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평지와 내리막 달리기 수행이 creatine kinase 활성도와 백혈구 및 혈중 HSP72 발현에 미치는 영향

Effects of level and downhill running on the creatine kinase, leukocytes, and expression of serum heat shock protein 72

노성규|김정규
한국운동생리학회|2007.05|운동과학 (Exercise Science)|제16권 제2호|pp. 115-124

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HSP72백혈구림프구downhill runninglymphocytesleukocytes내리막 달리기creatine kinase 활성도creatine kinase activity

초록

김정규, 노성규 평지와 내리막 달리기 수행이 creatine kinase 활성도와 백혈구 및 혈중 HSP72 발현에 미치는 영향. 운동과학, 제16권 제2호. 115-124, 2007. 본 연구는 80% HRR의 운동 강도에서 단축성 근수축 형태의 평지달리기와 신장성 근수축 형태의 내리막달리기(-12%) 수행이 근손상 지표인 혈중 CK 활성도와 백혈구 및 혈중 HSP72 발현에 미치는 영향을 살펴보았고 연구 결과는 다음과 같다. 1. 두 가지 운동 형태 모두에서 근손상 지표인 CK 활성도는 운동 직후 및 운동 후 1시간, 4시간, 24시간에서 안정 시에 비해 점차적으로 유의하게 증가되었다. 운동 후 4시간, 24시간에서는 운동 형태에 따른 CK 활성도의 유의한 차이가 나타났는데 평지달리기에 비하여 내리막달리기에서 CK 활성도가 유의하게 높게 나타났다. 2. 두 가지 운동 형태 모두에서 백혈구와 림프구 수치는 운동 직후 유의하게 증가되었다. 운동 후 1시간에서 백혈구감소증과 림프구감소증이 나타났으나 이들 모두 4시간에서 다시 증가되었다가 24시간에서는 안정 시와 유사하게 회복되었다. 두 가지 운동 형태에 따른 백혈구와 림프구 수치의 유의한 차이는 나타나지 않았다. 3. 혈중 HSP72 농도는 두 가지 운동 형태 모두에서 안정 시에 비해 운동 직후에 유의하게 증가되었고 이 후 점차 감소되어 24시간에서는 안정 시와 유사하게 낮아졌다. 백혈구, 림프구와 마찬가지로 두 가지 운동 형태에 따른 혈중 HSP72 발현의 유의한 차이는 없었다.

Abstract

Kim, J.K., & Roh, S.K. Effects of level and downhill running on the creatine kinase activity, leukocytes, and expression of serum heat shock protein 72. Exercise Science, 16(2): 115-124, 2007. This study was to investigate the effects of level and downhill running on the creatine kinase(CK) activity, leukocytes, and expression of serum heat shock protein 72(HSP72). Ten healthy male subjects ran on a treadmill (level and -12% downhill, respectively) for 60 minutes at a work load corresponding to 80% of heart rate reserve. Blood was sampled from a forearm vein at rest, immediately postexercise, and 1h, 4h, 24h after exercise. These samples were analyzed for CK activity, counts of leukocytes and lymphocytes, and serum HSP72 contents. There was a significant increase in plasma CK activity after exercise for both running types and downhill running induced more elevation of CK activity at 4h, 24h postexercise compared with level running. There were similar alterations of leukocytosis and lymphocytosis after exercise in level and downhill running. There was a no significant different in postexercise counts of leukocytes and lymphocytes between exercise types. And also, In expression of serum HSP72, there was no significant difference between exercise types. But similar patterns of changes of serum HSP72 expression, leukocytes, and lymphocytes were shown. In conclusion, although downhill running significantly induced muscle damage, there were no significant differences in exercise-induced alteration of leukocytes and lymphocytes, and expression of serum HSP72, as time trial after exercise, between exercise types. These results suggested that exercise-induced serum HSP72 may be influenced by alteration of leukocytes, not by muscle damage.

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