.296~297 (2005)[DOI]
  17. Hovatta I, "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice", Nature, 438, pp.662~666 (2005)[DOI]
  18. Lopresti AL, "A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers", Prog Neuropsychopharmacol Biol Psychiatry, 48, pp.102~111 (2014)[DOI]
  19. Grignon S, "Assessment of malondialdehyde levels in schizophrenia: a meta-analysis and some methodological considerations", Prog Neuropsychopharmacol Biol Psychiatry, 31, pp.365~369 (2007)[DOI]
  20. Tezcan E, "Free radicals in patients with post-traumatic stress disorder", Eur Arch Psychiatry Clin Neurosci, 253, pp.89~91 (2003)
  21. Atmaca M, "Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment", Eur Arch Psychiatry Clin Neurosci, 254, pp.231~235 (2004)
  22. Atmaca M, "Antioxidant enzyme and malondialdehyde levels in patients with social phobia", Psychiatry Res, 159, pp.95~100 (2008)[DOI]
  23. Beutler E, "Red cell metabolism: a manual of biochemical methods" (1984), Grune & Stratton
  24. Fridovich I, "Superoxide radical and superoxide dismutases", Acc Chem Res, 5, pp.321~326 (1972)[DOI]
  25. Ohkawa H, "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction", Anal Biochem, 95, pp.351~358 (1979)[DOI]
  26. Kuloglu M, "Antioxidant enzyme and malondialdehyde levels in patients with panic disorder", Neuropsychobiology, 46, pp.186~189 (2002)[DOI]
  27. Kuloglu M, "Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorder", Neuropsychobiology, 46, pp.27~32 (2002)[DOI]
  28. Ng F, "Oxidative stress in psychiatric disorders: evidence base and therapeutic implications", Int J Neuropsychopharmacol, 11, pp.851~876 (2008)
  29. Perry JJ, "The structural biochemistry of the superoxide dismutases", Biochim Biophys Acta, 1804, pp.245~262 (2010)[DOI]
  30. Bilici M, "Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments", J Affect Disord, 64, pp.43~51 (2001)[DOI]
  31. Herken H, "Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment", Arch Med Res, 38, pp.247~252 (2007)[DOI]
  32. Bajpai A, "Oxidative stress and major depression", J Clin Diagn Res, 8, pp.CC04~CC07 (2014)
  33. Alpak G, "High catalase and low thiol levels in adult-ADHD patients", Klinik Psikofarmakoloji Bulteni-Bull Clin Psychopharmacol, 24, pp.128~134 (2014)[DOI]
  34. Taylor R, "Interpretation of the correlation coefficient: a basic review", J Diag Med Sonography, 6, pp.35~39 (1990)[DOI]
  35. Kim JW, "Diagnostic utility of quantitative EEG in un-medicated schizophrenia", Neurosci Lett, 589, pp.126~131 (2015)[DOI]

관련 논문AI추천

Serum Levels of 8-Iso-Prostaglandin F2α and Raftlin in Patients with Generalized Anxiety DisorderErgül Belge Kurutas, Onur Hursitoğlu대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제2호The Relationship between the Number of Manic Episodes and Oxidative Stress Indicators in Bipolar DisorderAbdullah Bolu, Emre Aydemir, Murat Erdem, Özcan Uzun, Selma Bozkurt Zincir, Serkan Zincir, Süleyman Akarsu, Yasemin Gülcan Kurt대한신경정신의학회 · PSYCHIATRY INVESTIGATION2018 · 제15권 제5호The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive DisorderFaruk Kurhan, Hamit Hakan Alp, Mesut Işık, Yavuz Selim Atan대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2022 · 제20권 제2호Evaluation of Asymmetric Dimethylarginine, Malondialdehyde, and Vitamin Levels of Borderline Personality Disorder Patients With and Without Self-MutilationSelda Telo, Sema Baykara대한신경정신의학회 · PSYCHIATRY INVESTIGATION2023 · 제20권 제12호Interleukin-40 and Oxidative Stress in Patients With Generalized Anxiety Disorderİsmail Koyuncu, Öznur Akıl, Sıdıka Baziki Çetin, Ülker Atılan Fedai대한신경정신의학회 · PSYCHIATRY INVESTIGATION2025 · 제22권 제10호Evaluation of Paraoxonase, Arylesterase and Malondialdehyde Levels in Schizophrenia Patients Taking Typical, Atypical and Combined Antipsychotic TreatmentAbdullah Atlı, Aslıhan Okan İbiloğlu, Aytekin Sir, İbrahim Kaplan, Mahmut Bulut, Mehmet Akif Camkurt, Mehmet Cemal Kaya, Mehmet Güneş, Süleyman Demir대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2016 · 제14권 제4호

이 간행물의 다른 논문 (15건)