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여자 청소년의 대사증후군, 인슐린 저항성, 아디포사이토카인 및 심폐체력의 관련성 비교

The association of metabolic syndrome, insulin resistance, adipocytokines and cardiorespiratory fitness in female adolescents

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이규진, 이경영, 신윤아. 여자 청소년의 대사증후군, 인슐린 저항성, 아디포사이토카인 및 심폐체력의 관련성 비교. 운동과학, 제16권 제3호. 201-212, 2007. 본 연구는 여자 청소년을 대상으로 인슐린 저항성과 대사증후군 위험요인, 아디포사이토카인 및 심폐체력 수준의 상관성을 알아보기 위해 실시되었다. 본 연구 대상자는 36명의 여자 고등학생을 대상으로 실시되었다. 비만 여자 청소년은 정상군에 비하여 수축기 혈압을 제외한 모든 대사증후군 위험요인이 높은 수준을 나타내었으며(p<.05), 심혈관질환의 감소를 나타내는 고밀도지단백질 수준은 유의하게 낮은 것으로 나타났다(p<.05). 비만 여자 청소년은 인슐린, 인슐린 저항성 지표, 비스파틴 수준이 정상군에 비하여 유의하게 높았으며(p<.05), 심폐체력 수준은 유의하게 낮은 것으로 나타났다(p<.001). 인슐린, 인슐린 저항성 지표는 대사증후군 위험요인 및 심폐체력 수준과 유의한 상관관계를 나타내었으며(p<.05), 아디포넥틴은 고밀도지단백 콜레스테롤 및 심폐체력과 유의한 양의 상관관계를 나타내었다(p<.05). 비스파틴은 허리둘레와 유의한 양의 상관관계를 나타내었다(p<.05). 이상의 결과를 종합해 보면 여자 청소년의 비만은 인슐린 저항성을 포함한 대사증후군 발병의 위험성을 증가시키며, 비만 청소년의 낮은 심폐체력 수준은 대사증후군의 발병에 영향을 줄 수 있을 것으로 생각된다. 따라서 여자 청소년들의 대사증후군 위험요인을 감소시키고, 인슐린 저항성과 아디포사이토카인의 수준을 개선하기 위한 심폐체력 수준의 증가를 위한 전략이 시급히 요구되는 것으로 사료된다.

Abstract

Lee, K.J., Lee, K.Y., Shin, Y.A. The association of metabolic syndrome, insulin resistance, adipocytokines and cardiorespiratory fitness in female adolescents. Exercise Science, 16(3): 201-212, 2007. The purpose of this study was to investigate the association between metabolic syndrome, insulin resistance, adipocytokines, and cardiorespiratory fitness in female adolescents. The subjects who participated in this study were 36 female adolescents. The obese adolescents had higher metabolic syndrome risk factors except SBP(p<.05), and lower HDL-C that indicates a reduced risk of cardiovascular disease (p<.05). The obese adolescents also showed the up-regulation of insulin levels, insulin resistance, and visfatin concentration (p<.05), and lower levels of cardiorespiratory fitness (p<.001). Insulin and the factors of insulin resistance were associated with metabolic syndrome risk markers and cardiorespiratory fitness (p<.05, respectively). Adipoenctin indicated the positive association with HDL-C and cardiorespiratory fitness (p<.05, respectively). In conclusion, obesity in the female adolescents caused insulin resistance and metabolic syndrome. Moreover, lower levels of cardiorespiratory fitness in obese adolescents may affect the metabolic syndrome and the level of adipocytokines. Therefore, the results of this study suggested that the strategy for improving in the cardiorespiratory fitness is needed to ameliorate the insulin resistance, the metaolbic syndrome risk factors, and the level of adipocytokines.

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