본문 바로가기
KERD
논문KCI 등재

규칙적인 수영 훈련이 L-NAME 유발 고혈압 흰쥐의 대동맥 두께 변화와 내피세포내 Nitric Oxide 활성에 미치는 효과

Effect of regular swimming training on thickness of the aortic wall & endothelium-derived nitric oxide activity in L-NAME induced hypertensive rats.

안의수|조형숙
한국운동생리학회|2004.05|운동과학 (Exercise Science)|제13권 제2호|pp. 189-200

0

조회

0

다운로드

1

인용

0

참고문헌

키워드

혈압심박수고혈압HypertensionBlood pressureNitric OxideAortaL-NAME대동맥Herate rate

초록

규칙적인 수영 훈련이 L-NAME 유발 고혈압 흰쥐의 대동맥 두께 변화와 내피세포내 Nitric Oxide 활성에 미치는 효과. 운동과학, 제13권 2호, 189-200, 2004. 이 연구의 목적은 nitric oxide 합성억제로 유도된 고혈압 흰쥐에 항고혈압 효과가 있는 수영 훈련에 의한 대동맥 두께 변화와 내피세포내 nitric oxide 활성을 알아보고자 하였다. 실험집단(n=40)은 통제집단(Con, n=10), 고혈압 통제집단(L-Con, n=10), 고혈압 운동집단(L-Ex, n=10), 운동집단(Ex, n=10)으로 나누었다. 고혈압은 Sprague Dawely 흰쥐에 Nω-nitro-L-argine methyl ester (L-NAME, 50 mg․kg-1day-1)을 복강내 주사하였고, 수영 훈련은 8주 동안 주당 5일, 하루에 30분씩 실시 하였고, 몸무게와 수축기 혈압은 실험기간 동안 주1회 측정하였으며, 8주 후에 희생하여 대동맥 두께 변화와 혈장 nitrite(NO-2) 을 조사 하였다. 본 연구 결과에서 집단별 수축기 혈압은 고혈압 운동집단에서 3주부터 8주 실험 종료 때까지 유의하게 낮았고(p<.001), 운동집단에서도 통제집단 보다 수축기혈압이 유의하게 낮게 나타났다(p<.05). 혈장 nitrite 농도는 고혈압 통제집단이 다른 세 집단에 비해 유의하게 낮았고(p<.001), 반면 운동집단이 통제집단 보다 유의하게 높게 나타났다(p<.05). 집단간 대동맥 내강 면적은 고혈압 통제집단이 고혈압 운동집단과 운동 집단에 비해 유의하게 좁았다(p<.001) 고혈압 운동집단은 통제집단에 비해 유의하게 넓었고(p<.05) 운동 집단에서도 통제집단에 비해 유의하게 넓었다(p<.001). 집단간 대동맥의 두께는 고혈압 통제집단이 다른 세 집단에 비해 유의하게 두껍게 나타났다(p<.001). 고혈압 운동집 단은 유의한 차는 없었지만 통제집단 보다 얇았으며 운동집단은 고혈압 운동집단에 비해 유의하게 얇게 나타났다(p<.05). 결론적으로 규칙적인 수영 훈련은 NO활성을 통한 혈관 확장으로 혈류량을 증가시키고 대동맥 두께변화를 줄임으로써 항 고혈압 및 혈관의 구조적 변형을 막는 효과가 있음을 알 수 있었다.

Abstract

Effect of regular swimming training on thickness of the aortic wall & endothelium-derived nitric oxide activity in L-NAME induced hypertensive rats. Exercise Science, 13(2): 189-200, 2004. The aim of this study was to investigate the antihypertensive effect of swimming training in nitric oxide synthase inhibitor-induced hypertensive rats by assessment of thickness of the aortic wall and plasma level of endothelium-derived nitric oxide activity. Hypertension was induced by injection (I.P) of, Nω-nitro-L-arginine methyl ester (L-NAME, 50 mgkg-1day-1) to male Sprague-Dawley rats. Experimental groups (n=40) were control group (Con: n=10), control+L-NAME group (L-Con: n=10), L-NAME+ swimming group (L-Ex: n=10) and swimming group (Ex n= 10). Animal in swimming groups were subjected to swim- ming training 5times/week with duration of 30 minutes for 8 weeks. Blood pressure were monitored during experi- mental periods. The animals were sacrificed at 8 weeks, and thickness of the aortic wall and plasma level of endothelium-derived nitrite level was measured. The results of this study showed blood pressure decreased signifi- cantly in L-Exe group at 8 weeks(p<.001). Plasma nitrite level was significantly decreased in L-Con group(<.001). nitrite level was significantly increasern Ex than Con group (p<.05). Area of the aortic lumen was Smaller L-Con than L-Ex and Ex group (p<.001). L-Ex was significantly lager than Con groups (p<.05). The thickness of the aortic wall was decreased in three group than L-Con groups(p<.001). According to above, the author concluded that regular swimming have antihypertensive effects by increase of nitric oxide activity and attenuation of the structural alteration of the aortic wall in L-NAME induced hypertensive rats.

