장시간 운동이 성인 남성의 cTnT와 염증지표에 미치는 영향
The effects of prolonged exercise on cTnT and inflammatory markers in young-aged adults.
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본 연구는 일회성 장시간 운동이 성인남성의 혈중지질, cTnT 및 염증지표인자에 미치는 영향과 운동 시간에 따른 cTnT의 변화와 염증지표인자들 간의 상관관계를 규명하는 데 목적이 있다. 연구대상은 성인 남성 8명으로 구성하였으며, 운동 프로그램은 처음 1시간은 목표심박수 42%, 운동 1시간 이후부터 2시간 이전 목표심박수 60%, 2시간이후부터 3이전까지는 목표심박수 80%를 유지하여 일회성 장시간 운동을 실시하였다. 검사항목은 총콜레스테롤, 중성지방, HDL-Cholesterol, LDL-Cholesterol, 심장 손상표지자로 cTnT, 염증지표로 WBC, CRP를 분석하였다. 연구결과 운동시간에 따라 LDL-C, TG, WBC에서 유의한 차이가 나타났으며(p<.05, p<.05, p<.05), TC, cTnT, CRP에서는 유의한 차이가 나타나지 않았다. 운동 전과 운동 1시간 후, 운동 2시간 후, 운동 3시간 후 변화량에 따른 각요인들의 상관관계 분석에서 cTnT는 시간(r=.432), WBC(.431), 심박수(.431)와 정적 상관관계를 나타내었다. 이상의 결과에서 일회성 장시간 운동에 따라 염증지표인 WBC가 유의하게 증가하였고, 심장 손상표지자인 cTnT 농도는 유의한 변화를 나타내지 않았다. 반면에, 목표심박수 80%의 수준에서 3명의 cTnT 농도가 급성심근경색 cut off 수준 가까이 증가하는 것으로 나타나 장시간의 격렬한 운동이 급사의 위험을 유발할 수 있는 가능성을 시사하고 있다.
Abstract
This study aims to investigate exercise-inducing changes in Cardiad Troponin T(cTnT) as cardiac bio-markers, effects on serum lipids and inflammatory markers, and cTnT-influencing factors during one-time prolonged exercise. A sample of experiment consists of eight adult males. For one-time prolonged exercise program, target heart rate was kept with 42% for the first one hour of exercise, 60% after one hour, 80% after two hours. Total cholestrol, which is serum lipid, triglyceride, HDL-cholesterol and LDL-Cholesterol are measured. As inflammatory markers WBC, CRP are measured and the following results are obtained. LDL-C, WBC showed significant increase(p<.05) and TG showed significant decrease(p<.05) in exercising hours. Total-C, CRP showed no significant differences in exercising hours. The concentration of cTnT showed no significant differences in exercising hours but, three adult males showed an increase close to the level of Acute Myocardial Infarction(AMI) cut off, cTnT showed a positive correlation between time(r=.432), WBC(r=.431), and heart rate(r=.431). As a result, this study indicates that one time prolonged exercise can induce an increase in cTnT as cardiac bio-markers among adult males who don't exercise regularly, and it can also result in the risk of sudden death. Such a concentration of cTnT represents a significant correlation with the level of WBC and accordingly, cTnT increases significantly at higher level of WBC.
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