당뇨 전 단계 고령자의 규칙적인 저항성 운동이 뇌신경가소성 인자에 미치는 영향
Effects of Regulatory Resistance Exercise on Brain Neuroplasticity Factors in Prediabetic Elderly
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
PURPOSE: The purpose of this study was to determine whether regulatory resistance exercise is as effective as aerobic training at improving the blood levels of brain-derived neurotrophic factor (BDNF), and nerve growth factors (NGF) as well as Cathepsin B, which are major factors contributing to the regulation of glucose metabolism and neuroplasticity, in prediabetic elderly. METHODS:Among the elderly aged 65 years or older who attended the B welfare center in C city, 16 patients who had no disease and had HbA1c of 5.7-6.4% were randomly assigned into either control group (CO, n=8, age 69.12±2.07 years) and resistance exercise group (RE, n=8, 71.25±1.69 years). Both groups were exercised three times a week for 12 weeks with the exercise intensity of 200- 250 kcal consumed Body composition and basic physical fitness tests were measured at baseline and at week 12. Blood levels of BDNF, NGF and Cathepsin B were also analyzed by using glucose metabolism factor and enzyme immunoassay. RESULTS:As a result, there were no significant differences in all body composition in both CO and RE. In addition, there were no statistically significant differences in all variables of the glycolysis factor. The blood levels of BDNF and NGF were significantly increased after the 12 weeks exercise program in the RE compared with the CO (p<.05). CONCLUSIONS: Based on these results, regular resistance exercise seems to be effective in increasing the brain neuroplasticity factors BDNF and NGF in prediabetic elderly. Depending on the prediabetes stage or the period of stay in the diabetic stage, further study is needed after considering the exercise period and intensity.
Abstract
PURPOSE: The purpose of this study was to determine whether regulatory resistance exercise is as effective as aerobic training at improving the blood levels of brain-derived neurotrophic factor (BDNF), and nerve growth factors (NGF) as well as Cathepsin B, which are major factors contributing to the regulation of glucose metabolism and neuroplasticity, in prediabetic elderly. METHODS:Among the elderly aged 65 years or older who attended the B welfare center in C city, 16 patients who had no disease and had HbA1c of 5.7-6.4% were randomly assigned into either control group (CO, n=8, age 69.12±2.07 years) and resistance exercise group (RE, n=8, 71.25±1.69 years). Both groups were exercised three times a week for 12 weeks with the exercise intensity of 200- 250 kcal consumed Body composition and basic physical fitness tests were measured at baseline and at week 12. Blood levels of BDNF, NGF and Cathepsin B were also analyzed by using glucose metabolism factor and enzyme immunoassay. RESULTS:As a result, there were no significant differences in all body composition in both CO and RE. In addition, there were no statistically significant differences in all variables of the glycolysis factor. The blood levels of BDNF and NGF were significantly increased after the 12 weeks exercise program in the RE compared with the CO (p<.05). CONCLUSIONS: Based on these results, regular resistance exercise seems to be effective in increasing the brain neuroplasticity factors BDNF and NGF in prediabetic elderly. Depending on the prediabetes stage or the period of stay in the diabetic stage, further study is needed after considering the exercise period and intensity.