참고문헌 (41)

  1. "Captopril prevents NO deficient hypertension and left ventricular hypertrophy without affecting nitric oxide synthase activity in rats", 45, pp.311~316 (1996)
  2. "Adrenorecepor blackade in angiotensin- induced hypertension Effect on rat coronary arteries and myocardium", pp.60~71 (1982)
  3. "Exercise- and hypertension- induces collagen changes are related to left ventricular fun.tion in rat hearts", pp.1~9 (1996), Physiol
  4. "Chronic inhibition of nitric oxide production accelerates neointima form- ation and impairs endothelial function in hypercho-lesterolemic rabbits", palaci, pp.753~59 (1994)
  5. "Oxidation of LDL to a biologically acyive from by derivatives of nitric oxide and nitrite in the absence of superoxide"
  6. "Capillary pressure gradients in cremaster muscle of normotensive and spontaneously hyper- tensive rats", pp.145~155 (1983)
  7. "role in the genesis of vascular disease", 48, pp.489~509 (1997)
  8. "Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit", pp.1168~72 (1992)
  9. "Exercise reverses peripheral insulin resistance in trained L-NAME -hypertensive rats", 34, pp.768~772 (1999), Hypertension
  10. "Endothelial dysfunction and hypertensive vasoconstriction", 40, pp.113~124 (1999), Pharmacol Res
  11. "The antihypertensive effects of exercise training", pp.250~255 (1992)
  12. "Hypertensive structural changes in systemic precapillary resistance vessels how important are they for in vivo haemodynamics?", 13, pp.1546~1559 (1995)
  13. "The pathogenesis of acute coronary syndromes", pp.242 310~250 318 (1992)
  14. "Inhibition of low density lipop- rotein oxidation by nitric oxide protentil role in atherogenesis", pp.170~74 (1993)
  15. "pharmacognsoy and relationship to the action of organic nitrate esters", pp.651~659 (1989)
  16. "Effects of swim training on blood pressure catecholamine and prostandins in sponta- neously hypertensive rats", pp.205~11 (1994)
  17. "Role of NO in modulating neuronal activity in superficial dorsal horn of spinal cord during exercise pressor reflex", 283 (2002)
  18. "Effect of systemic nitric oxide synthase inhibition on poste- xercise hypotension in humans oyner", 89, pp.1830~1836, Appl
  19. "Chronic NG- Nitro-L-Argine Methyl Ester induced Hypertension", 101(4), pp.423~ (2000)
  20. "Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans", 82, pp.760~764 (1997)
  21. "Acute and chronic effects of exercise on barore- flexes in spontaneously hypertensive rats", 30, pp.714~719 (1997)
  22. "Shear stress abnormalities contribute to endothelial dysfunction in hypertension but not type Ⅱ diabetes", 16, pp.619~1625 (1998)
  23. "Effect on NG-nitro-L-argine methyl ester on renal function and blood presure" (1991)
  24. "L-NAME does not affect exercise-induced pulmonary hypertension in Thotoughbred horses", 84(har), pp.1902~1908
  25. "Persistent hypertension following inhibition of nitric oxide formation in the young wistar rat role of renin and vascular hypertrophy", pp.1083~1088 (1993)
  26. "Chronic L-argine administration attenuates cardic hypertropy in SHR", 27, pp.14~ (1996)
  27. "Carotid intima-media thickness as a measure of vascular target oragn damage", 2, pp.71~77 (2000)
  28. "Long-term inhibition of NO synthesis promotes atheroclerosis in the hypercholesterolemic rabbit thoracic aorta", pp.746~52 (1994)
  29. "Chronic nitric oxide inhibition as a model of hypertensive heart muscle disease", 91, pp.248~55 (1996)
  30. "Effects of changing levels of physical activity on blood pressure and hemodynamics in essential hypertension", pp.473~476 (1986)
  31. "Effect of exercise on blood pressure in rats with chronic NOS inhibition", 87, pp.134~140 (2002), Appl
  32. "The discovery of nitric oxide in the vessel wall", pp.396~401 (1993)
  33. "Coordination of cardiac myofibrillar and sarcotubular activities in rats exercised by swimming" (1984)
  34. "Stereology of the myocardium in hypertensive rats Differences in relation to the time of inhibition of nitric oxide synthesis", 433, pp.369~73 (1998), Virchows Arch
  35. "Upregulation of neuronal nitric oxide synthase in skeletal muscle by swim training", 279 (2000), Heart Circ
  36. "Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression", pp.349~353 (1994)
  37. "Role of nitric oxide in modulating the chronic renal and arterial pressure response to angiotensin Ⅱ", 10, pp.226~ (1997)
  38. "Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise", 27, pp.1125~1134 (1995)
  39. "Oxygen uptake of rats at different work intensities", pp.219~222 (1976)
  40. "Role of nitric oxide in the early renal hemodynamic response after unilateral nephrectomy", 276(va) (1999)
  41. "Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats.", 268, pp.2205~2213

