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소아 미세변화형 신증후군에서 혈청 알부민과 IgG의 상관관계

Correlation Between Serum Albumin Level and IgG Level in Minimal Change Nephrotic Syndrome

이경일|이준성|고대균|곽가영|김동언
대한소아신장학회 (The Korean Society Of Pediatric Nephrology)|2007.04|Childhood Kidney Diseases (Childhood Kidney diseases)|제11권 제1호|pp. 16-23

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참고문헌

주제분류소아과학

초록

목 적 : 저감마글로불린혈증은 모든 신증후군에서 관찰되고 있으나 그 병태생리는 알려져 있지 않다. 미세 변화 신증후군 환아들의 혈청 IgG와 알부민 값 간의 상관관계를 분석하고자 하였다. 방 법 : 신증후군으로 진단된 46명의 환아들(단백뇨 >40 mg/m2/h, 혈청 알부민 값 <2.5 g/dL)의 초발 입원 시의 IgG, 알부민 및 총 콜레스테롤 값을 취하고, 각 지표간의 상관관계를 통계학적으로 분석하였다. 결 과 : 신증후군 환아들의 평균 알부민, IgG 및 총 콜레스테롤 값은 각각 1.7±0.3 g/dL, 368±143 mg/dL,431±78 mg/dL이었다. 혈청 알부민과 총 콜레스테롤 값의 관계에서, 두 지표는 서로 반비례를 보였다(r=0.68, P=0.0001). 한편 알부민과 IgG 값들 간의 관계에서 정비례 관계를 보였다(r=0.37, P=0.01). 결 론 : 신증후군에서 IgG 값은 알부민 값과 연관이 있으며, 소변 내 단백 손실의 정도를 반영한다. 이러한 현상을 밝히기 위한 추가 연구가 필요할 것으로 보인다.

Abstract

Purpose : Hypogammaglobulinemia has been observed in nephrotic syndrome, but its pathophysiology remains unknown. We evaluated the relationship between the serum IgG and albumin levels for children with minimal change nephrotic syndrome(MCNS). Methods : The levels of immunoglobulin G(IgG), albumin and total cholesterol of a total of 46 children with MCNS(proteinuria >40 mg/m2/h, and serum albumin level <2.5 g/dL) were analyzed. Results : The mean values of albumin, IgG and total cholesterol in MCNS children were 1.7±0.3 g/dL, 368±143 mg/dL and 431±78 mg/dL, respectively. There was an inverse correlation between the albumin values and the total cholesterol values(r=0.68, P=0.0001), whereas there was a direct-proportional correlation between albumin values and the IgG values(r=0.4, P=0.01). Conclusion : The IgG level is associated with albumin level, and it may reflect the severity of urinary protein loss in MCNS. Further studies are needed to evaluate this phenomenon.

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