참고문헌 (30)
- Levitzky YS, "Impact of impaired fasting glucose on cardiovascular disease : the framingham heart study", Journal of the American College of Cardiology, 51(3), pp.264~270 (2008)
- 전기홍, "당뇨병 전단계 및 고위험군 관리와 과학적 근거", 대한의사협회지, 54(10), pp.1020~1027 (2011), 대한의사협회
- Phillips HS, "BDNF mRNA is decreased in the hippocampus of individuals with alzheimer's disease", Neuron, 7(5), pp.695~702 (1991)
- Moon HY, "Running-induced systemic cathepsin B secretion is associated with memory function", Cell Metabolism, 24(2), pp.332~340 (2016)
- Mizuno M, "Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats", Journal of Neuroscience, 20(18), pp.7116~7121 (2000)
- Forti LN, "Doseand gender-specific effects of resistance training on circulating levels of brain derived neurotrophic factor(BDNF)in community-dwelling older adults", Experimental Gerontology, 70, pp.144~149 (2015)
- Ziegenhorn AA, "Serum neurotrophins—a study on the time course and influencing factors in a large old age sample", Neurobiology of Aging, 28(9), pp.1436~1445 (2007)
- Sun Q, "Diagnostic significance of serum levels of nerve growth factor and brain derived neurotrophic factor in diabetic peripheral neuropathy", Medical science monitor : International Medical Journal of Experimental and Clinical Research, 24, pp.5943~ (2018)
- 김유미, "수영운동의 중단과 재개 시 뇌의 신경전달물질, 신경성장인자 및 신경세포생성에 미치는 영향", 한국생활환경학회지, 20(2), pp.932~941 (2013), 한국생활환경학회
- Arida RM, "Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy", Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(4), pp.814~822 (2007)
- Pedersen BK, "Physical activity and muscle–brain crosstalk", Nature Reviews Endocrinology, 15(7), pp.383~ (2019)
- Piwowar A, "Urinary activities of cathepsin B, N-acetyl-ss-D-glucosaminidase, and albuminuriain patients with type 2 diabetes mellitus", Medical Science Monitor, 12(5), pp.CR210~CR214 (2006)
- Grzebyk E, "Advanced glycation endproducts and cathepsin cysteine protease in type 2 diabetic patients", Pol Arch Med Wewn, 123(7-8), pp.364~370 (2013)
- Kim S, "Roles of myokines in exercise-induced improvement of neuropsychiatric function", Pflügers Archiv-European Journal of Physiology, 471(3), pp.491~505 (2019)
- Rozanska O, "Brain-derived neurotrophic factor and diabetes", International Journal of Molecular Sciences, 21(3), pp.841~ (2020)
- van Praag H, "Running enhances neurogenesis, learning, and long-term potentiation in mice", Proceedings of the National Academy of Sciences, 96(23), pp.13427~13431 (1999)
- 최현아, "8주간의 유산소운동과 resveratrol 섭취가 제2형 당뇨병 여성 노인의 체력, 인슐린 저항성, 간기능 및 혈압에 미치는 영향", 체육과학연구, 27(3), pp.507~522 (2016), 국민체육진흥공단 한국스포츠정책과학원
- 이중철, "장기간의 운동중재가 노인의 건강체력, 혈압 및 혈당에 미치는 영향", 운동학 학술지, 12(2), pp.55~65 (2010), 대한운동사협회
- Lara-Castro C, "Visceral adipose tissue in women : longitudinal study of the effects of fat gain, time, and race", Obesity Research, 10(9), pp.868~874 (2002)
- Jee YS, "The effects of regular exercise on glucose, lipid profiles level & body composition of elderly women patients with type-Ⅱ diabetes mellitus", The Korean Journal of Physical Education, 40(2), pp.733~747 (2001)
- 김남훈, "지역사회의 포괄적 지지가 경제적으로 어려운 60세 이상 노인 당뇨병환자의 혈당조절에 미치는 영향", Diabetes and Metabolism Journal, 32(5), pp.453~461 (2008), 대한당뇨병학회
- De la Rosa A, "Longterm exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B", Scientific Reports, 9(1), pp.1~11 (2019)
- Boyuk B, "Relationship between levels of brain-derived neurotrophic factor and metabolic parameters in patients with type 2 diabetes mellitus", Journal of Diabetes Research, 2014, pp.978143~ (2014)
- Fujinami A, "Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus : relationship to glucose metabolism and biomarkers of insulin resistance", Clinical Biochemistry, 41(10-11), pp.812~817 (2008)
- Houtz J, "Neurotrophin signaling is required for glucose-induced insulin secretion", Developmental Cell, 39(3), pp.329~345 (2016)
- Bonini M, "Increased nerve growth factor serum levels in top athletes", Clinical Journal of Sport Medicine, 23(3), pp.228~231 (2013)
- Kim YI, "The impact of exercise training on basal BDNF in athletic adolescents", Journal of Physical Therapy Science, 28(11), pp.3066~3069 (2016)
- Cho SY, "Effects of aerobic exercise training and cranial electrotherapy stimulation on the stress-related hormone, the neurotrophic factor, and mood states in obese middle-aged women : a pilot clinical trial", Salud Mental, 39(5), pp.249~256 (2016)
- Araujo TF, "The role of cathepsin B in autophagy during obesity : a systematic review", Life sciences, 209, pp.274~281 (2018)
- Mizunoe Y, "Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes", Scientific Reports, 10(1), pp.1~12 (2020)