관련 논문AI추천

수영운동이 L-NAME 유발 고혈압 흰쥐 폐에서 eNOS 발현에 미치는 영향이진, 김원규, 조형숙국민체육진흥공단 한국스포츠과학원 · 체육과학연구2005 · 제16권 제3호규칙적인 수영 훈련이 L-NANE 유발 고혈압 흰쥐 좌심실의 제Ⅰ형 Collagen 분포와 좌심실 비대에 미치는 영향안의수, 조형숙국민체육진흥공단 한국스포츠과학원 · 체육과학연구2004 · 제15권 제1호규칙적인 수영 운동이 고혈압 흰쥐 심근의 eNOS, iNOS 유전자 발현 및 대동맥 탄성에 미치는 영향조형숙국민체육진흥공단 한국스포츠과학원 · 체육과학연구2005 · 제16권 제2호지구성 운동훈련과 산화질소 합성 효소 활성이 고혈압쥐(SHR)의 혈압, 심박수, 대동맥벽 두께에 미치는 효과전종귀한국운동생리학회 · 운동과학2005 · 제14권 제2호규칙적인 운동이 고혈압유발 흰쥐의 심근에서 Bcl-2발현 및 Apoptosis변화에 미치는 영향이진, 김원규, 조형숙국민체육진흥공단 한국스포츠과학원 · 체육과학연구2006 · 제17권 제1호10주간의 지구성 트레이닝이 자연발생고혈압쥐의 혈압, 심박수 및 대동맥과 장간막 동맥의 혈관이완반응에 미치는 영향민경은, 박희근, 이상기, 이왕록, 임은미, 전병화, 전종귀한국운동생리학회 · 운동과학2007 · 제16권 제4호

이 간행물의 다른 논문 (12건)

수중재활운동이 뇌졸중 편마비환자의 심폐기능 개선에 미치는 영향김종혁, 조영수, 남상남pp. 141-150고령자들의 심혈관계 질환 위험 요소와 운동참여 여부가 심혈관계 위험 요인, 건강도, 운동능력, 성인병 발병률 및 사망률에 미치는 영향김남익pp. 151-166과체중 및 비만 여성에서 운동 후 ST 분절의 상승과 심박수-회복 궤도(Rate-Recovery Loop)의 변화최건식, 고성경pp. 167-176쥐 골격근의 산화효소 활성, PPAR 단백질 및 지질대사 관련 mRNA 발현에 미치는 트레이닝 효과이장규, 박수연, 김창근, 박인숙, 조인호, 이종삼pp. 177-188운동 시 제 1형 당뇨쥐의 골격근 및 간 조직내 Pro- & Macroglycogen 동원의 차이조인호pp. 201-210
원문 보기