GNB3 유전자다형에 따른 12주간 유산소성 운동이 중년여성의 당내성에 미치는 효과
Effect of 12week aerobic exercise according to GNB3 gene polymorphism on glucose tolerance.
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이지영, 한태경, 박수현, 김대영, 김동현, 이신호, 안의수, 강현식. GNB3 유전자다형에 따른 12주 유산소성 운동이 중년여성의 당내성에 미치는 효과. 운동과학, 제15권 제1호, 77-86, 2006. 본 연구의 목적은 12주간의 유산소성 운동이 당내성 개선에 미치는 효과가 GNB3 유전자 다형에 따라 차이가 있는지를 비교분석하는 것이었다. 본 연구의 참여 피검자는 폐경 전 여성 37명과 폐경 후 여성 14명으로 총 51명으로 하였다. 51명의 피험자를 GNB3 유전자 분석을 통해 CC, CT, 그리고 TT형질로 분류하였다. 12주간의 유산소성 운동은 댄스스포츠를 실시하였으며, 분당 최대산소섭취량의 50～60%에 해당하는 운동 강도에서 1회 60분간 주당 3회 총 12주 동안 실시하였다. GNB3 유전자다형에 따른 비만지표 및 안정 시 혈중 glucose와 insulin 농도의 차이는 없었다. 12주 유산소성 운동에 따른 체중, BMI, 허리둘레, 그리고 glucose AUC의 유의한 개선효과는 관찰되었으나 유전자 형질, 그리고 유전자 형질과 12주 운동 간의 상호작용 효과는 없는 것으로 나타났다. GNB3 유전자다형에 따른 12주 유산소성 운동의 당내성의 개선정도는 통계적으로 유의한 수준은 아니었으나, TT 동형접합자에서 가장 낮은 감소를 보였을 뿐만 아니라 12주 유산소성 운동 후에도 OGTT 120분의 혈중 glucose 농도는 당뇨 위험군에 속해 있는 것으로 나타났다. 이상의 결과를 종합해 볼 때, GNB3 유전자다형에 따른 12주 운동이 비만지표에 미치는 영향은 없는 것으로 보인다. 그러나 당내성 개선에 있어서 유의한 수준의 차이는 아니었지만, GNB3 유전자 다형에 따른 의미 있는 경향이 있는 것으로 사료된다.
Abstract
Lee, J.Y, Han, T.K., Park, S.H., Kim, D.Y., Kim, D.H., Lee, S.H. Ann, E.S., Kang, H.S. Effect of 12week aerobic exercise according to GNB3 gene polymorphism on glucose tolerance. Exercise Science, 15(1), 77-86, 2006. The purpose of the study was to compare effect of 12 week aerobic exercise on glucose tolerance according to GNB3 gene polymorphism. A total of 51 apparently healthy mid-life women were recruited via flyers and local advertisement. 12week aerobic exercise was executed dance sports to 50-60% of VO2max, 60min /day, and 3times/week. Repeated measures analysis of variance showed that resting blood glucose and insulin concentration had not significant difference according to GNB3 gene polymorphism. Weight, BMI, waist circumfe- rence, and glucose AUC after 12week exercise were significantly lower than before 12week excercise, but had not significant difference between GNB3 gene polymorphism. Also, there were not interaction effects between 12 week exercise and GNB3 gene polymorphism. A change on glucose tolerance according to GNB3 gene polymorphism after 12 week excercise had not significant difference, but TT homozygotes had lowest decrease on blood glucose AUC. In addition, blood glucose concentration of OGTT-120min in TT homozygotes was over pre-diabetic border line. The current findings of the study suggest that there is no effects of 12week aerobic exercise according to GNB3 gene polymrphism on obesity indices, but not significant difference, GNB3 gene polymorphism may have meaningful trend on glucose tolerance.
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